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Trait
Flattened vertebrae
Clinical name: Platyspondyly
A flattened vertebral body shape with reduced distance between the vertebral endplates.
Summary
- Also called
- Flat vertebral bodies, Flattened vertebral bodies
- Body system
- Abnormality of the musculoskeletal system
Flattened vertebraeHP:0000926
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Read the genes linked to Flattened vertebrae, and the rest of your genome, with one test.
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Get my Genome Test121 genes linked to Flattened vertebrae
Changes in these genes cause rare conditions in which Flattened vertebrae is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ARSKarylsulfatase family member K | Always | In 1 condition |
| B3GALT6beta-1,3-galactosyltransferase 6 | Always | In 3 conditions |
| BGNbiglycan | Always | In 1 condition |
| BMP1bone morphogenetic protein 1 | Always | In 1 condition |
| BNIP1BCL2 interacting protein 1 | Always | In 1 condition |
| CANT1calcium activated nucleotidase 1 | Always | In 2 conditions |
| COL11A2collagen type XI alpha 2 chain | Always | In 4 conditions |
| COL2A1collagen type II alpha 1 chain | Always | In 18 conditions |
| CREB3L1cAMP responsive element binding protein 3 like 1 | Always | In 1 condition |
| CSF1Rcolony stimulating factor 1 receptor | Always | In 1 condition |
| DDR2discoidin domain receptor tyrosine kinase 2 | Always | In 1 condition |
| DNA2DNA replication helicase/nuclease 2 | Always | In 1 condition |
| DYMdymeclin | Always | In 3 conditions |
| ERI1exoribonuclease 1 | Always | In 1 condition |
| EXTL3exostosin like glycosyltransferase 3 | Always | In 1 condition |
| FGFR3fibroblast growth factor receptor 3 | Always | In 5 conditions |
| GLB1galactosidase beta 1 | Always | In 4 conditions |
| GNPNAT1glucosamine-phosphate N-acetyltransferase 1 | Always | In 1 condition |
| IFT43intraflagellar transport 43 | Always | In 1 condition |
| LAMA5laminin subunit alpha 5 | Always | In 1 condition |
| LBRlamin B receptor | Always | In 3 conditions |
| LRP5LDL receptor related protein 5 | Always | In 1 condition |
| MIA3MIA SH3 domain ER export factor 3 | Always | In 1 condition |
| MRPS28mitochondrial ribosomal protein S28 | Always | In 1 condition |
| PCYT1Aphosphate cytidylyltransferase 1A, choline | Always | In 2 conditions |
| PLOD1procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 | Always | In 1 condition |
| PLOD3procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 | Always | In 1 condition |
| PRKG2protein kinase cGMP-dependent 2 | Always | In 2 conditions |
| RAB33BRAB33B, member RAS oncogene family | Always | In 1 condition |
| RPL13ribosomal protein L13 | Always | In 1 condition |
| RSPRY1ring finger and SPRY domain containing 1 | Always | In 2 conditions |
| SERPINH1serpin family H member 1 | Always | In 1 condition |
| SLC13A1solute carrier family 13 member 1 | Always | In 1 condition |
| SLC35D1solute carrier family 35 member D1 | Always | In 1 condition |
| TMEM53transmembrane protein 53 | Always | In 1 condition |
| TOMM7translocase of outer mitochondrial membrane 7 | Always | In 1 condition |
| TRAPPC2trafficking protein particle complex subunit 2 | Always | In 2 conditions |
| TRPV4transient receptor potential cation channel subfamily V member 4 | Always | In 6 conditions |
| XYLT2xylosyltransferase 2 | Always | In 2 conditions |
| ACANaggrecan | Very often (80–99%) | In 3 conditions |
Show 81 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| ACP5acid phosphatase 5, tartrate resistant | Very often (80–99%) | In 2 conditions |
| CCN6cellular communication network factor 6 | Very often (80–99%) | In 2 conditions |
| COG4component of oligomeric golgi complex 4 | Very often (80–99%) | In 2 conditions |
| COMPcartilage oligomeric matrix protein | Very often (80–99%) | In 2 conditions |
| GPX4glutathione peroxidase 4 | Very often (80–99%) | In 2 conditions |
| HDAC6histone deacetylase 6 | Very often (80–99%) | In 2 conditions |
| PTH1Rparathyroid hormone 1 receptor | Very often (80–99%) | In 1 condition |
| RMP64ribonuclease MRP subunit p64 | Very often (80–99%) | In 1 condition |
| SLC29A3solute carrier family 29 member 3 | Very often (80–99%) | In 1 condition |
| SMAD4SMAD family member 4 | Very often (80–99%) | In 2 conditions |
| TCIRG1T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 | Very often (80–99%) | In 1 condition |
| TNFRSF11ATNF receptor superfamily member 11a | Very often (80–99%) | In 1 condition |
| TONSLtonsoku like, DNA repair protein | Very often (80–99%) | In 2 conditions |
| TRIP11thyroid hormone receptor interactor 11 | Very often (80–99%) | In 2 conditions |
| ABCC9ATP binding cassette subfamily C member 9 | Often (30–79%) | In 2 conditions |
| ADAMTSL2ADAMTS like 2 | Often (30–79%) | In 1 condition |
| ATP7AATPase copper transporting alpha | Often (30–79%) | In 2 conditions |
| CCN2cellular communication network factor 2 | Often (30–79%) | In 2 conditions |
| DDRGK1DDRGK domain containing 1 | Often (30–79%) | In 2 conditions |
| HSPG2heparan sulfate proteoglycan 2 | Often (30–79%) | In 2 conditions |
| IDH1isocitrate dehydrogenase (NADP(+)) 1 | Often (30–79%) | In 1 condition |
| KCNJ8potassium inwardly rectifying channel subfamily J member 8 | Often (30–79%) | In 1 condition |
| KIF22kinesin family member 22 | Often (30–79%) | In 1 condition |
| RINT1RAD50 interactor 1 | Often (30–79%) | In 1 condition |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Often (30–79%) | In 1 condition |
| SLC39A13solute carrier family 39 member 13 | Often (30–79%) | In 2 conditions |
| SMARCAL1SNF2 related chromatin remodeling annealing helicase 1 | Often (30–79%) | In 2 conditions |
| SPARCsecreted protein acidic and cysteine rich | Often (30–79%) | In 1 condition |
| B3GAT3beta-1,3-glucuronyltransferase 3 | Sometimes (5–29%) | In 1 condition |
| CHST3carbohydrate sulfotransferase 3 | Sometimes (5–29%) | In 1 condition |
| COL10A1collagen type X alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| COL11A1collagen type XI alpha 1 chain | Sometimes (5–29%) | In 2 conditions |
| COL9A1collagen type IX alpha 1 chain | Sometimes (5–29%) | In 2 conditions |
| COL9A2collagen type IX alpha 2 chain | Sometimes (5–29%) | In 1 condition |
| COL9A3collagen type IX alpha 3 chain | Sometimes (5–29%) | In 1 condition |
| FKBP10FKBP prolyl isomerase 10 | Sometimes (5–29%) | In 2 conditions |
| FLNBfilamin B | Sometimes (5–29%) | In 1 condition |
| FN1fibronectin 1 | Sometimes (5–29%) | In 1 condition |
| GORABgolgin, RAB6 interacting | Sometimes (5–29%) | In 2 conditions |
| IFITM5interferon induced transmembrane protein 5 | Sometimes (5–29%) | In 1 condition |
| KDELR2KDEL endoplasmic reticulum protein retention receptor 2 | Sometimes (5–29%) | In 1 condition |
| LOXL3lysyl oxidase like 3 | Sometimes (5–29%) | In 1 condition |
| MAN2B1mannosidase alpha class 2B member 1 | Sometimes (5–29%) | In 1 condition |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Sometimes (5–29%) | In 1 condition |
| OCRLOCRL inositol polyphosphate-5-phosphatase | Sometimes (5–29%) | In 2 conditions |
| PLOD2procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 | Sometimes (5–29%) | In 2 conditions |
| PYCR1pyrroline-5-carboxylate reductase 1 | Sometimes (5–29%) | In 1 condition |
| RNU4ATACRNA, U4atac small nuclear | Sometimes (5–29%) | In 2 conditions |
| SFRP4secreted frizzled related protein 4 | Sometimes (5–29%) | In 2 conditions |
| XYLT1xylosyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| ZFXzinc finger protein X-linked | Sometimes (5–29%) | In 1 condition |
| NEK1NIMA related kinase 1 | Rarely (1–4%) | In 1 condition |
| PMM2phosphomannomutase 2 | Rarely (1–4%) | In 1 condition |
| SGMS2sphingomyelin synthase 2 | Rarely (1–4%) | In 1 condition |
| ADAadenosine deaminase | Not recorded | In 1 condition |
| AGAaspartylglucosaminidase | Not recorded | In 1 condition |
| AIFM1apoptosis inducing factor mitochondria associated 1 | Not recorded | In 1 condition |
| ALPLalkaline phosphatase, biomineralization associated | Not recorded | In 1 condition |
| CFAP410cilia and flagella associated protein 410 | Not recorded | In 1 condition |
| COL1A1collagen type I alpha 1 chain | Not recorded | In 1 condition |
| COL1A2collagen type I alpha 2 chain | Not recorded | In 1 condition |
| EIF2AK3eukaryotic translation initiation factor 2 alpha kinase 3 | Not recorded | In 1 condition |
| EXOC6Bexocyst complex component 6B | Not recorded | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Not recorded | In 1 condition |
| FLNAfilamin A | Not recorded | In 1 condition |
| GALNSgalactosamine (N-acetyl)-6-sulfatase | Not recorded | In 1 condition |
| GUSBglucuronidase beta | Not recorded | In 1 condition |
| LTBP3latent transforming growth factor beta binding protein 3 | Not recorded | In 1 condition |
| MATN3matrilin 3 | Not recorded | In 1 condition |
| MMP13matrix metallopeptidase 13 | Not recorded | In 1 condition |
| NANSN-acetylneuraminate synthase | Not recorded | In 1 condition |
| P3H1prolyl 3-hydroxylase 1 | Not recorded | In 1 condition |
| PAPSS23'-phosphoadenosine 5'-phosphosulfate synthase 2 | Not recorded | In 1 condition |
| PPIBpeptidylprolyl isomerase B | Not recorded | In 1 condition |
| RUNX2RUNX family transcription factor 2 | Not recorded | In 1 condition |
| SEC24DSEC24 homolog D, COPII component | Not recorded | In 1 condition |
| SLC25A24solute carrier family 25 member 24 | Not recorded | In 1 condition |
| SLC26A2solute carrier family 26 member 2 | Not recorded | In 1 condition |
| TAPT1transmembrane anterior posterior transformation 1 | Not recorded | In 1 condition |
| UFSP2UFM1 specific peptidase 2 | Not recorded | In 1 condition |
| WNT1Wnt family member 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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