Trait
Hoarse voice
Hoarseness refers to a change in the pitch or quality of the voice, with the voice sounding weak, very breathy, scratchy, or husky.
Summary
- Also called
- Hoarseness, Husky voice
- Body system
- Abnormality of the voice
Reference genomeGRCh38hg38
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Get my Genome Test104 genes linked to Hoarse voice
Changes in these genes cause rare conditions in which Hoarse voice is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| APOA1apolipoprotein A1 | Always | In 1 condition |
| ASAH1N-acylsphingosine amidohydrolase 1 | Always | In 3 conditions |
| CD40LGCD40 ligand | Always | In 1 condition |
| ECM1extracellular matrix protein 1 | Always | In 2 conditions |
| KRT14keratin 14 | Always | In 2 conditions |
| KRT5keratin 5 | Always | In 2 conditions |
| LTBP3latent transforming growth factor beta binding protein 3 | Always | In 2 conditions |
| NLRP1NLR family pyrin domain containing 1 | Always | In 1 condition |
| POU1F1POU class 1 homeobox 1 | Always | In 1 condition |
| SMSspermine synthase | Always | In 1 condition |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Very often (80–99%) | In 1 condition |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Very often (80–99%) | In 1 condition |
| CLIP2CAP-Gly domain containing linker protein 2 | Very often (80–99%) | In 1 condition |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Very often (80–99%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Very often (80–99%) | In 1 condition |
| ELNelastin | Very often (80–99%) | In 2 conditions |
| EZH2enhancer of zeste 2 polycomb repressive complex 2 subunit | Very often (80–99%) | In 1 condition |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Very often (80–99%) | In 1 condition |
| GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | Very often (80–99%) | In 1 condition |
| GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta | Very often (80–99%) | In 3 conditions |
| GTF2Igeneral transcription factor IIi | Very often (80–99%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Very often (80–99%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Very often (80–99%) | In 1 condition |
| LIMK1LIM domain kinase 1 | Very often (80–99%) | In 1 condition |
| METTL27methyltransferase like 27 | Very often (80–99%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Very often (80–99%) | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Very often (80–99%) | In 1 condition |
| RAI1retinoic acid induced 1 | Very often (80–99%) | In 2 conditions |
| RFC2replication factor C subunit 2 | Very often (80–99%) | In 1 condition |
| STX1Asyntaxin 1A | Very often (80–99%) | In 1 condition |
| SUZ12SUZ12 polycomb repressive complex 2 subunit | Very often (80–99%) | In 1 condition |
| TBL2transducin beta like 2 | Very often (80–99%) | In 1 condition |
| TMEM270transmembrane protein 270 | Very often (80–99%) | In 1 condition |
| VPS37DVPS37D subunit of ESCRT-I | Very often (80–99%) | In 1 condition |
| ACANaggrecan | Often (30–79%) | In 2 conditions |
| AFF2ALF transcription elongation factor 2 | Often (30–79%) | In 2 conditions |
| AIPAHR interacting HSP90 co-chaperone | Often (30–79%) | In 1 condition |
| C1Rcomplement C1r | Often (30–79%) | In 2 conditions |
| C1Scomplement C1s | Often (30–79%) | In 1 condition |
| CDC73cell division cycle 73 | Often (30–79%) | In 1 condition |
Show 64 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| EIF4A3eukaryotic translation initiation factor 4A3 | Often (30–79%) | In 1 condition |
| GDAP1ganglioside induced differentiation associated protein 1 | Often (30–79%) | In 3 conditions |
| GPC4glypican 4 | Often (30–79%) | In 2 conditions |
| GPR101G protein-coupled receptor 101 | Often (30–79%) | In 1 condition |
| IQSEC2IQ motif and Sec7 domain ArfGEF 2 | Often (30–79%) | In 1 condition |
| LAMA3laminin subunit alpha 3 | Often (30–79%) | In 2 conditions |
| LAMB3laminin subunit beta 3 | Often (30–79%) | In 1 condition |
| LAMC2laminin subunit gamma 2 | Often (30–79%) | In 1 condition |
| MATR3matrin 3 | Often (30–79%) | In 2 conditions |
| MLXIPLMLX interacting protein like | Often (30–79%) | In 1 condition |
| MYH14myosin heavy chain 14 | Often (30–79%) | In 2 conditions |
| NKX2-5NK2 homeobox 5 | Often (30–79%) | In 1 condition |
| PAX8paired box 8 | Often (30–79%) | In 1 condition |
| TLK2tousled like kinase 2 | Often (30–79%) | In 1 condition |
| TRHRthyrotropin releasing hormone receptor | Often (30–79%) | In 1 condition |
| TSHBthyroid stimulating hormone subunit beta | Often (30–79%) | In 1 condition |
| ACTA1actin alpha 1, skeletal muscle | Sometimes (5–29%) | In 1 condition |
| ADARadenosine deaminase RNA specific | Sometimes (5–29%) | In 1 condition |
| DDRGK1DDRGK domain containing 1 | Sometimes (5–29%) | In 2 conditions |
| FBN1fibrillin 1 | Sometimes (5–29%) | In 2 conditions |
| GPC3glypican 3 | Sometimes (5–29%) | In 1 condition |
| HACD13-hydroxyacyl-CoA dehydratase 1 | Sometimes (5–29%) | In 1 condition |
| IFIH1interferon induced with helicase C domain 1 | Sometimes (5–29%) | In 1 condition |
| ITGA7integrin subunit alpha 7 | Sometimes (5–29%) | In 1 condition |
| LSM11LSM11, U7 small nuclear RNA associated | Sometimes (5–29%) | In 1 condition |
| MAP3K20mitogen-activated protein kinase kinase kinase 20 | Sometimes (5–29%) | In 1 condition |
| MAPK1mitogen-activated protein kinase 1 | Sometimes (5–29%) | In 1 condition |
| MFN2mitofusin 2 | Sometimes (5–29%) | In 1 condition |
| MID1midline 1 | Sometimes (5–29%) | In 1 condition |
| MYL2myosin light chain 2 | Sometimes (5–29%) | In 1 condition |
| NFE2L2NFE2 like bZIP transcription factor 2 | Sometimes (5–29%) | In 1 condition |
| PPP3CAprotein phosphatase 3 catalytic subunit alpha | Sometimes (5–29%) | In 1 condition |
| RNASEH2Aribonuclease H2 subunit A | Sometimes (5–29%) | In 1 condition |
| RNASEH2Bribonuclease H2 subunit B | Sometimes (5–29%) | In 1 condition |
| RNASEH2Cribonuclease H2 subunit C | Sometimes (5–29%) | In 1 condition |
| RNU7-1RNA, U7 small nuclear 1 | Sometimes (5–29%) | In 1 condition |
| SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Sometimes (5–29%) | In 1 condition |
| SELENONselenoprotein N | Sometimes (5–29%) | In 1 condition |
| SERPING1serpin family G member 1 | Sometimes (5–29%) | In 1 condition |
| SHOC2SHOC2 leucine rich repeat scaffold protein | Sometimes (5–29%) | In 1 condition |
| SPARTspartin | Sometimes (5–29%) | In 1 condition |
| TPM2tropomyosin 2 | Sometimes (5–29%) | In 1 condition |
| TPM3tropomyosin 3 | Sometimes (5–29%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Sometimes (5–29%) | In 1 condition |
| KRT16keratin 16 | Rarely (1–4%) | In 1 condition |
| KRT17keratin 17 | Rarely (1–4%) | In 2 conditions |
| KRT6Akeratin 6A | Rarely (1–4%) | In 1 condition |
| KRT6Bkeratin 6B | Rarely (1–4%) | In 2 conditions |
| SPTBN1spectrin beta, non-erythrocytic 1 | Rarely (1–4%) | In 1 condition |
| AGAaspartylglucosaminidase | Not recorded | In 1 condition |
| ARID1BAT-rich interaction domain 1B | Not recorded | In 1 condition |
| EDAectodysplasin A | Not recorded | In 1 condition |
| FLNAfilamin A | Not recorded | In 1 condition |
| HRASHRas proto-oncogene, GTPase | Not recorded | In 1 condition |
| IDSiduronate 2-sulfatase | Not recorded | In 1 condition |
| LEMD3LEM domain containing 3 | Not recorded | In 1 condition |
| LIFRLIF receptor subunit alpha | Not recorded | In 1 condition |
| SDHAF2succinate dehydrogenase complex assembly factor 2 | Not recorded | In 1 condition |
| SDHCsuccinate dehydrogenase complex subunit C | Not recorded | In 1 condition |
| SDHDsuccinate dehydrogenase complex subunit D | Not recorded | In 1 condition |
| SLC19A2solute carrier family 19 member 2 | Not recorded | In 1 condition |
| SLC26A2solute carrier family 26 member 2 | Not recorded | In 1 condition |
| THRAthyroid hormone receptor alpha | Not recorded | In 1 condition |
| TRPV4transient receptor potential cation channel subfamily V member 4 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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