Trait
Malabsorption
Impaired ability to absorb one or more nutrients from the intestine.
Summary
- Also called
- Intestinal malabsorption
- Body system
- Abnormality of the digestive system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Malabsorption, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test190 genes linked to Malabsorption
Changes in these genes cause rare conditions in which Malabsorption is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CD55CD55 molecule (Cromer blood group) | Always | In 1 condition |
| DSG1desmoglein 1 | Always | In 1 condition |
| HYOU1hypoxia up-regulated 1 | Always | In 1 condition |
| NEUROG3neurogenin 3 | Always | In 2 conditions |
| SPINK5serine peptidase inhibitor Kazal type 5 | Always | In 2 conditions |
| ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif 3 | Very often (80–99%) | In 1 condition |
| ANTXR2ANTXR cell adhesion molecule 2 | Very often (80–99%) | In 1 condition |
| ATMATM serine/threonine kinase | Very often (80–99%) | In 1 condition |
| BMPR1Abone morphogenetic protein receptor type 1A | Very often (80–99%) | In 1 condition |
| BRCA2BRCA2 DNA repair associated | Very often (80–99%) | In 1 condition |
| CCBE1collagen and calcium binding EGF domains 1 | Very often (80–99%) | In 1 condition |
| CD4CD4 molecule | Very often (80–99%) | In 1 condition |
| CEACAM3CEA cell adhesion molecule 3 | Very often (80–99%) | In 1 condition |
| CEACAM6CEA cell adhesion molecule 6 | Very often (80–99%) | In 1 condition |
| CFTRCF transmembrane conductance regulator | Very often (80–99%) | In 1 condition |
| CHEK2checkpoint kinase 2 | Very often (80–99%) | In 1 condition |
| CLCA4chloride channel accessory 4 | Very often (80–99%) | In 1 condition |
| CYBAcytochrome b-245 alpha chain | Very often (80–99%) | In 1 condition |
| CYBBcytochrome b-245 beta chain | Very often (80–99%) | In 1 condition |
| CYBC1cytochrome b-245 chaperone 1 | Very often (80–99%) | In 1 condition |
| DCTN4dynactin subunit 4 | Very often (80–99%) | In 1 condition |
| EDNRAendothelin receptor type A | Very often (80–99%) | In 1 condition |
| EPCAMepithelial cell adhesion molecule | Very often (80–99%) | In 2 conditions |
| FAT4FAT atypical cadherin 4 | Very often (80–99%) | In 1 condition |
| FLNAfilamin A | Very often (80–99%) | In 1 condition |
| GCLCglutamate-cysteine ligase catalytic subunit | Very often (80–99%) | In 1 condition |
| GLAgalactosidase alpha | Very often (80–99%) | In 1 condition |
| GSTM3glutathione S-transferase mu 3 | Very often (80–99%) | In 1 condition |
| HFEhomeostatic iron regulator | Very often (80–99%) | In 1 condition |
| HMOX1heme oxygenase 1 | Very often (80–99%) | In 1 condition |
| HSD3B7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | Very often (80–99%) | In 1 condition |
| IRF4interferon regulatory factor 4 | Very often (80–99%) | In 1 condition |
| KCNN4potassium calcium-activated channel subfamily N member 4 | Very often (80–99%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Very often (80–99%) | In 1 condition |
| MIFmacrophage migration inhibitory factor | Very often (80–99%) | In 1 condition |
| MLH1mutL homolog 1 | Very often (80–99%) | In 1 condition |
| MSH2mutS homolog 2 | Very often (80–99%) | In 1 condition |
| MSH6mutS homolog 6 | Very often (80–99%) | In 1 condition |
| MUTYHmutY DNA glycosylase | Very often (80–99%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Very often (80–99%) | In 2 conditions |
Show 150 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| NCF2neutrophil cytosolic factor 2 | Very often (80–99%) | In 1 condition |
| NCF4neutrophil cytosolic factor 4 | Very often (80–99%) | In 1 condition |
| NPATnuclear protein, coactivator of histone transcription | Very often (80–99%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Very often (80–99%) | In 1 condition |
| PMS1PMS1 homolog 1, mismatch repair system component | Very often (80–99%) | In 1 condition |
| PMS2PMS1 homolog 2, mismatch repair system component | Very often (80–99%) | In 1 condition |
| POLD1DNA polymerase delta 1, catalytic subunit | Very often (80–99%) | In 1 condition |
| POLEDNA polymerase epsilon, catalytic subunit | Very often (80–99%) | In 1 condition |
| RPS20ribosomal protein S20 | Very often (80–99%) | In 1 condition |
| SEMA4Asemaphorin 4A | Very often (80–99%) | In 1 condition |
| SERPINA1serpin family A member 1 | Very often (80–99%) | In 1 condition |
| SLC11A1solute carrier family 11 member 1 | Very often (80–99%) | In 1 condition |
| SLC26A9solute carrier family 26 member 9 | Very often (80–99%) | In 1 condition |
| SLC39A4solute carrier family 39 member 4 | Very often (80–99%) | In 1 condition |
| SLC6A14solute carrier family 6 member 14 | Very often (80–99%) | In 1 condition |
| SLC9A3solute carrier family 9 member A3 | Very often (80–99%) | In 1 condition |
| STX1Asyntaxin 1A | Very often (80–99%) | In 2 conditions |
| TGFB1transforming growth factor beta 1 | Very often (80–99%) | In 1 condition |
| TGFBR2transforming growth factor beta receptor 2 | Very often (80–99%) | In 1 condition |
| UBR1ubiquitin protein ligase E3 component n-recognin 1 | Very often (80–99%) | In 2 conditions |
| ACDACD shelterin complex subunit and telomerase recruitment factor | Often (30–79%) | In 1 condition |
| AK2adenylate kinase 2 | Often (30–79%) | In 1 condition |
| APCAPC regulator of Wnt signaling pathway | Often (30–79%) | In 1 condition |
| ARXaristaless related homeobox | Often (30–79%) | In 1 condition |
| ASXL1ASXL transcriptional regulator 1 | Often (30–79%) | In 1 condition |
| ATP7AATPase copper transporting alpha | Often (30–79%) | In 1 condition |
| CAV1caveolin 1 | Often (30–79%) | In 1 condition |
| CBLCbl proto-oncogene | Often (30–79%) | In 1 condition |
| CCN2cellular communication network factor 2 | Often (30–79%) | In 1 condition |
| CCR6C-C motif chemokine receptor 6 | Often (30–79%) | In 1 condition |
| CDCA7cell division cycle associated 7 | Often (30–79%) | In 1 condition |
| CLTRNcollectrin, amino acid transport regulator | Often (30–79%) | In 1 condition |
| CTC1CST telomere replication complex component 1 | Often (30–79%) | In 1 condition |
| CTNNB1catenin beta 1 | Often (30–79%) | In 1 condition |
| DKC1dyskerin pseudouridine synthase 1 | Often (30–79%) | In 1 condition |
| DMP1dentin matrix acidic phosphoprotein 1 | Often (30–79%) | In 1 condition |
| DNMT3BDNA methyltransferase 3 beta | Often (30–79%) | In 2 conditions |
| ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 | Often (30–79%) | In 1 condition |
| HELLShelicase, lymphoid specific | Often (30–79%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Often (30–79%) | In 1 condition |
| IRF5interferon regulatory factor 5 | Often (30–79%) | In 1 condition |
| NHP2NHP2 ribonucleoprotein | Often (30–79%) | In 1 condition |
| NOP10NOP10 ribonucleoprotein | Often (30–79%) | In 1 condition |
| NPM1nucleophosmin 1 | Often (30–79%) | In 1 condition |
| PARNpoly(A)-specific ribonuclease | Often (30–79%) | In 1 condition |
| PEX1peroxisomal biogenesis factor 1 | Often (30–79%) | In 1 condition |
| PEX10peroxisomal biogenesis factor 10 | Often (30–79%) | In 1 condition |
| PEX11Bperoxisomal biogenesis factor 11 beta | Often (30–79%) | In 1 condition |
| PEX12peroxisomal biogenesis factor 12 | Often (30–79%) | In 1 condition |
| PEX13peroxisomal biogenesis factor 13 | Often (30–79%) | In 1 condition |
| PEX14peroxisomal biogenesis factor 14 | Often (30–79%) | In 1 condition |
| PEX16peroxisomal biogenesis factor 16 | Often (30–79%) | In 1 condition |
| PEX19peroxisomal biogenesis factor 19 | Often (30–79%) | In 1 condition |
| PEX2peroxisomal biogenesis factor 2 | Often (30–79%) | In 1 condition |
| PEX26peroxisomal biogenesis factor 26 | Often (30–79%) | In 1 condition |
| PEX3peroxisomal biogenesis factor 3 | Often (30–79%) | In 1 condition |
| PEX5peroxisomal biogenesis factor 5 | Often (30–79%) | In 1 condition |
| PEX6peroxisomal biogenesis factor 6 | Often (30–79%) | In 1 condition |
| RECQL4RecQ like helicase 4 | Often (30–79%) | In 1 condition |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Often (30–79%) | In 2 conditions |
| RTEL1regulator of telomere elongation helicase 1 | Often (30–79%) | In 1 condition |
| RUNX1RUNX family transcription factor 1 | Often (30–79%) | In 1 condition |
| SAA1serum amyloid A1 | Often (30–79%) | In 1 condition |
| SLC6A19solute carrier family 6 member 19 | Often (30–79%) | In 1 condition |
| SRSF2serine and arginine rich splicing factor 2 | Often (30–79%) | In 1 condition |
| TERCtelomerase RNA component | Often (30–79%) | In 1 condition |
| TERTtelomerase reverse transcriptase | Often (30–79%) | In 1 condition |
| TET2tet methylcytosine dioxygenase 2 | Often (30–79%) | In 1 condition |
| TINF2TERF1 interacting nuclear factor 2 | Often (30–79%) | In 1 condition |
| TRMT5tRNA methyltransferase 5 | Often (30–79%) | In 1 condition |
| TYMSthymidylate synthetase | Often (30–79%) | In 1 condition |
| UHRF1ubiquitin like with PHD and ring finger domains 1 | Often (30–79%) | In 1 condition |
| USB1U6 snRNA biogenesis phosphodiesterase 1 | Often (30–79%) | In 1 condition |
| WRAP53WD repeat containing antisense to TP53 | Often (30–79%) | In 1 condition |
| ZBTB24zinc finger and BTB domain containing 24 | Often (30–79%) | In 1 condition |
| AGAaspartylglucosaminidase | Sometimes (5–29%) | In 1 condition |
| AIREautoimmune regulator | Sometimes (5–29%) | In 2 conditions |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Sometimes (5–29%) | In 1 condition |
| BLNKB cell linker | Sometimes (5–29%) | In 1 condition |
| BTKBruton tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Sometimes (5–29%) | In 1 condition |
| C4Acomplement C4A (Chido/Rodgers blood group) | Sometimes (5–29%) | In 1 condition |
| CALRcalreticulin | Sometimes (5–29%) | In 1 condition |
| CCR1C-C motif chemokine receptor 1 | Sometimes (5–29%) | In 1 condition |
| CD79ACD79a molecule | Sometimes (5–29%) | In 1 condition |
| CD79BCD79b molecule | Sometimes (5–29%) | In 1 condition |
| CISD2CDGSH iron sulfur domain 2 | Sometimes (5–29%) | In 1 condition |
| CLIP2CAP-Gly domain containing linker protein 2 | Sometimes (5–29%) | In 1 condition |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Sometimes (5–29%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Sometimes (5–29%) | In 1 condition |
| ELNelastin | Sometimes (5–29%) | In 1 condition |
| ERAP1endoplasmic reticulum aminopeptidase 1 | Sometimes (5–29%) | In 1 condition |
| F5coagulation factor V | Sometimes (5–29%) | In 1 condition |
| FASFas cell surface death receptor | Sometimes (5–29%) | In 1 condition |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Sometimes (5–29%) | In 1 condition |
| FOXN1forkhead box N1 | Sometimes (5–29%) | In 1 condition |
| FOXP3forkhead box P3 | Sometimes (5–29%) | In 1 condition |
| GTF2Igeneral transcription factor IIi | Sometimes (5–29%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Sometimes (5–29%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Sometimes (5–29%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Sometimes (5–29%) | In 1 condition |
| HPGD15-hydroxyprostaglandin dehydrogenase | Sometimes (5–29%) | In 1 condition |
| IFNGR1interferon gamma receptor 1 | Sometimes (5–29%) | In 1 condition |
| IGHMimmunoglobulin heavy constant mu | Sometimes (5–29%) | In 1 condition |
| IGLL1immunoglobulin lambda like polypeptide 1 | Sometimes (5–29%) | In 1 condition |
| IL10interleukin 10 | Sometimes (5–29%) | In 1 condition |
| IL12Ainterleukin 12A | Sometimes (5–29%) | In 1 condition |
| IL12A-AS1IL12A antisense RNA 1 | Sometimes (5–29%) | In 1 condition |
| IL23Rinterleukin 23 receptor | Sometimes (5–29%) | In 1 condition |
| JAK2Janus kinase 2 | Sometimes (5–29%) | In 1 condition |
| KLRC4killer cell lectin like receptor C4 | Sometimes (5–29%) | In 1 condition |
| LIG4DNA ligase 4 | Sometimes (5–29%) | In 1 condition |
| LIMK1LIM domain kinase 1 | Sometimes (5–29%) | In 1 condition |
| LPIN2lipin 2 | Sometimes (5–29%) | In 1 condition |
| LRRC8Aleucine rich repeat containing 8 VRAC subunit A | Sometimes (5–29%) | In 1 condition |
| MADDMAP kinase activating death domain | Sometimes (5–29%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Sometimes (5–29%) | In 2 conditions |
| METTL27methyltransferase like 27 | Sometimes (5–29%) | In 1 condition |
| MYD88MYD88 innate immune signal transduction adaptor | Sometimes (5–29%) | In 1 condition |
| OCRLOCRL inositol polyphosphate-5-phosphatase | Sometimes (5–29%) | In 1 condition |
| PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | Sometimes (5–29%) | In 2 conditions |
| PIK3R1phosphoinositide-3-kinase regulatory subunit 1 | Sometimes (5–29%) | In 2 conditions |
| RFC2replication factor C subunit 2 | Sometimes (5–29%) | In 1 condition |
| SLC29A3solute carrier family 29 member 3 | Sometimes (5–29%) | In 1 condition |
| SLCO2A1solute carrier organic anion transporter family member 2A1 | Sometimes (5–29%) | In 1 condition |
| SPI1Spi-1 proto-oncogene | Sometimes (5–29%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Sometimes (5–29%) | In 1 condition |
| TBL2transducin beta like 2 | Sometimes (5–29%) | In 1 condition |
| TCF3transcription factor 3 | Sometimes (5–29%) | In 1 condition |
| TLR4toll like receptor 4 | Sometimes (5–29%) | In 1 condition |
| TMEM270transmembrane protein 270 | Sometimes (5–29%) | In 1 condition |
| TREHtrehalase | Sometimes (5–29%) | In 1 condition |
| UBAC2UBA domain containing 2 | Sometimes (5–29%) | In 1 condition |
| VPS37DVPS37D subunit of ESCRT-I | Sometimes (5–29%) | In 1 condition |
| WFS1wolframin ER transmembrane glycoprotein | Sometimes (5–29%) | In 1 condition |
| ABCB11ATP binding cassette subfamily B member 11 | Not recorded | In 1 condition |
| ABCB4ATP binding cassette subfamily B member 4 | Not recorded | In 1 condition |
| ATP8B1ATPase phospholipid transporting 8B1 | Not recorded | In 1 condition |
| CIITAclass II major histocompatibility complex transactivator | Not recorded | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Not recorded | In 1 condition |
| KDM6Alysine demethylase 6A | Not recorded | In 1 condition |
| KMT2Dlysine methyltransferase 2D | Not recorded | In 1 condition |
| PCSK1proprotein convertase subtilisin/kexin type 1 | Not recorded | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Not recorded | In 2 conditions |
| RFX6regulatory factor X6 | Not recorded | In 1 condition |
| SIsucrase-isomaltase | Not recorded | In 1 condition |
| SLC2A2solute carrier family 2 member 2 | Not recorded | In 1 condition |
| SLC46A1solute carrier family 46 member 1 | Not recorded | In 1 condition |
| SLC5A1solute carrier family 5 member 1 | Not recorded | In 1 condition |
| TYMPthymidine phosphorylase | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks