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Trait
Low muscle tone, in neonatal onset
Clinical name: Neonatal hypotonia
Muscular hypotonia (abnormally low muscle tone) manifesting in the neonatal period.
Summary
- Also called
- Hypotonia, in neonatal onset, Hypotonia, neonatal
- Body system
- Abnormality of the musculoskeletal system
Low muscle tone, in neonatal onsetHP:0001319
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Read the genes linked to Low muscle tone, in neonatal onset, and the rest of your genome, with one test.
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Get my Genome Test187 genes linked to Low muscle tone, in neonatal onset
Changes in these genes cause rare conditions in which Low muscle tone, in neonatal onset is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ACOX1acyl-CoA oxidase 1 | Always | In 1 condition |
| AP4B1adaptor related protein complex 4 subunit beta 1 | Always | In 1 condition |
| AP4E1adaptor related protein complex 4 subunit epsilon 1 | Always | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Always | In 1 condition |
| CCDC88Acoiled-coil and HOOK domain protein 88A | Always | In 1 condition |
| COA6cytochrome c oxidase assembly factor 6 | Always | In 1 condition |
| COPB1coat protein complex I subunit beta 1 | Always | In 1 condition |
| DSTdystonin | Always | In 1 condition |
| EEF1A2eukaryotic translation elongation factor 1 alpha 2 | Always | In 1 condition |
| FKBP14FKBP prolyl isomerase 14 | Always | In 1 condition |
| FKRPfukutin related protein | Always | In 3 conditions |
| FKTNfukutin | Always | In 2 conditions |
| FXR1FMR1 autosomal homolog 1 | Always | In 2 conditions |
| GABRA2gamma-aminobutyric acid type A receptor subunit alpha2 | Always | In 1 condition |
| GOT2glutamic-oxaloacetic transaminase 2 | Always | In 1 condition |
| HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2 | Always | In 2 conditions |
| IGHMBP2immunoglobulin mu DNA binding protein 2 | Always | In 1 condition |
| ITPR1inositol 1,4,5-trisphosphate receptor type 1 | Always | In 1 condition |
| JKAMPJNK1/MAPK8 associated membrane protein | Always | In 1 condition |
| LARGE1LARGE xylosyl- and glucuronyltransferase 1 | Always | In 1 condition |
| LRRC7leucine rich repeat containing 7 | Always | In 1 condition |
| MAGmyelin associated glycoprotein | Always | In 1 condition |
| MAGEL2MAGE family member L2 | Always | In 4 conditions |
| MDGA2MAM domain containing glycosylphosphatidylinositol anchor 2 | Always | In 1 condition |
| MKRN3makorin ring finger protein 3 | Always | In 1 condition |
| MRPS16mitochondrial ribosomal protein S16 | Always | In 1 condition |
| MTM1myotubularin 1 | Always | In 2 conditions |
| MYT1Lmyelin transcription factor 1 like | Always | In 2 conditions |
| NPAP1nuclear pore associated protein 1 | Always | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Always | In 1 condition |
| ODC1ornithine decarboxylase 1 | Always | In 2 conditions |
| PDSS2decaprenyl diphosphate synthase subunit 2 | Always | In 1 condition |
| PGAP1post-GPI attachment to proteins inositol deacylase 1 | Always | In 1 condition |
| PIEZO2piezo type mechanosensitive ion channel component 2 | Always | In 1 condition |
| PLCB3phospholipase C beta 3 | Always | In 1 condition |
| POMKprotein O-mannose kinase | Always | In 2 conditions |
| POMT1protein O-mannosyltransferase 1 | Always | In 3 conditions |
| POMT2protein O-mannosyltransferase 2 | Always | In 1 condition |
| PRKAR1Bprotein kinase cAMP-dependent type I regulatory subunit beta | Always | In 1 condition |
| PWAR1Prader Willi/Angelman region RNA 1 | Always | In 1 condition |
Show 147 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| PWRN1Prader-Willi region non-protein coding RNA 1 | Always | In 1 condition |
| RBL2RB transcriptional corepressor like 2 | Always | In 1 condition |
| RYR1ryanodine receptor 1 | Always | In 3 conditions |
| SLC25A22solute carrier family 25 member 22 | Always | In 1 condition |
| SNORD115-1small nucleolar RNA, C/D box 115-1 | Always | In 1 condition |
| SNORD116-1small nucleolar RNA, C/D box 116-1 | Always | In 1 condition |
| SONSON DNA and RNA binding protein | Always | In 1 condition |
| SPTBN4spectrin beta, non-erythrocytic 4 | Always | In 1 condition |
| TGFB3transforming growth factor beta 3 | Always | In 1 condition |
| TIMM22translocase of inner mitochondrial membrane 22 | Always | In 1 condition |
| TSFMTs translation elongation factor, mitochondrial | Always | In 1 condition |
| UQCC2ubiquinol-cytochrome c reductase complex assembly factor 2 | Always | In 1 condition |
| ACTA1actin alpha 1, skeletal muscle | Very often (80–99%) | In 4 conditions |
| HADHhydroxyacyl-CoA dehydrogenase | Very often (80–99%) | In 1 condition |
| HNF1AHNF1 homeobox A | Very often (80–99%) | In 1 condition |
| HNF4Ahepatocyte nuclear factor 4 alpha | Very often (80–99%) | In 1 condition |
| HSD17B4hydroxysteroid 17-beta dehydrogenase 4 | Very often (80–99%) | In 1 condition |
| KAT6Alysine acetyltransferase 6A | Very often (80–99%) | In 2 conditions |
| NEXMIFneurite extension and migration factor | Very often (80–99%) | In 1 condition |
| NR4A2nuclear receptor subfamily 4 group A member 2 | Very often (80–99%) | In 1 condition |
| OCRLOCRL inositol polyphosphate-5-phosphatase | Very often (80–99%) | In 2 conditions |
| PLOD1procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 | Very often (80–99%) | In 1 condition |
| PPP2R5Dprotein phosphatase 2 regulatory subunit B'delta | Very often (80–99%) | In 1 condition |
| SCN4Asodium voltage-gated channel alpha subunit 4 | Very often (80–99%) | In 4 conditions |
| SH2B1SH2B adaptor protein 1 | Very often (80–99%) | In 1 condition |
| SHANK3SH3 and multiple ankyrin repeat domains 3 | Very often (80–99%) | In 1 condition |
| SUMF1sulfatase modifying factor 1 | Very often (80–99%) | In 2 conditions |
| TBCKTBC1 domain containing kinase | Very often (80–99%) | In 1 condition |
| TBR1T-box brain transcription factor 1 | Very often (80–99%) | In 1 condition |
| TUBA8tubulin alpha 8 | Very often (80–99%) | In 1 condition |
| ATXN7ataxin 7 | Often (30–79%) | In 1 condition |
| B3GALT6beta-1,3-galactosyltransferase 6 | Often (30–79%) | In 1 condition |
| CAMTA1calmodulin binding transcription activator 1 | Often (30–79%) | In 2 conditions |
| CASKcalcium/calmodulin dependent serine protein kinase | Often (30–79%) | In 1 condition |
| CFL2cofilin 2 | Often (30–79%) | In 1 condition |
| CLPBClpB family mitochondrial disaggregase | Often (30–79%) | In 1 condition |
| COL12A1collagen type XII alpha 1 chain | Often (30–79%) | In 2 conditions |
| CRPPACDP-L-ribitol pyrophosphorylase A | Often (30–79%) | In 1 condition |
| DLK1delta like non-canonical Notch ligand 1 | Often (30–79%) | In 1 condition |
| DMPKDM1 protein kinase | Often (30–79%) | In 1 condition |
| ERCC6L2ERCC excision repair 6 like 2 | Often (30–79%) | In 1 condition |
| H1-4H1.4 linker histone, cluster member | Often (30–79%) | In 1 condition |
| KCNK9potassium two pore domain channel subfamily K member 9 | Often (30–79%) | In 1 condition |
| KLHL40kelch like family member 40 | Often (30–79%) | In 1 condition |
| KLHL41kelch like family member 41 | Often (30–79%) | In 2 conditions |
| KNSTRNkinetochore localized astrin (SPAG5) binding protein | Often (30–79%) | In 1 condition |
| LMOD3leiomodin 3 | Often (30–79%) | In 2 conditions |
| MADDMAP kinase activating death domain | Often (30–79%) | In 2 conditions |
| MEG3maternally expressed 3 | Often (30–79%) | In 1 condition |
| NADK2NAD kinase 2, mitochondrial | Often (30–79%) | In 1 condition |
| NDNnecdin, MAGE family member | Often (30–79%) | In 1 condition |
| NEBnebulin | Often (30–79%) | In 3 conditions |
| NFIXnuclear factor I X | Often (30–79%) | In 1 condition |
| NONOnon-POU domain containing octamer binding | Often (30–79%) | In 1 condition |
| PDP1pyruvate dehydrogenase phosphatase catalytic subunit 1 | Often (30–79%) | In 1 condition |
| PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | Often (30–79%) | In 1 condition |
| POU4F1POU class 4 homeobox 1 | Often (30–79%) | In 1 condition |
| PTRH2peptidyl-tRNA hydrolase 2 | Often (30–79%) | In 1 condition |
| PURApurine rich element binding protein A | Often (30–79%) | In 2 conditions |
| RPL10ribosomal protein L10 | Often (30–79%) | In 1 condition |
| RTL1retrotransposon Gag like 1 | Often (30–79%) | In 1 condition |
| SIM1SIM bHLH transcription factor 1 | Often (30–79%) | In 2 conditions |
| SNRPNsmall nuclear ribonucleoprotein polypeptide N | Often (30–79%) | In 2 conditions |
| SPOPspeckle type BTB/POZ protein | Often (30–79%) | In 1 condition |
| TNNT1troponin T1, slow skeletal type | Often (30–79%) | In 1 condition |
| TPM2tropomyosin 2 | Often (30–79%) | In 1 condition |
| USP7ubiquitin specific peptidase 7 | Often (30–79%) | In 1 condition |
| WACWW domain containing adaptor with coiled-coil | Often (30–79%) | In 2 conditions |
| WDR19WD repeat domain 19 | Often (30–79%) | In 1 condition |
| ZNF148zinc finger protein 148 | Often (30–79%) | In 1 condition |
| AFG2AAAA ATPase AFG2A | Sometimes (5–29%) | In 1 condition |
| ARID1BAT-rich interaction domain 1B | Sometimes (5–29%) | In 1 condition |
| BCS1LBCS1 ubiquinol-cytochrome c reductase complex chaperone | Sometimes (5–29%) | In 1 condition |
| CDKL5cyclin dependent kinase like 5 | Sometimes (5–29%) | In 1 condition |
| CWC27CWC27 spliceosome associated cyclophilin | Sometimes (5–29%) | In 1 condition |
| EIF5Aeukaryotic translation initiation factor 5A | Sometimes (5–29%) | In 1 condition |
| GABBR2gamma-aminobutyric acid type B receptor subunit 2 | Sometimes (5–29%) | In 1 condition |
| GATA6GATA binding protein 6 | Sometimes (5–29%) | In 1 condition |
| GRIA4glutamate ionotropic receptor AMPA type subunit 4 | Sometimes (5–29%) | In 1 condition |
| LAMA2laminin subunit alpha 2 | Sometimes (5–29%) | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Sometimes (5–29%) | In 1 condition |
| NTNG1netrin G1 | Sometimes (5–29%) | In 1 condition |
| PAFAH1B1platelet activating factor acetylhydrolase 1b regulatory subunit 1 | Sometimes (5–29%) | In 1 condition |
| PDE4Dphosphodiesterase 4D | Sometimes (5–29%) | In 1 condition |
| PHIPPHIP subunit of CUL4-Ring ligase complex | Sometimes (5–29%) | In 1 condition |
| PRDM5PR/SET domain 5 | Sometimes (5–29%) | In 1 condition |
| PYROXD1pyridine nucleotide-disulphide oxidoreductase domain 1 | Sometimes (5–29%) | In 1 condition |
| SLC16A2solute carrier family 16 member 2 | Sometimes (5–29%) | In 2 conditions |
| SLF2SMC5/6 complex localization factor 2 | Sometimes (5–29%) | In 1 condition |
| SMC1Astructural maintenance of chromosomes 1A | Sometimes (5–29%) | In 1 condition |
| STAG1STAG1 cohesin complex component | Sometimes (5–29%) | In 1 condition |
| SYNE1spectrin repeat containing nuclear envelope protein 1 | Sometimes (5–29%) | In 1 condition |
| TMEM260transmembrane protein 260 | Sometimes (5–29%) | In 1 condition |
| VMA21vacuolar ATPase assembly factor VMA21 | Sometimes (5–29%) | In 1 condition |
| ZNF469zinc finger protein 469 | Sometimes (5–29%) | In 1 condition |
| DNAJC19DnaJ heat shock protein family (Hsp40) member C19 | Rarely (1–4%) | In 1 condition |
| MT-TEmitochondrially encoded tRNA-Glu (GAA/G) | Rarely (1–4%) | In 1 condition |
| ALG11ALG11 alpha-1,2-mannosyltransferase | Not recorded | In 1 condition |
| AP4M1adaptor related protein complex 4 subunit mu 1 | Not recorded | In 1 condition |
| ARXaristaless related homeobox | Not recorded | In 1 condition |
| ATP2B3ATPase plasma membrane Ca2+ transporting 3 | Not recorded | In 1 condition |
| BIN1bridging integrator 1 | Not recorded | In 1 condition |
| CCDC174coiled-coil domain containing 174 | Not recorded | In 1 condition |
| CHRNA1cholinergic receptor nicotinic alpha 1 subunit | Not recorded | In 1 condition |
| CHRNB1cholinergic receptor nicotinic beta 1 subunit | Not recorded | In 2 conditions |
| CHRNDcholinergic receptor nicotinic delta subunit | Not recorded | In 1 condition |
| CHRNEcholinergic receptor nicotinic epsilon subunit | Not recorded | In 1 condition |
| CNTN1contactin 1 | Not recorded | In 1 condition |
| COL6A1collagen type VI alpha 1 chain | Not recorded | In 2 conditions |
| CPT2carnitine palmitoyltransferase 2 | Not recorded | In 1 condition |
| DLATdihydrolipoamide S-acetyltransferase | Not recorded | In 1 condition |
| EARS2glutamyl-tRNA synthetase 2, mitochondrial | Not recorded | In 1 condition |
| EGR2early growth response 2 | Not recorded | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Not recorded | In 1 condition |
| FLNAfilamin A | Not recorded | In 1 condition |
| FOXG1forkhead box G1 | Not recorded | In 1 condition |
| GATAD2BGATA zinc finger domain containing 2B | Not recorded | In 1 condition |
| GLYCTKglycerate kinase | Not recorded | In 1 condition |
| GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta | Not recorded | In 1 condition |
| IER3IP1immediate early response 3 interacting protein 1 | Not recorded | In 1 condition |
| LYRM4LYR motif containing 4 | Not recorded | In 1 condition |
| MED12mediator complex subunit 12 | Not recorded | In 1 condition |
| MEGF10multiple EGF like domains 10 | Not recorded | In 1 condition |
| MUSKmuscle associated receptor tyrosine kinase | Not recorded | In 1 condition |
| PCLOpiccolo presynaptic cytomatrix protein | Not recorded | In 1 condition |
| PDHXpyruvate dehydrogenase complex component X | Not recorded | In 1 condition |
| PEX1peroxisomal biogenesis factor 1 | Not recorded | In 1 condition |
| PEX10peroxisomal biogenesis factor 10 | Not recorded | In 1 condition |
| PEX16peroxisomal biogenesis factor 16 | Not recorded | In 1 condition |
| PEX2peroxisomal biogenesis factor 2 | Not recorded | In 1 condition |
| PEX26peroxisomal biogenesis factor 26 | Not recorded | In 1 condition |
| PEX6peroxisomal biogenesis factor 6 | Not recorded | In 1 condition |
| PRPS1phosphoribosyl pyrophosphate synthetase 1 | Not recorded | In 1 condition |
| RAPSNreceptor associated protein of the synapse | Not recorded | In 1 condition |
| SDHAsuccinate dehydrogenase complex flavoprotein subunit A | Not recorded | In 1 condition |
| SLC12A6solute carrier family 12 member 6 | Not recorded | In 1 condition |
| SLC25A46solute carrier family 25 member 46 | Not recorded | In 1 condition |
| SLC6A8solute carrier family 6 member 8 | Not recorded | In 1 condition |
| SOX10SRY-box transcription factor 10 | Not recorded | In 1 condition |
| SYT1synaptotagmin 1 | Not recorded | In 1 condition |
| TAF6TATA-box binding protein associated factor 6 | Not recorded | In 1 condition |
| TMCO1transmembrane and coiled-coil domains 1 | Not recorded | In 1 condition |
| TPM3tropomyosin 3 | Not recorded | In 1 condition |
| TUFMTu translation elongation factor, mitochondrial | Not recorded | In 1 condition |
| UPB1beta-ureidopropionase 1 | Not recorded | In 1 condition |
| VPS13Bvacuolar protein sorting 13 homolog B | Not recorded | In 1 condition |
| VPS53VPS53 subunit of GARP complex | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Who We HelpOur ScienceProductsOutcomes
Log InAskGet Startedfrom $449
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks