Trait
Broad big toe
Clinical name: Broad hallux
Visible increase in width of the hallux without an increase in the dorso-ventral dimension.
Summary
- Also called
- Wide big toe, Abnormally broad great toes, Broad great toe, Broad great toes, Broad halluces
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test87 genes linked to Broad big toe
Changes in these genes cause rare conditions in which Broad big toe is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ALDH6A1aldehyde dehydrogenase 6 family member A1 | Always | In 1 condition |
| ATXN7L3ataxin 7 like 3 | Always | In 1 condition |
| C2CD3C2 domain containing 3 centriole elongation regulator | Always | In 2 conditions |
| CCDC22CCC complex scaffolding subunit CCDC22 | Always | In 1 condition |
| DNM1Ldynamin 1L | Always | In 1 condition |
| EBPEBP cholestenol delta-isomerase | Always | In 2 conditions |
| FGFR2fibroblast growth factor receptor 2 | Always | In 4 conditions |
| GLI3GLI family zinc finger 3 | Always | In 2 conditions |
| HOXA13homeobox A13 | Always | In 1 condition |
| HYAL2hyaluronidase 2 | Always | In 1 condition |
| IL11RAinterleukin 11 receptor subunit alpha | Always | In 1 condition |
| KIAA0753KIAA0753 | Always | In 1 condition |
| KMT2Blysine methyltransferase 2B | Always | In 1 condition |
| MED12mediator complex subunit 12 | Always | In 1 condition |
| NPR2natriuretic peptide receptor 2 | Always | In 1 condition |
| NXNnucleoredoxin | Always | In 1 condition |
| PIGOphosphatidylinositol glycan anchor biosynthesis class O | Always | In 1 condition |
| SLC13A1solute carrier family 13 member 1 | Always | In 1 condition |
| TWIST1twist family bHLH transcription factor 1 | Always | In 1 condition |
| UBAP2Lubiquitin associated protein 2 like | Always | In 1 condition |
| UBE2Aubiquitin conjugating enzyme E2 A | Always | In 1 condition |
| WDPCPWD repeat containing planar cell polarity effector | Always | In 1 condition |
| CREBBPCREB binding lysine acetyltransferase | Very often (80–99%) | In 4 conditions |
| DVL1dishevelled segment polarity protein 1 | Very often (80–99%) | In 1 condition |
| EP300EP300 lysine acetyltransferase | Very often (80–99%) | In 3 conditions |
| NOGnoggin | Very often (80–99%) | In 1 condition |
| PDE4Dphosphodiesterase 4D | Very often (80–99%) | In 1 condition |
| ASPHaspartate beta-hydroxylase | Often (30–79%) | In 1 condition |
| BCORBCL6 corepressor | Often (30–79%) | In 1 condition |
| BPTFbromodomain PHD finger transcription factor | Often (30–79%) | In 1 condition |
| CHST11carbohydrate sulfotransferase 11 | Often (30–79%) | In 1 condition |
| FGFR3fibroblast growth factor receptor 3 | Often (30–79%) | In 1 condition |
| GPC4glypican 4 | Often (30–79%) | In 1 condition |
| HNRNPRheterogeneous nuclear ribonucleoprotein R | Often (30–79%) | In 1 condition |
| LBRlamin B receptor | Often (30–79%) | In 1 condition |
| NAA10N-alpha-acetyltransferase 10, NatA catalytic subunit | Often (30–79%) | In 2 conditions |
| NBASNBAS subunit of NRZ tethering complex | Often (30–79%) | In 1 condition |
| NEK1NIMA related kinase 1 | Often (30–79%) | In 1 condition |
| PPP2R1Aprotein phosphatase 2 scaffold subunit Aalpha | Often (30–79%) | In 2 conditions |
| ROR2ROR family WNT receptor 2 | Often (30–79%) | In 1 condition |
Show 47 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SCNM1sodium channel modifier 1 | Often (30–79%) | In 1 condition |
| SETBP1SET binding protein 1 | Often (30–79%) | In 1 condition |
| SIAH1siah E3 ubiquitin protein ligase 1 | Often (30–79%) | In 1 condition |
| TAF6TATA-box binding protein associated factor 6 | Often (30–79%) | In 1 condition |
| ADNPactivity dependent neuroprotector homeobox | Sometimes (5–29%) | In 2 conditions |
| CACHD1cache domain containing 1 | Sometimes (5–29%) | In 1 condition |
| CDK10cyclin dependent kinase 10 | Sometimes (5–29%) | In 1 condition |
| COL2A1collagen type II alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| CSNK2A1casein kinase 2 alpha 1 | Sometimes (5–29%) | In 1 condition |
| HIVEP2HIVEP zinc finger 2 | Sometimes (5–29%) | In 1 condition |
| KMT2Dlysine methyltransferase 2D | Sometimes (5–29%) | In 1 condition |
| LRP4LDL receptor related protein 4 | Sometimes (5–29%) | In 1 condition |
| PUF60poly(U) binding splicing factor 60 | Sometimes (5–29%) | In 1 condition |
| PYCR2pyrroline-5-carboxylate reductase 2 | Sometimes (5–29%) | In 1 condition |
| RHOAras homolog family member A | Sometimes (5–29%) | In 1 condition |
| RNU5B-1RNA, U5B small nuclear 1 | Sometimes (5–29%) | In 1 condition |
| SATB2SATB homeobox 2 | Sometimes (5–29%) | In 1 condition |
| SLC6A1solute carrier family 6 member 1 | Sometimes (5–29%) | In 1 condition |
| SLC6A11solute carrier family 6 member 11 | Sometimes (5–29%) | In 1 condition |
| SMC1Astructural maintenance of chromosomes 1A | Sometimes (5–29%) | In 1 condition |
| TRPM3transient receptor potential cation channel subfamily M member 3 | Sometimes (5–29%) | In 1 condition |
| USP9Xubiquitin specific peptidase 9 X-linked | Sometimes (5–29%) | In 1 condition |
| ZEB2zinc finger E-box binding homeobox 2 | Sometimes (5–29%) | In 2 conditions |
| ACANaggrecan | Rarely (1–4%) | In 1 condition |
| FGF9fibroblast growth factor 9 | Rarely (1–4%) | In 1 condition |
| GJA5gap junction protein alpha 5 | Rarely (1–4%) | In 1 condition |
| GJA8gap junction protein alpha 8 | Rarely (1–4%) | In 1 condition |
| MARK2microtubule affinity regulating kinase 2 | Rarely (1–4%) | In 1 condition |
| ABCC9ATP binding cassette subfamily C member 9 | Not recorded | In 1 condition |
| BMP2bone morphogenetic protein 2 | Not recorded | In 1 condition |
| BMPR1Bbone morphogenetic protein receptor type 1B | Not recorded | In 1 condition |
| DLX5distal-less homeobox 5 | Not recorded | In 1 condition |
| EFNB1ephrin B1 | Not recorded | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Not recorded | In 2 conditions |
| FLNAfilamin A | Not recorded | In 3 conditions |
| GATA6GATA binding protein 6 | Not recorded | In 1 condition |
| GDF5growth differentiation factor 5 | Not recorded | In 1 condition |
| HOXD13homeobox D13 | Not recorded | In 1 condition |
| KCNH1potassium voltage-gated channel subfamily H member 1 | Not recorded | In 1 condition |
| MEIS2Meis homeobox 2 | Not recorded | In 1 condition |
| NKX2-5NK2 homeobox 5 | Not recorded | In 1 condition |
| NKX2-6NK2 homeobox 6 | Not recorded | In 1 condition |
| SF3B4splicing factor 3b subunit 4 | Not recorded | In 1 condition |
| SUMF1sulfatase modifying factor 1 | Not recorded | In 1 condition |
| TBX1T-box transcription factor 1 | Not recorded | In 1 condition |
| TNNT3troponin T3, fast skeletal type | Not recorded | In 1 condition |
| ZMIZ1zinc finger MIZ-type containing 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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