Trait
Gap between 1st and 2nd toes
Clinical name: Sandal gap
A widely spaced gap between the first toe (the great toe) and the second toe.
Summary
- Also called
- Gap between first and second toe, Increased space between first and second toes, Sandal gap between first and second toes, Wide space between 1st, 2nd toes, Wide space between first and second toes, Wide-spaced big toe, Widely spaced 1st-2nd toes, Widely spaced first and second toes, Widened gap 1st-2nd toes, Widened gap first and second toe, Space between great toe and second toe
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Gap between 1st and 2nd toes, and the rest of your genome, with one test.
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Get my Genome Test112 genes linked to Gap between 1st and 2nd toes
Changes in these genes cause rare conditions in which Gap between 1st and 2nd toes is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ALG12ALG12 alpha-1,6-mannosyltransferase | Always | In 2 conditions |
| ARID1AAT-rich interaction domain 1A | Always | In 1 condition |
| CILK1ciliogenesis associated kinase 1 | Always | In 2 conditions |
| DCPSdecapping enzyme, scavenger | Always | In 1 condition |
| DMRT2doublesex and mab-3 related transcription factor 2 | Always | In 1 condition |
| DSPdesmoplakin | Always | In 1 condition |
| ELFN1extracellular leucine rich repeat and fibronectin type III domain containing 1 | Always | In 1 condition |
| JKAMPJNK1/MAPK8 associated membrane protein | Always | In 1 condition |
| KDM2Blysine demethylase 2B | Always | In 1 condition |
| KDM6Blysine demethylase 6B | Always | In 1 condition |
| MBD5methyl-CpG binding domain protein 5 | Always | In 2 conditions |
| MED16mediator complex subunit 16 | Always | In 1 condition |
| MEIS2Meis homeobox 2 | Always | In 1 condition |
| SMARCA2SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 | Always | In 2 conditions |
| ATRATR checkpoint kinase | Very often (80–99%) | In 2 conditions |
| ATRIPATR interacting protein | Very often (80–99%) | In 1 condition |
| CENPEcentromere protein E | Very often (80–99%) | In 1 condition |
| CEP152centrosomal protein 152 | Very often (80–99%) | In 1 condition |
| CEP295centrosomal protein 295 | Very often (80–99%) | In 1 condition |
| CEP63centrosomal protein 63 | Very often (80–99%) | In 1 condition |
| CPAPcentrosome assembly and centriole elongation protein | Very often (80–99%) | In 1 condition |
| CUL4Bcullin 4B | Very often (80–99%) | In 2 conditions |
| DNA2DNA replication helicase/nuclease 2 | Very often (80–99%) | In 1 condition |
| FLNAfilamin A | Very often (80–99%) | In 2 conditions |
| NINninein | Very often (80–99%) | In 1 condition |
| NSMCE2NSE2 SUMO ligase component of SMC5/6 complex | Very often (80–99%) | In 1 condition |
| NUP85nucleoporin 85 | Very often (80–99%) | In 1 condition |
| PCNTpericentrin | Very often (80–99%) | In 1 condition |
| PLK4polo like kinase 4 | Very often (80–99%) | In 1 condition |
| RBBP8RB binding protein 8, endonuclease | Very often (80–99%) | In 1 condition |
| SMOC1SPARC related modular calcium binding 1 | Very often (80–99%) | In 2 conditions |
| TRAIPTRAF interacting protein | Very often (80–99%) | In 1 condition |
| VPS13Bvacuolar protein sorting 13 homolog B | Very often (80–99%) | In 1 condition |
| B3GAT3beta-1,3-glucuronyltransferase 3 | Often (30–79%) | In 1 condition |
| BCORBCL6 corepressor | Often (30–79%) | In 1 condition |
| BMP2bone morphogenetic protein 2 | Often (30–79%) | In 1 condition |
| CHST11carbohydrate sulfotransferase 11 | Often (30–79%) | In 1 condition |
| CHST3carbohydrate sulfotransferase 3 | Often (30–79%) | In 1 condition |
| CREBBPCREB binding lysine acetyltransferase | Often (30–79%) | In 2 conditions |
| CTCFCCCTC-binding factor | Often (30–79%) | In 1 condition |
Show 72 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| DDX59DEAD-box helicase 59 | Often (30–79%) | In 1 condition |
| EFNB1ephrin B1 | Often (30–79%) | In 1 condition |
| EP300EP300 lysine acetyltransferase | Often (30–79%) | In 1 condition |
| H4C9H4 clustered histone 9 | Often (30–79%) | In 1 condition |
| IFT43intraflagellar transport 43 | Often (30–79%) | In 1 condition |
| LTBP4latent transforming growth factor beta binding protein 4 | Often (30–79%) | In 1 condition |
| NBASNBAS subunit of NRZ tethering complex | Often (30–79%) | In 1 condition |
| NBNnibrin | Often (30–79%) | In 1 condition |
| NXNnucleoredoxin | Often (30–79%) | In 2 conditions |
| PIEZO2piezo type mechanosensitive ion channel component 2 | Often (30–79%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Often (30–79%) | In 2 conditions |
| PPFIA3PPFI scaffold protein A3 | Often (30–79%) | In 1 condition |
| PRKG2protein kinase cGMP-dependent 2 | Often (30–79%) | In 1 condition |
| SALL4spalt like transcription factor 4 | Often (30–79%) | In 2 conditions |
| SETD5SET domain containing 5 | Often (30–79%) | In 1 condition |
| SLC26A2solute carrier family 26 member 2 | Often (30–79%) | In 3 conditions |
| SMARCD2SWI/SNF related BAF chromatin remodeling complex subunit D2 | Often (30–79%) | In 1 condition |
| SVILsupervillin | Often (30–79%) | In 1 condition |
| TBC1D32TBC1 domain family member 32 | Often (30–79%) | In 1 condition |
| TCF20transcription factor 20 | Often (30–79%) | In 1 condition |
| ABL1ABL proto-oncogene 1, non-receptor tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| ADNPactivity dependent neuroprotector homeobox | Sometimes (5–29%) | In 2 conditions |
| AEBP1AE binding protein 1 | Sometimes (5–29%) | In 1 condition |
| ARID1BAT-rich interaction domain 1B | Sometimes (5–29%) | In 1 condition |
| BCL11ABCL11 transcription factor A | Sometimes (5–29%) | In 1 condition |
| BCRBCR activator of RhoGEF and GTPase | Sometimes (5–29%) | In 1 condition |
| BPTFbromodomain PHD finger transcription factor | Sometimes (5–29%) | In 1 condition |
| COL11A2collagen type XI alpha 2 chain | Sometimes (5–29%) | In 1 condition |
| COL1A2collagen type I alpha 2 chain | Sometimes (5–29%) | In 1 condition |
| COX7Bcytochrome c oxidase subunit 7B | Sometimes (5–29%) | In 1 condition |
| CRKLCRK like proto-oncogene, adaptor protein | Sometimes (5–29%) | In 1 condition |
| DPM1dolichyl-phosphate mannosyltransferase subunit 1, catalytic | Sometimes (5–29%) | In 1 condition |
| EBF3EBF transcription factor 3 | Sometimes (5–29%) | In 1 condition |
| ESCO2establishment of sister chromatid cohesion N-acetyltransferase 2 | Sometimes (5–29%) | In 1 condition |
| EZH2enhancer of zeste 2 polycomb repressive complex 2 subunit | Sometimes (5–29%) | In 1 condition |
| FBXO11F-box protein 11 | Sometimes (5–29%) | In 1 condition |
| FBXW11F-box and WD repeat domain containing 11 | Sometimes (5–29%) | In 1 condition |
| HEATR3HEAT repeat containing 3 | Sometimes (5–29%) | In 1 condition |
| KAT6Alysine acetyltransferase 6A | Sometimes (5–29%) | In 1 condition |
| MAN2C1mannosidase alpha class 2C member 1 | Sometimes (5–29%) | In 1 condition |
| MAPK1mitogen-activated protein kinase 1 | Sometimes (5–29%) | In 1 condition |
| MTX2metaxin 2 | Sometimes (5–29%) | In 1 condition |
| NAA10N-alpha-acetyltransferase 10, NatA catalytic subunit | Sometimes (5–29%) | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Sometimes (5–29%) | In 1 condition |
| RAI1retinoic acid induced 1 | Sometimes (5–29%) | In 1 condition |
| RELREL proto-oncogene, NF-kB subunit | Sometimes (5–29%) | In 1 condition |
| RFX7regulatory factor X7 | Sometimes (5–29%) | In 1 condition |
| RHOAras homolog family member A | Sometimes (5–29%) | In 1 condition |
| RNU5B-1RNA, U5B small nuclear 1 | Sometimes (5–29%) | In 1 condition |
| ROR2ROR family WNT receptor 2 | Sometimes (5–29%) | In 1 condition |
| SATB1SATB homeobox 1 | Sometimes (5–29%) | In 1 condition |
| SETBP1SET binding protein 1 | Sometimes (5–29%) | In 1 condition |
| SLC32A1solute carrier family 32 member 1 | Sometimes (5–29%) | In 1 condition |
| SUZ12SUZ12 polycomb repressive complex 2 subunit | Sometimes (5–29%) | In 1 condition |
| TBX4T-box transcription factor 4 | Sometimes (5–29%) | In 2 conditions |
| TRAF7TNF receptor associated factor 7 | Sometimes (5–29%) | In 1 condition |
| TRIOtrio Rho guanine nucleotide exchange factor | Sometimes (5–29%) | In 1 condition |
| UGGT1UDP-glucose glycoprotein glucosyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| WBP4WW domain binding protein 4 | Sometimes (5–29%) | In 1 condition |
| XPO1exportin 1 | Sometimes (5–29%) | In 1 condition |
| YY1YY1 transcription factor | Sometimes (5–29%) | In 2 conditions |
| CANT1calcium activated nucleotidase 1 | Not recorded | In 1 condition |
| FLNBfilamin B | Not recorded | In 1 condition |
| GALNT2polypeptide N-acetylgalactosaminyltransferase 2 | Not recorded | In 1 condition |
| GMNNgeminin DNA replication inhibitor | Not recorded | In 1 condition |
| HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2 | Not recorded | In 1 condition |
| IFT52intraflagellar transport 52 | Not recorded | In 1 condition |
| IFT57intraflagellar transport 57 | Not recorded | In 1 condition |
| IGF1Rinsulin like growth factor 1 receptor | Not recorded | In 1 condition |
| SMARCE1SWI/SNF related BAF chromatin remodeling complex subunit E1 | Not recorded | In 1 condition |
| TNNT3troponin T3, fast skeletal type | Not recorded | In 1 condition |
| TRIP12thyroid hormone receptor interactor 12 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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