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Gene

PLXNA3

plexin A3

Summary

Cytogenetic location
Xq28
Coordinates
Chromosome X: 154,458,281–154,477,779 (GRCh38)
Exons
33 exons across 19.5 kb
Protein
1,871 amino acids
Also known as
SEX, XAP-6, 6.3, Plxn3
Previous symbols
PLXN4
MANE Select transcript
ENST00000369682.4NM_017514.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hypogonadotropic Hypogonadism

    • Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis.

      • 1 GenCC submitter rates it definitive or strong

How PLXNA3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome X, with a bracket where PLXNA3 sits. PLXNA3 and 34 genes near it on chromosome X, from 153,968,030 to 154,968,029.Chromosome XXq28p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q28154 Mb154.2 Mb154.4 Mb154.6 Mb154.8 MbHCFC1: 153,946,434–153,972,427, reverse strandHCFC1TMEM187: 153,972,290–153,983,194, forward strandTMEM187IRAK1: 154,010,501–154,020,650, reverse strandIRAK1MECP2: 154,021,573–154,137,103, reverse strandMECP2OPN1LW: 154,144,243–154,159,032, forward strandOPN1LWOPN1MW: 154,182,596–154,196,861, forward strandOPN1MWOPN1MW2: 154,219,756–154,233,286, forward strandOPN1MW2OPN1MW3: 154,257,582–154,271,090, forward strandOPN1MW3TEX28: 154,271,265–154,295,853, reverse strandTEX28TKTL1: 154,295,795–154,330,350, forward strandTKTL1FLNA: 154,348,524–154,374,643, reverse strandFLNAEMD: 154,379,205–154,381,574, forward strandEMDRPL10: 154,389,955–154,409,168, forward strandRPL10DNASE1L1: 154,401,236–154,412,119, reverse strandTAFAZZIN: 154,409,456–154,421,726, forward strandTAFAZZINATP6AP1: 154,428,618–154,436,517, forward strandGDI1: 154,436,600–154,443,467, forward strandFAM50A: 154,444,103–154,450,655, forward strandFAM50APLXNA3: 154,458,281–154,477,779, forward strandPLXNA3LAGE3: 154,477,598–154,479,291, reverse strandLAGE3UBL4A: 154,483,717–154,486,661, reverse strandUBL4ASLC10A3: 154,487,306–154,490,690, reverse strandFAM3A: 154,505,019–154,516,882, reverse strandG6PD: 154,517,825–154,547,584, reverse strandG6PDIKBKG: 154,541,179–154,568,543, forward strandIKBKGCTAG1A: 154,585,133–154,586,816, forward strandCTAG1ACTAG1B: 154,617,609–154,619,282, reverse strandCTAG1BCTAG2: 154,651,972–154,653,579, reverse strandCTAG2GAB3: 154,675,249–154,751,583, reverse strandGAB3DKC1: 154,762,741–154,777,697, forward strandDKC1MPP1: 154,778,684–154,821,039, reverse strandMPP1SMIM9: 154,823,348–154,834,662, reverse strandSMIM9F8: 154,835,788–155,026,940, reverse strandF8H2AB1: 154,884,972–154,885,558, forward strandH2AB1F8A1: 154,886,355–154,888,061, forward strandF8A1Diagram of PLXNA3: 33 exons on the forward strand of chromosome XExon 1: 154,458,281–154,458,428, 148 basesExon 2: 154,460,157–154,460,777, 621 basesExon 3: 154,461,099–154,461,638, 540 basesExon 4: 154,462,128–154,462,310, 183 basesExon 5: 154,463,391–154,463,519, 129 basesExon 6: 154,463,590–154,463,690, 101 basesExon 7: 154,463,951–154,464,074, 124 basesExon 8: 154,464,157–154,464,313, 157 basesExon 9: 154,464,402–154,464,501, 100 basesExon 10: 154,464,754–154,464,868, 115 basesExon 11: 154,465,018–154,465,218, 201 basesExon 12: 154,465,424–154,465,520, 97 basesExon 13: 154,465,657–154,465,847, 191 basesExon 14: 154,465,935–154,466,080, 146 basesExon 15: 154,466,150–154,466,270, 121 basesExon 16: 154,466,376–154,466,512, 137 basesExon 17: 154,466,623–154,466,793, 171 basesExon 18: 154,467,057–154,467,150, 94 basesExon 19: 154,467,232–154,467,471, 240 basesExon 20: 154,467,545–154,467,688, 144 basesExon 21: 154,467,767–154,468,001, 235 basesExon 22: 154,468,082–154,468,224, 143 basesExon 23: 154,468,303–154,468,559, 257 basesExon 24: 154,468,663–154,468,729, 67 basesExon 25: 154,468,823–154,468,969, 147 basesExon 26: 154,469,056–154,469,215, 160 basesExon 27: 154,469,379–154,469,482, 104 basesExon 28: 154,469,688–154,469,784, 97 basesExon 29: 154,469,977–154,470,167, 191 basesExon 30: 154,470,442–154,470,611, 170 basesExon 31: 154,471,105–154,471,317, 213 basesExon 32: 154,471,488–154,471,638, 151 basesExon 33: 154,472,590–154,477,779, 5,190 bases151015202530335′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 10.9 kb of the gene's 19.5 kb; 5,616 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PLXNA3 gene: plexin A3. Retrieved 16 October 2026, from https://dantelabs.com/genes/plxna3

Vancouver

Dante Labs. PLXNA3 gene: plexin A3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/plxna3

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