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Gene

ARHGAP4

Rho GTPase activating protein 4

Summary

Cytogenetic location
Xq28
Coordinates
Chromosome X: 153,907,378–153,926,264 (GRCh38)
Exons
22 exons across 18.9 kb
Protein
946 amino acids
Also known as
KIAA0131, C1, p115, RhoGAP4, SrGAP4
MANE Select transcript
ENST00000350060.10NM_001666.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads ARHGAP4 yet. The test sequences your whole genome, so your data includes it all the same.

How ARHGAP4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome X, with a bracket where ARHGAP4 sits. ARHGAP4 and 36 genes near it on chromosome X, from 153,416,821 to 154,416,820.Chromosome XXq28p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q28153.6 Mb153.8 Mb154 Mb154.2 Mb154.4 MbZFP92: 153,411,434–153,426,481, forward strandZFP92TREX2: 153,444,473–153,470,592, reverse strandTREX2HAUS7: 153,447,655–153,495,529, reverse strandHAUS7BGN: 153,488,654–153,510,711, forward strandBGNATP2B3: 153,517,620–153,582,939, forward strandATP2B3CCNQ: 153,587,925–153,600,045, reverse strandCCNQDUSP9: 153,642,397–153,651,326, forward strandDUSP9PNCK: 153,669,730–153,689,033, reverse strandPNCKSLC6A8: 153,687,914–153,696,591, forward strandSLC6A8BCAP31: 153,698,006–153,725,957, reverse strandBCAP31ABCD1: 153,724,495–153,744,755, forward strandABCD1PLXNB3: 153,764,179–153,779,346, forward strandSRPK3: 153,781,001–153,785,768, forward strandSRPK3IDH3G: 153,785,735–153,794,535, reverse strandIDH3GSSR4: 153,793,516–153,798,510, forward strandSSR4PDZD4: 153,802,161–153,830,935, reverse strandPDZD4L1CAM: 153,861,511–153,886,204, reverse strandL1CAM: 153,872,221–153,909,223, reverse strandAVPR2: 153,902,531–153,907,169, forward strandAVPR2ARHGAP4: 153,907,378–153,926,264, reverse strandARHGAP4NAA10: 153,928,799–153,935,083, reverse strandNAA10RENBP: 153,935,269–153,944,688, reverse strandRENBPHCFC1: 153,946,434–153,972,427, reverse strandHCFC1TMEM187: 153,972,290–153,983,194, forward strandIRAK1: 154,010,501–154,020,650, reverse strandIRAK1MECP2: 154,021,573–154,137,103, reverse strandMECP2OPN1LW: 154,144,243–154,159,032, forward strandOPN1LWOPN1MW: 154,182,596–154,196,861, forward strandOPN1MWOPN1MW2: 154,219,756–154,233,286, forward strandOPN1MW2OPN1MW3: 154,257,582–154,271,090, forward strandOPN1MW3TEX28: 154,271,265–154,295,853, reverse strandTEX28TKTL1: 154,295,795–154,330,350, forward strandTKTL1FLNA: 154,348,524–154,374,643, reverse strandFLNAEMD: 154,379,205–154,381,574, forward strandEMDRPL10: 154,389,955–154,409,168, forward strandRPL10DNASE1L1: 154,401,236–154,412,119, reverse strandDNASE1L1TAFAZZIN: 154,409,456–154,421,726, forward strandDiagram of ARHGAP4: 22 exons on the reverse strand of chromosome XExon 22: 153,907,378–153,907,962, 585 basesExon 21: 153,909,070–153,909,169, 100 basesExon 20: 153,909,443–153,909,535, 93 basesExon 19: 153,909,741–153,909,924, 184 basesExon 18: 153,910,012–153,910,085, 74 basesExon 17: 153,910,171–153,910,404, 234 basesExon 16: 153,910,506–153,910,611, 106 basesExon 15: 153,910,700–153,910,834, 135 basesExon 14: 153,910,922–153,910,999, 78 basesExon 13: 153,911,129–153,911,189, 61 basesExon 12: 153,912,700–153,912,802, 103 basesExon 11: 153,913,024–153,913,051, 28 basesExon 10: 153,913,218–153,913,302, 85 basesExon 9: 153,913,409–153,913,600, 192 basesExon 8: 153,913,778–153,913,879, 102 basesExon 7: 153,918,832–153,919,053, 222 basesExon 6: 153,919,155–153,919,283, 129 basesExon 5: 153,920,626–153,920,808, 183 basesExon 4: 153,921,097–153,921,159, 63 basesExon 3: 153,921,365–153,921,527, 163 basesExon 2: 153,921,605–153,921,809, 205 basesExon 1: 153,926,136–153,926,264, 129 bases22201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.3 kb of the gene's 18.9 kb; 2,841 of those bases code for the protein.

How a genome test reads ARHGAP4

1

position in ARHGAP4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 18.9 kb of ARHGAP4, introns included, not only the 3.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ARHGAP4 gene: Rho GTPase activating protein 4. Retrieved 17 October 2026, from https://dantelabs.com/genes/arhgap4

Vancouver

Dante Labs. ARHGAP4 gene: Rho GTPase activating protein 4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/arhgap4

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