Trait
Monobrow
Clinical name: Synophrys
Meeting of the medial eyebrows in the midline.
Summary
- Also called
- Unibrow, Synophris
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Monobrow, and the rest of your genome, with one test.
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Get my Genome Test219 genes linked to Monobrow
Changes in these genes cause rare conditions in which Monobrow is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AFF4ALF transcription elongation factor 4 | Always | In 2 conditions |
| AMMECR1AMMECR nuclear protein 1 | Always | In 1 condition |
| ASH1LASH1 like histone lysine methyltransferase | Always | In 1 condition |
| CWF19L1CWF19 like cell cycle control factor 1 | Always | In 2 conditions |
| EIF4A2eukaryotic translation initiation factor 4A2 | Always | In 1 condition |
| ELFN1extracellular leucine rich repeat and fibronectin type III domain containing 1 | Always | In 1 condition |
| EMC10ER membrane protein complex subunit 10 | Always | In 1 condition |
| ESAMendothelial cell adhesion molecule | Always | In 1 condition |
| FBXO28F-box protein 28 | Always | In 1 condition |
| FLNAfilamin A | Always | In 1 condition |
| GTF3C3general transcription factor IIIC subunit 3 | Always | In 1 condition |
| HDAC8histone deacetylase 8 | Always | In 2 conditions |
| HID1HID1 domain containing | Always | In 1 condition |
| HSPA9heat shock protein family A (Hsp70) member 9 | Always | In 1 condition |
| JKAMPJNK1/MAPK8 associated membrane protein | Always | In 1 condition |
| KDM6Blysine demethylase 6B | Always | In 1 condition |
| KMT2Alysine methyltransferase 2A | Always | In 2 conditions |
| KNL1kinetochore scaffold 1 | Always | In 1 condition |
| MAB21L1mab-21 like 1 | Always | In 2 conditions |
| MAP1Bmicrotubule associated protein 1B | Always | In 1 condition |
| NUDT2nudix hydrolase 2 | Always | In 1 condition |
| PAX3paired box 3 | Always | In 3 conditions |
| PLCB4phospholipase C beta 4 | Always | In 1 condition |
| SMC1Astructural maintenance of chromosomes 1A | Always | In 3 conditions |
| SMSspermine synthase | Always | In 2 conditions |
| TAF4TATA-box binding protein associated factor 4 | Always | In 1 condition |
| TAF6TATA-box binding protein associated factor 6 | Always | In 1 condition |
| TASP1taspase 1 | Always | In 1 condition |
| TMCO1transmembrane and coiled-coil domains 1 | Always | In 2 conditions |
| TMEM94transmembrane protein 94 | Always | In 1 condition |
| UBAP2Lubiquitin associated protein 2 like | Always | In 1 condition |
| UBE2Aubiquitin conjugating enzyme E2 A | Always | In 2 conditions |
| UBR5ubiquitin protein ligase E3 component n-recognin 5 | Always | In 1 condition |
| UQCC2ubiquinol-cytochrome c reductase complex assembly factor 2 | Always | In 1 condition |
| ZNF407zinc finger protein 407 | Always | In 1 condition |
| BRD4bromodomain containing 4 | Very often (80–99%) | In 2 conditions |
| CDH11cadherin 11 | Very often (80–99%) | In 2 conditions |
| CUL4Bcullin 4B | Very often (80–99%) | In 1 condition |
| FBXO31F-box protein 31 | Very often (80–99%) | In 1 condition |
| MAU2MAU2 sister chromatid cohesion factor | Very often (80–99%) | In 2 conditions |
Show 179 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| NIPBLNIPBL cohesin loading factor | Very often (80–99%) | In 2 conditions |
| RAD21RAD21 cohesin complex component | Very often (80–99%) | In 2 conditions |
| RAI1retinoic acid induced 1 | Very often (80–99%) | In 2 conditions |
| SMC3structural maintenance of chromosomes 3 | Very often (80–99%) | In 2 conditions |
| TRAPPC9trafficking protein particle complex subunit 9 | Very often (80–99%) | In 2 conditions |
| ACTBactin beta | Often (30–79%) | In 1 condition |
| ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif 3 | Often (30–79%) | In 1 condition |
| AFF3ALF transcription elongation factor 3 | Often (30–79%) | In 1 condition |
| AHDC1AT-hook DNA binding motif containing 1 | Often (30–79%) | In 1 condition |
| AIPAHR interacting HSP90 co-chaperone | Often (30–79%) | In 1 condition |
| ANKRD11ankyrin repeat domain 11 | Often (30–79%) | In 2 conditions |
| ARID2AT-rich interaction domain 2 | Often (30–79%) | In 1 condition |
| ASXL1ASXL transcriptional regulator 1 | Often (30–79%) | In 1 condition |
| ASXL2ASXL transcriptional regulator 2 | Often (30–79%) | In 1 condition |
| ATP6V1B2ATPase H+ transporting V1 subunit B2 | Often (30–79%) | In 1 condition |
| BCAS3BCAS3 microtubule associated cell migration factor | Often (30–79%) | In 1 condition |
| BICRABRD4 interacting chromatin remodeling complex associated protein | Often (30–79%) | In 1 condition |
| BMP2bone morphogenetic protein 2 | Often (30–79%) | In 1 condition |
| BORCS8BLOC-1 related complex subunit 8 | Often (30–79%) | In 1 condition |
| BPTFbromodomain PHD finger transcription factor | Often (30–79%) | In 1 condition |
| CACHD1cache domain containing 1 | Often (30–79%) | In 1 condition |
| CASP2caspase 2 | Often (30–79%) | In 1 condition |
| CCDC47coiled-coil domain containing 47 | Often (30–79%) | In 1 condition |
| CERT1ceramide transporter 1 | Often (30–79%) | In 1 condition |
| CLP1cleavage factor polyribonucleotide kinase subunit 1 | Often (30–79%) | In 1 condition |
| COX5Acytochrome c oxidase subunit 5A | Often (30–79%) | In 1 condition |
| DOCK7dedicator of cytokinesis 7 | Often (30–79%) | In 2 conditions |
| DYMdymeclin | Often (30–79%) | In 1 condition |
| EDN3endothelin 3 | Often (30–79%) | In 1 condition |
| EDNRBendothelin receptor type B | Often (30–79%) | In 1 condition |
| EHMT1euchromatic histone lysine methyltransferase 1 | Often (30–79%) | In 2 conditions |
| FGFR1fibroblast growth factor receptor 1 | Often (30–79%) | In 2 conditions |
| FHL1four and a half LIM domains 1 | Often (30–79%) | In 1 condition |
| FRA10AC1FRA10A associated CGG repeat 1 | Often (30–79%) | In 1 condition |
| FREM1FRAS1 related extracellular matrix 1 | Often (30–79%) | In 1 condition |
| GNSglucosamine (N-acetyl)-6-sulfatase | Often (30–79%) | In 1 condition |
| GPR101G protein-coupled receptor 101 | Often (30–79%) | In 1 condition |
| HEATR3HEAT repeat containing 3 | Often (30–79%) | In 1 condition |
| IL1RAPL1interleukin 1 receptor accessory protein like 1 | Often (30–79%) | In 1 condition |
| KATNB1katanin regulatory subunit B1 | Often (30–79%) | In 1 condition |
| KCNK4potassium two pore domain channel subfamily K member 4 | Often (30–79%) | In 1 condition |
| KCNN3potassium calcium-activated channel subfamily N member 3 | Often (30–79%) | In 1 condition |
| MASP1MBL associated serine protease 1 | Often (30–79%) | In 1 condition |
| MBD5methyl-CpG binding domain protein 5 | Often (30–79%) | In 1 condition |
| MITFmelanocyte inducing transcription factor | Often (30–79%) | In 2 conditions |
| NECTIN1nectin cell adhesion molecule 1 | Often (30–79%) | In 1 condition |
| NMNAT1nicotinamide nucleotide adenylyltransferase 1 | Often (30–79%) | In 1 condition |
| NOTCH3notch receptor 3 | Often (30–79%) | In 1 condition |
| OGTO-linked N-acetylglucosamine (GlcNAc) transferase | Often (30–79%) | In 1 condition |
| PACS2phosphofurin acidic cluster sorting protein 2 | Often (30–79%) | In 1 condition |
| PAN2poly(A) specific ribonuclease subunit PAN2 | Often (30–79%) | In 1 condition |
| PHIPPHIP subunit of CUL4-Ring ligase complex | Often (30–79%) | In 2 conditions |
| POLR3ARNA polymerase III subunit A | Often (30–79%) | In 1 condition |
| PPFIA3PPFI scaffold protein A3 | Often (30–79%) | In 1 condition |
| PRKG2protein kinase cGMP-dependent 2 | Often (30–79%) | In 1 condition |
| PRR12proline rich 12 | Often (30–79%) | In 1 condition |
| PSMC3proteasome 26S subunit, ATPase 3 | Often (30–79%) | In 1 condition |
| PSMD12proteasome 26S subunit, non-ATPase 12 | Often (30–79%) | In 1 condition |
| RPS23ribosomal protein S23 | Often (30–79%) | In 1 condition |
| RUSC2RUN and SH3 domain containing 2 | Often (30–79%) | In 1 condition |
| SETBP1SET binding protein 1 | Often (30–79%) | In 1 condition |
| SETD5SET domain containing 5 | Often (30–79%) | In 1 condition |
| SOX10SRY-box transcription factor 10 | Often (30–79%) | In 2 conditions |
| SPOPspeckle type BTB/POZ protein | Often (30–79%) | In 1 condition |
| TAF1TATA-box binding protein associated factor 1 | Often (30–79%) | In 2 conditions |
| TFE3transcription factor binding to IGHM enhancer 3 | Often (30–79%) | In 1 condition |
| TMEM147transmembrane protein 147 | Often (30–79%) | In 1 condition |
| TRIM8tripartite motif containing 8 | Often (30–79%) | In 1 condition |
| TRIOtrio Rho guanine nucleotide exchange factor | Often (30–79%) | In 2 conditions |
| TRMT1tRNA methyltransferase 1 | Often (30–79%) | In 1 condition |
| VPS33AVPS33A core subunit of CORVET and HOPS complexes | Often (30–79%) | In 1 condition |
| WARS1tryptophanyl-tRNA synthetase 1 | Often (30–79%) | In 1 condition |
| WDR83OSWD repeat domain 83 opposite strand | Often (30–79%) | In 1 condition |
| XYLT1xylosyltransferase 1 | Often (30–79%) | In 2 conditions |
| ZBTB20zinc finger and BTB domain containing 20 | Often (30–79%) | In 2 conditions |
| ZFXzinc finger protein X-linked | Often (30–79%) | In 1 condition |
| ABCA5ATP binding cassette subfamily A member 5 | Sometimes (5–29%) | In 1 condition |
| ADAT3adenosine deaminase tRNA specific 3 | Sometimes (5–29%) | In 1 condition |
| ASXL3ASXL transcriptional regulator 3 | Sometimes (5–29%) | In 2 conditions |
| CDC42cell division cycle 42 | Sometimes (5–29%) | In 2 conditions |
| CDC42BPBCDC42 binding protein kinase beta | Sometimes (5–29%) | In 1 condition |
| CDH2cadherin 2 | Sometimes (5–29%) | In 1 condition |
| CDK10cyclin dependent kinase 10 | Sometimes (5–29%) | In 1 condition |
| CDKL5cyclin dependent kinase like 5 | Sometimes (5–29%) | In 1 condition |
| CHD5chromodomain helicase DNA binding protein 5 | Sometimes (5–29%) | In 1 condition |
| CHMP1Acharged multivesicular body protein 1A | Sometimes (5–29%) | In 1 condition |
| CHRNA7cholinergic receptor nicotinic alpha 7 subunit | Sometimes (5–29%) | In 1 condition |
| CLCN3Cl-/H+ antiporter 3 | Sometimes (5–29%) | In 1 condition |
| CSNK2A1casein kinase 2 alpha 1 | Sometimes (5–29%) | In 1 condition |
| CTCFCCCTC-binding factor | Sometimes (5–29%) | In 1 condition |
| DDB1damage specific DNA binding protein 1 | Sometimes (5–29%) | In 1 condition |
| DHX30DExH-box helicase 30 | Sometimes (5–29%) | In 1 condition |
| DOT1LDOT1 like histone lysine methyltransferase | Sometimes (5–29%) | In 1 condition |
| EBF3EBF transcription factor 3 | Sometimes (5–29%) | In 1 condition |
| EMILIN1elastin microfibril interfacer 1 | Sometimes (5–29%) | In 1 condition |
| ERLIN2ER lipid raft associated 2 | Sometimes (5–29%) | In 2 conditions |
| FBXL4F-box and leucine rich repeat protein 4 | Sometimes (5–29%) | In 1 condition |
| FEM1Bfem-1 homolog B | Sometimes (5–29%) | In 1 condition |
| FGF3fibroblast growth factor 3 | Sometimes (5–29%) | In 1 condition |
| GABRA3gamma-aminobutyric acid type A receptor subunit alpha3 | Sometimes (5–29%) | In 1 condition |
| GNB2G protein subunit beta 2 | Sometimes (5–29%) | In 1 condition |
| HECTD4HECT domain E3 ubiquitin protein ligase 4 | Sometimes (5–29%) | In 1 condition |
| HGSNATheparan-alpha-glucosaminide N-acetyltransferase | Sometimes (5–29%) | In 1 condition |
| HIVEP2HIVEP zinc finger 2 | Sometimes (5–29%) | In 1 condition |
| HMGA2high mobility group AT-hook 2 | Sometimes (5–29%) | In 1 condition |
| HNRNPUheterogeneous nuclear ribonucleoprotein U | Sometimes (5–29%) | In 1 condition |
| JARID2jumonji and AT-rich interaction domain containing 2 | Sometimes (5–29%) | In 1 condition |
| KCNMA1potassium calcium-activated channel subfamily M alpha 1 | Sometimes (5–29%) | In 1 condition |
| KDM1Alysine demethylase 1A | Sometimes (5–29%) | In 2 conditions |
| KDM2Blysine demethylase 2B | Sometimes (5–29%) | In 1 condition |
| KDM4Blysine demethylase 4B | Sometimes (5–29%) | In 1 condition |
| KICS2KICSTOR subunit 2 | Sometimes (5–29%) | In 1 condition |
| KIF26Akinesin family member 26A | Sometimes (5–29%) | In 1 condition |
| KITKIT proto-oncogene, receptor tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| KLF13KLF transcription factor 13 | Sometimes (5–29%) | In 1 condition |
| LEMD3LEM domain containing 3 | Sometimes (5–29%) | In 1 condition |
| MAPRE2microtubule associated protein RP/EB family member 2 | Sometimes (5–29%) | In 1 condition |
| MED16mediator complex subunit 16 | Sometimes (5–29%) | In 1 condition |
| MED27mediator complex subunit 27 | Sometimes (5–29%) | In 1 condition |
| NDST1N-deacetylase and N-sulfotransferase 1 | Sometimes (5–29%) | In 1 condition |
| NKX6-2NK6 homeobox 2 | Sometimes (5–29%) | In 1 condition |
| NOTCH2notch receptor 2 | Sometimes (5–29%) | In 2 conditions |
| PACS1phosphofurin acidic cluster sorting protein 1 | Sometimes (5–29%) | In 2 conditions |
| PCDHGC4protocadherin gamma subfamily C, 4 | Sometimes (5–29%) | In 1 condition |
| PHF8PHD finger protein 8 | Sometimes (5–29%) | In 2 conditions |
| PIGNphosphatidylinositol glycan anchor biosynthesis class N | Sometimes (5–29%) | In 1 condition |
| PLOD1procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 | Sometimes (5–29%) | In 1 condition |
| PPP1R15Bprotein phosphatase 1 regulatory subunit 15B | Sometimes (5–29%) | In 1 condition |
| PTBP1polypyrimidine tract binding protein 1 | Sometimes (5–29%) | In 1 condition |
| PTCH1patched 1 | Sometimes (5–29%) | In 1 condition |
| RAB34RAB34, member RAS oncogene family | Sometimes (5–29%) | In 1 condition |
| RAC1Rac family small GTPase 1 | Sometimes (5–29%) | In 1 condition |
| SCN4Asodium voltage-gated channel alpha subunit 4 | Sometimes (5–29%) | In 2 conditions |
| SLC1A4solute carrier family 1 member 4 | Sometimes (5–29%) | In 1 condition |
| SLC32A1solute carrier family 32 member 1 | Sometimes (5–29%) | In 1 condition |
| SLC4A10solute carrier family 4 member 10 | Sometimes (5–29%) | In 1 condition |
| SMARCA2SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 | Sometimes (5–29%) | In 1 condition |
| SMCHD1structural maintenance of chromosomes flexible hinge domain containing 1 | Sometimes (5–29%) | In 1 condition |
| SNAI2snail family transcriptional repressor 2 | Sometimes (5–29%) | In 1 condition |
| SPENspen family transcriptional repressor | Sometimes (5–29%) | In 1 condition |
| STAG1STAG1 cohesin complex component | Sometimes (5–29%) | In 1 condition |
| TBCDtubulin folding cofactor D | Sometimes (5–29%) | In 1 condition |
| TBCKTBC1 domain containing kinase | Sometimes (5–29%) | In 2 conditions |
| TOE1target of EGR1, exonuclease | Sometimes (5–29%) | In 1 condition |
| TRMT10AtRNA methyltransferase 10A | Sometimes (5–29%) | In 1 condition |
| TTI2TELO2 interacting protein 2 | Sometimes (5–29%) | In 2 conditions |
| TUBGCP2tubulin gamma complex component 2 | Sometimes (5–29%) | In 1 condition |
| UFC1ubiquitin-fold modifier conjugating enzyme 1 | Sometimes (5–29%) | In 1 condition |
| UGDHUDP-glucose 6-dehydrogenase | Sometimes (5–29%) | In 1 condition |
| UGP2UDP-glucose pyrophosphorylase 2 | Sometimes (5–29%) | In 1 condition |
| WACWW domain containing adaptor with coiled-coil | Sometimes (5–29%) | In 3 conditions |
| WNT4Wnt family member 4 | Sometimes (5–29%) | In 1 condition |
| ZIC2Zic family zinc finger 2 | Sometimes (5–29%) | In 1 condition |
| ZMYND11zinc finger MYND-type containing 11 | Sometimes (5–29%) | In 1 condition |
| ZNF292zinc finger protein 292 | Sometimes (5–29%) | In 1 condition |
| ZNF699zinc finger protein 699 | Sometimes (5–29%) | In 1 condition |
| ZNF711ZFX family zinc finger ZNF711 | Sometimes (5–29%) | In 1 condition |
| CNTNAP2contactin associated protein 2 | Rarely (1–4%) | In 1 condition |
| GJA5gap junction protein alpha 5 | Rarely (1–4%) | In 1 condition |
| GJA8gap junction protein alpha 8 | Rarely (1–4%) | In 1 condition |
| MARK2microtubule affinity regulating kinase 2 | Rarely (1–4%) | In 1 condition |
| SPTBN1spectrin beta, non-erythrocytic 1 | Rarely (1–4%) | In 1 condition |
| ARL3ARF like GTPase 3 | Not recorded | In 1 condition |
| ARXaristaless related homeobox | Not recorded | In 1 condition |
| CDONcell adhesion associated, oncogene regulated | Not recorded | In 1 condition |
| CHSY1chondroitin sulfate synthase 1 | Not recorded | In 1 condition |
| GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | Not recorded | In 1 condition |
| IGF1Rinsulin like growth factor 1 receptor | Not recorded | In 1 condition |
| KCNH1potassium voltage-gated channel subfamily H member 1 | Not recorded | In 1 condition |
| KIFBPkinesin family binding protein | Not recorded | In 1 condition |
| MED13mediator complex subunit 13 | Not recorded | In 1 condition |
| NAGLUN-acetyl-alpha-glucosaminidase | Not recorded | In 1 condition |
| NANSN-acetylneuraminate synthase | Not recorded | In 1 condition |
| NFIXnuclear factor I X | Not recorded | In 1 condition |
| NSUN2NOP2/Sun RNA methyltransferase 2 | Not recorded | In 1 condition |
| SGSHN-sulfoglucosamine sulfohydrolase | Not recorded | In 1 condition |
| SLC25A24solute carrier family 25 member 24 | Not recorded | In 1 condition |
| TALDO1transaldolase 1 | Not recorded | In 1 condition |
| TRAPPC10trafficking protein particle complex subunit 10 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
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