Trait
Large forehead
Summary
- Also called
- Increased size of forehead, Increased size of frontal region of face
- Body system
- Abnormality of head or neck
Reference genomeGRCh38hg38
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Get my Genome Test26 genes linked to Large forehead
Changes in these genes cause rare conditions in which Large forehead is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| HS6ST2heparan sulfate 6-O-sulfotransferase 2 | Always | In 1 condition |
| STRADASTE20 related adaptor alpha | Always | In 1 condition |
| LMX1BLIM homeobox transcription factor 1 beta | Very often (80–99%) | In 1 condition |
| STXBP1syntaxin binding protein 1 | Very often (80–99%) | In 1 condition |
| AMMECR1AMMECR nuclear protein 1 | Often (30–79%) | In 1 condition |
| BMPR1Abone morphogenetic protein receptor type 1A | Often (30–79%) | In 1 condition |
| FMR1fragile X messenger ribonucleoprotein 1 | Often (30–79%) | In 2 conditions |
| LEMD2LEM domain nuclear envelope protein 2 | Often (30–79%) | In 1 condition |
| ODC1ornithine decarboxylase 1 | Often (30–79%) | In 1 condition |
| PTENphosphatase and tensin homolog | Often (30–79%) | In 1 condition |
| RNF125ring finger protein 125 | Often (30–79%) | In 1 condition |
| SPOPspeckle type BTB/POZ protein | Often (30–79%) | In 1 condition |
| TMLHEtrimethyllysine hydroxylase, epsilon | Often (30–79%) | In 1 condition |
| VPS33AVPS33A core subunit of CORVET and HOPS complexes | Often (30–79%) | In 1 condition |
| CAMTA1calmodulin binding transcription activator 1 | Sometimes (5–29%) | In 2 conditions |
| GNB2G protein subunit beta 2 | Sometimes (5–29%) | In 1 condition |
| PDE4Dphosphodiesterase 4D | Sometimes (5–29%) | In 1 condition |
| TAOK1TAO kinase 1 | Sometimes (5–29%) | In 1 condition |
| TOE1target of EGR1, exonuclease | Sometimes (5–29%) | In 1 condition |
| UNC45Aunc-45 myosin chaperone A | Sometimes (5–29%) | In 1 condition |
| POU4F1POU class 4 homeobox 1 | Rarely (1–4%) | In 1 condition |
| ARID2AT-rich interaction domain 2 | Not recorded | In 1 condition |
| FLNAfilamin A | Not recorded | In 1 condition |
| MEIS2Meis homeobox 2 | Not recorded | In 1 condition |
| SRCSRC proto-oncogene, non-receptor tyrosine kinase | Not recorded | In 1 condition |
| SUMF1sulfatase modifying factor 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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