Trait
Ankle flexion contracture
Summary
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Ankle flexion contracture, and the rest of your genome, with one test.
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Get my Genome Test57 genes linked to Ankle flexion contracture
Changes in these genes cause rare conditions in which Ankle flexion contracture is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| C18orf32chromosome 18 open reading frame 32 | Always | In 1 condition |
| DAG1dystroglycan 1 | Always | In 2 conditions |
| FKBP10FKBP prolyl isomerase 10 | Always | In 1 condition |
| KLC4kinesin light chain 4 | Always | In 1 condition |
| LGI4leucine rich repeat LGI family member 4 | Always | In 1 condition |
| NFATC2nuclear factor of activated T cells 2 | Always | In 1 condition |
| ORAI1ORAI calcium release-activated calcium modulator 1 | Always | In 1 condition |
| SGCAsarcoglycan alpha | Always | In 1 condition |
| ADAMTS15ADAM metallopeptidase with thrombospondin type 1 motif 15 | Very often (80–99%) | In 1 condition |
| ERLIN2ER lipid raft associated 2 | Very often (80–99%) | In 2 conditions |
| KLHL9kelch like family member 9 | Very often (80–99%) | In 1 condition |
| NT5C25'-nucleotidase, cytosolic II | Very often (80–99%) | In 1 condition |
| ATP5F1DATP synthase F1 subunit delta | Often (30–79%) | In 1 condition |
| CAPN3calpain 3 | Often (30–79%) | In 1 condition |
| COL12A1collagen type XII alpha 1 chain | Often (30–79%) | In 2 conditions |
| COL25A1collagen type XXV alpha 1 chain | Often (30–79%) | In 1 condition |
| COL6A1collagen type VI alpha 1 chain | Often (30–79%) | In 1 condition |
| COL6A2collagen type VI alpha 2 chain | Often (30–79%) | In 1 condition |
| COL6A3collagen type VI alpha 3 chain | Often (30–79%) | In 1 condition |
| ERGIC1endoplasmic reticulum-golgi intermediate compartment 1 | Often (30–79%) | In 1 condition |
| NEBnebulin | Often (30–79%) | In 1 condition |
| PI4KAphosphatidylinositol 4-kinase alpha | Often (30–79%) | In 1 condition |
| RPL10ribosomal protein L10 | Often (30–79%) | In 1 condition |
| RYR1ryanodine receptor 1 | Often (30–79%) | In 1 condition |
| SCYL2SCY1 like pseudokinase 2 | Often (30–79%) | In 1 condition |
| SLC1A4solute carrier family 1 member 4 | Often (30–79%) | In 1 condition |
| SPG11SPG11 vesicle trafficking associated, spatacsin | Often (30–79%) | In 1 condition |
| SPTBN4spectrin beta, non-erythrocytic 4 | Often (30–79%) | In 1 condition |
| SVILsupervillin | Often (30–79%) | In 1 condition |
| TOR1AIP1torsin 1A interacting protein 1 | Often (30–79%) | In 1 condition |
| UBA1ubiquitin like modifier activating enzyme 1 | Often (30–79%) | In 1 condition |
| VARS1valyl-tRNA synthetase 1 | Often (30–79%) | In 1 condition |
| ACTA1actin alpha 1, skeletal muscle | Sometimes (5–29%) | In 1 condition |
| ALADaminolevulinate dehydratase | Sometimes (5–29%) | In 1 condition |
| ANO5anoctamin 5 | Sometimes (5–29%) | In 1 condition |
| COG8component of oligomeric golgi complex 8 | Sometimes (5–29%) | In 1 condition |
| DDR2discoidin domain receptor tyrosine kinase 2 | Sometimes (5–29%) | In 1 condition |
| DYRK1Adual specificity tyrosine phosphorylation regulated kinase 1A | Sometimes (5–29%) | In 1 condition |
| HACD13-hydroxyacyl-CoA dehydratase 1 | Sometimes (5–29%) | In 1 condition |
| ITGA7integrin subunit alpha 7 | Sometimes (5–29%) | In 1 condition |
Show 17 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| MAP3K20mitogen-activated protein kinase kinase kinase 20 | Sometimes (5–29%) | In 2 conditions |
| MYL2myosin light chain 2 | Sometimes (5–29%) | In 1 condition |
| PNPT1polyribonucleotide nucleotidyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| PSAT1phosphoserine aminotransferase 1 | Sometimes (5–29%) | In 1 condition |
| RTTNrotatin | Sometimes (5–29%) | In 1 condition |
| SELENONselenoprotein N | Sometimes (5–29%) | In 1 condition |
| SYT2synaptotagmin 2 | Sometimes (5–29%) | In 1 condition |
| TPM2tropomyosin 2 | Sometimes (5–29%) | In 1 condition |
| TPM3tropomyosin 3 | Sometimes (5–29%) | In 1 condition |
| APC2APC regulator of Wnt signaling pathway 2 | Rarely (1–4%) | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Rarely (1–4%) | In 1 condition |
| C19orf12chromosome 19 open reading frame 12 | Not recorded | In 1 condition |
| DPM1dolichyl-phosphate mannosyltransferase subunit 1, catalytic | Not recorded | In 1 condition |
| ESCO2establishment of sister chromatid cohesion N-acetyltransferase 2 | Not recorded | In 1 condition |
| FIG4FIG4 phosphoinositide 5-phosphatase | Not recorded | In 1 condition |
| FLNAfilamin A | Not recorded | In 1 condition |
| MMP2matrix metallopeptidase 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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