Trait
Abnormality of the ribs
Clinical name: Abnormal rib morphology
An anomaly of the rib.
Summary
- Also called
- Rib abnormalities, Rib anomalies
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Abnormality of the ribs, and the rest of your genome, with one test.
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Get my Genome Test94 genes linked to Abnormality of the ribs
Changes in these genes cause rare conditions in which Abnormality of the ribs is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CEP120centrosomal protein 120 | Very often (80–99%) | In 1 condition |
| CLCN7Cl-/H+ antiporter 7 | Very often (80–99%) | In 1 condition |
| COL11A1collagen type XI alpha 1 chain | Very often (80–99%) | In 1 condition |
| COL11A2collagen type XI alpha 2 chain | Very often (80–99%) | In 1 condition |
| CRTAPcartilage associated protein | Very often (80–99%) | In 1 condition |
| DLL3delta like canonical Notch ligand 3 | Very often (80–99%) | In 1 condition |
| DYNC2H1dynein cytoplasmic 2 heavy chain 1 | Very often (80–99%) | In 1 condition |
| DYNC2I1dynein 2 intermediate chain 1 | Very often (80–99%) | In 1 condition |
| DYNC2I2dynein 2 intermediate chain 2 | Very often (80–99%) | In 1 condition |
| DYNC2LI1dynein cytoplasmic 2 light intermediate chain 1 | Very often (80–99%) | In 1 condition |
| GPC3glypican 3 | Very often (80–99%) | In 1 condition |
| GPC4glypican 4 | Very often (80–99%) | In 1 condition |
| GPX4glutathione peroxidase 4 | Very often (80–99%) | In 1 condition |
| HES7hes family bHLH transcription factor 7 | Very often (80–99%) | In 1 condition |
| IFT140intraflagellar transport 140 | Very often (80–99%) | In 1 condition |
| IFT172intraflagellar transport 172 | Very often (80–99%) | In 1 condition |
| IFT80intraflagellar transport 80 | Very often (80–99%) | In 1 condition |
| KIAA0753KIAA0753 | Very often (80–99%) | In 1 condition |
| LFNGLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | Very often (80–99%) | In 1 condition |
| LRP5LDL receptor related protein 5 | Very often (80–99%) | In 1 condition |
| MESP2mesoderm posterior bHLH transcription factor 2 | Very often (80–99%) | In 1 condition |
| OSTM1osteoclastogenesis associated transmembrane protein 1 | Very often (80–99%) | In 1 condition |
| P4HBprolyl 4-hydroxylase subunit beta | Very often (80–99%) | In 1 condition |
| PTCH1patched 1 | Very often (80–99%) | In 3 conditions |
| RIPPLY2ripply transcriptional repressor 2 | Very often (80–99%) | In 1 condition |
| SEC24DSEC24 homolog D, COPII component | Very often (80–99%) | In 1 condition |
| SLC26A2solute carrier family 26 member 2 | Very often (80–99%) | In 2 conditions |
| SMAD4SMAD family member 4 | Very often (80–99%) | In 1 condition |
| SNX10sorting nexin 10 | Very often (80–99%) | In 1 condition |
| SOSTsclerostin | Very often (80–99%) | In 1 condition |
| SP7Sp7 transcription factor | Very often (80–99%) | In 1 condition |
| TBX6T-box transcription factor 6 | Very often (80–99%) | In 2 conditions |
| TCIRG1T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 | Very often (80–99%) | In 1 condition |
| TNFSF11TNF superfamily member 11 | Very often (80–99%) | In 1 condition |
| TRPV4transient receptor potential cation channel subfamily V member 4 | Very often (80–99%) | In 1 condition |
| TTC21Btetratricopeptide repeat domain 21B | Very often (80–99%) | In 1 condition |
| WDR19WD repeat domain 19 | Very often (80–99%) | In 1 condition |
| CDC45cell division cycle 45 | Often (30–79%) | In 1 condition |
| CDC6cell division cycle 6 | Often (30–79%) | In 1 condition |
| CDONcell adhesion associated, oncogene regulated | Often (30–79%) | In 1 condition |
Show 54 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| CDT1chromatin licensing and DNA replication factor 1 | Often (30–79%) | In 1 condition |
| CHRM3cholinergic receptor muscarinic 3 | Often (30–79%) | In 1 condition |
| CRIPTOcripto, EGF-CFC family member | Often (30–79%) | In 1 condition |
| DISP1dispatched RND transporter family member 1 | Often (30–79%) | In 1 condition |
| DLL1delta like canonical Notch ligand 1 | Often (30–79%) | In 1 condition |
| ESCO2establishment of sister chromatid cohesion N-acetyltransferase 2 | Often (30–79%) | In 1 condition |
| FGF8fibroblast growth factor 8 | Often (30–79%) | In 1 condition |
| FLNAfilamin A | Often (30–79%) | In 2 conditions |
| FOXH1forkhead box H1 | Often (30–79%) | In 1 condition |
| GAS1growth arrest specific 1 | Often (30–79%) | In 1 condition |
| GDF3growth differentiation factor 3 | Often (30–79%) | In 1 condition |
| GDF6growth differentiation factor 6 | Often (30–79%) | In 2 conditions |
| GLE1GLE1 RNA export mediator | Often (30–79%) | In 1 condition |
| GLI2GLI family zinc finger 2 | Often (30–79%) | In 1 condition |
| GMNNgeminin DNA replication inhibitor | Often (30–79%) | In 1 condition |
| HNF1BHNF1 homeobox B | Often (30–79%) | In 1 condition |
| IDUAalpha-L-iduronidase | Often (30–79%) | In 1 condition |
| IRF6interferon regulatory factor 6 | Often (30–79%) | In 1 condition |
| MEOX1mesenchyme homeobox 1 | Often (30–79%) | In 1 condition |
| NODALnodal growth differentiation factor | Often (30–79%) | In 1 condition |
| ORC1origin recognition complex subunit 1 | Often (30–79%) | In 1 condition |
| ORC4origin recognition complex subunit 4 | Often (30–79%) | In 1 condition |
| ORC6origin recognition complex subunit 6 | Often (30–79%) | In 1 condition |
| PTCH2patched 2 | Often (30–79%) | In 1 condition |
| RSPO2R-spondin 2 | Often (30–79%) | In 1 condition |
| RUNX2RUNX family transcription factor 2 | Often (30–79%) | In 1 condition |
| SHHsonic hedgehog signaling molecule | Often (30–79%) | In 1 condition |
| SIX3SIX homeobox 3 | Often (30–79%) | In 1 condition |
| STILSTIL centriolar assembly protein | Often (30–79%) | In 1 condition |
| SUFUSUFU negative regulator of hedgehog signaling | Often (30–79%) | In 1 condition |
| TBX4T-box transcription factor 4 | Often (30–79%) | In 1 condition |
| TGIF1TGFB induced factor homeobox 1 | Often (30–79%) | In 1 condition |
| WNT3Wnt family member 3 | Often (30–79%) | In 1 condition |
| WNT4Wnt family member 4 | Often (30–79%) | In 1 condition |
| ZIC2Zic family zinc finger 2 | Often (30–79%) | In 1 condition |
| APCAPC regulator of Wnt signaling pathway | Sometimes (5–29%) | In 1 condition |
| CHD7chromodomain helicase DNA binding protein 7 | Sometimes (5–29%) | In 2 conditions |
| DACT1dishevelled binding antagonist of beta catenin 1 | Sometimes (5–29%) | In 1 condition |
| DHCR77-dehydrocholesterol reductase | Sometimes (5–29%) | In 1 condition |
| FERMT1FERM domain containing kindlin 1 | Sometimes (5–29%) | In 1 condition |
| HOXD13homeobox D13 | Sometimes (5–29%) | In 1 condition |
| HSPG2heparan sulfate proteoglycan 2 | Sometimes (5–29%) | In 1 condition |
| LRP4LDL receptor related protein 4 | Sometimes (5–29%) | In 1 condition |
| OCRLOCRL inositol polyphosphate-5-phosphatase | Sometimes (5–29%) | In 1 condition |
| PORcytochrome p450 oxidoreductase | Sometimes (5–29%) | In 1 condition |
| PORCNporcupine O-acyltransferase | Sometimes (5–29%) | In 1 condition |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Sometimes (5–29%) | In 1 condition |
| SALL1spalt like transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| SEMA3Esemaphorin 3E | Sometimes (5–29%) | In 1 condition |
| TBX5T-box transcription factor 5 | Sometimes (5–29%) | In 1 condition |
| FRAS1Fraser extracellular matrix complex subunit 1 | Rarely (1–4%) | In 1 condition |
| FREM2FRAS1 related extracellular matrix 2 | Rarely (1–4%) | In 1 condition |
| GRIP1glutamate receptor interacting protein 1 | Rarely (1–4%) | In 1 condition |
| JAG1jagged canonical Notch ligand 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
- Thin ribs54 genes
- Rib fusion48 genes
- Broad ribs25 genes
- Cleft ribs18 genes
- Extra ribs18 genes
- Horizontal ribs17 genes
- Rib segmentation abnormalities13 genes
- Multiple rib fractures11 genes
- Flaring of rib cage8 genes
- Cupped ribs7 genes
- Thickened ribs7 genes
- Wavy ribs5 genes
- Abnormality of the costochondral junction4 genes
- Coat hanger sign of ribs4 genes
- Rib exostoses4 genes
- Absent/small ribs3 genes
- Fractured rib2 genes
- Rib spur2 genes
- Anomalous rib insertion to vertebrae1 gene
- Prominent floating ribs1 gene
- Rib gap1 gene
- Rib osteolysis1 gene
- Abnormal maturation of rib bones
- Calcification of ribs
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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