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Trait
Highly arched eyebrow
Increased height of the central portion of the eyebrow, forming a crescent, semicircular, or inverted U shape.
Summary
- Also called
- Arched eyebrows, Bowed and upward slanting eyebrows, Broad, arched eyebrows, High arched eyebrows, High, rounded eyebrows, High-arched eyebrows, Thick, flared eyebrows
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This page as data
Add .json to the page's address, or ask for application/json, to read it as JSON.
library(jsonlite)
url <- "https://dantelabs.com/traits/highly-arched-eyebrow.json"
page <- fromJSON(url)
page$trait$nameHighly arched eyebrowHP:0002553
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Get my Genome Test225 genes linked to Highly arched eyebrow
Changes in these genes cause rare conditions in which Highly arched eyebrow is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ACTG1actin gamma 1 | Always | In 2 conditions |
| BORCS8BLOC-1 related complex subunit 8 | Always | In 1 condition |
| CAMK2Gcalcium/calmodulin dependent protein kinase II gamma | Always | In 1 condition |
| CDC42cell division cycle 42 | Always | In 2 conditions |
| CEP295centrosomal protein 295 | Always | In 1 condition |
| CLP1cleavage factor polyribonucleotide kinase subunit 1 | Always | In 2 conditions |
| COLEC11collectin subfamily member 11 | Always | In 2 conditions |
| CREBBPCREB binding lysine acetyltransferase | Always | In 3 conditions |
| EP300EP300 lysine acetyltransferase | Always | In 3 conditions |
| ERI1exoribonuclease 1 | Always | In 1 condition |
| ESAMendothelial cell adhesion molecule | Always | In 1 condition |
| FLNAfilamin A | Always | In 1 condition |
| H4C11H4 clustered histone 11 | Always | In 1 condition |
| HDAC8histone deacetylase 8 | Always | In 2 conditions |
| HNRNPH1heterogeneous nuclear ribonucleoprotein H1 | Always | In 1 condition |
| JKAMPJNK1/MAPK8 associated membrane protein | Always | In 1 condition |
| KAT6Alysine acetyltransferase 6A | Always | In 1 condition |
| MASP1MBL associated serine protease 1 | Always | In 2 conditions |
| MEIS2Meis homeobox 2 | Always | In 1 condition |
| NAA80N-alpha-acetyltransferase 80, NatH catalytic subunit | Always | In 1 condition |
| NAV3neuron navigator 3 | Always | In 1 condition |
| NEUROG1neurogenin 1 | Always | In 1 condition |
| NUP188nucleoporin 188 | Always | In 1 condition |
| PGAP1post-GPI attachment to proteins inositol deacylase 1 | Always | In 1 condition |
| PIGSphosphatidylinositol glycan anchor biosynthesis class S | Always | In 1 condition |
| PPP2R3Cprotein phosphatase 2 regulatory subunit B''gamma | Always | In 1 condition |
| RAP1GDS1Rap1 GTPase-GDP dissociation stimulator 1 | Always | In 1 condition |
| RBSNrabenosyn, RAB effector | Always | In 1 condition |
| ROBO1roundabout guidance receptor 1 | Always | In 1 condition |
| SMAD4SMAD family member 4 | Always | In 1 condition |
| SMC1Astructural maintenance of chromosomes 1A | Always | In 3 conditions |
| SPOPspeckle type BTB/POZ protein | Always | In 1 condition |
| TAF4TATA-box binding protein associated factor 4 | Always | In 1 condition |
| TASP1taspase 1 | Always | In 1 condition |
| TCP1t-complex 1 | Always | In 1 condition |
| TMCO1transmembrane and coiled-coil domains 1 | Always | In 1 condition |
| TMEM94transmembrane protein 94 | Always | In 1 condition |
| TOP2BDNA topoisomerase II beta | Always | In 1 condition |
| VPS35LVPS35 endosomal protein sorting factor like | Always | In 1 condition |
| ZBTB18zinc finger and BTB domain containing 18 | Always | In 1 condition |
Show 185 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| ACTBactin beta | Very often (80–99%) | In 2 conditions |
| AFF4ALF transcription elongation factor 4 | Very often (80–99%) | In 1 condition |
| ASXL2ASXL transcriptional regulator 2 | Very often (80–99%) | In 1 condition |
| BCRBCR activator of RhoGEF and GTPase | Very often (80–99%) | In 1 condition |
| BRD4bromodomain containing 4 | Very often (80–99%) | In 2 conditions |
| CDH11cadherin 11 | Very often (80–99%) | In 1 condition |
| COLEC10collectin subfamily member 10 | Very often (80–99%) | In 2 conditions |
| CPLX1complexin 1 | Very often (80–99%) | In 3 conditions |
| CRKLCRK like proto-oncogene, adaptor protein | Very often (80–99%) | In 1 condition |
| CTBP1C-terminal binding protein 1 | Very often (80–99%) | In 2 conditions |
| EHMT1euchromatic histone lysine methyltransferase 1 | Very often (80–99%) | In 1 condition |
| KDM6Alysine demethylase 6A | Very often (80–99%) | In 3 conditions |
| KMT2Dlysine methyltransferase 2D | Very often (80–99%) | In 2 conditions |
| LETM1leucine zipper and EF-hand containing transmembrane protein 1 | Very often (80–99%) | In 2 conditions |
| MAPK1mitogen-activated protein kinase 1 | Very often (80–99%) | In 2 conditions |
| MAU2MAU2 sister chromatid cohesion factor | Very often (80–99%) | In 2 conditions |
| MDGA2MAM domain containing glycosylphosphatidylinositol anchor 2 | Very often (80–99%) | In 1 condition |
| NELFAnegative elongation factor complex member A | Very often (80–99%) | In 1 condition |
| NIPBLNIPBL cohesin loading factor | Very often (80–99%) | In 2 conditions |
| NSD2nuclear receptor binding SET domain protein 2 | Very often (80–99%) | In 3 conditions |
| PIGGphosphatidylinositol glycan anchor biosynthesis class G (EMM blood group) | Very often (80–99%) | In 1 condition |
| RAD21RAD21 cohesin complex component | Very often (80–99%) | In 2 conditions |
| SETD2SET domain containing 2, histone lysine methyltransferase | Very often (80–99%) | In 1 condition |
| SMC3structural maintenance of chromosomes 3 | Very often (80–99%) | In 2 conditions |
| SPECC1Lsperm antigen with calponin homology and coiled-coil domains 1 like | Very often (80–99%) | In 2 conditions |
| ASXL3ASXL transcriptional regulator 3 | Often (30–79%) | In 2 conditions |
| ATXN7L3ataxin 7 like 3 | Often (30–79%) | In 1 condition |
| AUTS2activator of transcription and developmental regulator AUTS2 | Often (30–79%) | In 2 conditions |
| CASKcalcium/calmodulin dependent serine protein kinase | Often (30–79%) | In 1 condition |
| CBLCbl proto-oncogene | Often (30–79%) | In 1 condition |
| CHST3carbohydrate sulfotransferase 3 | Often (30–79%) | In 2 conditions |
| CLCN6Cl-/H+ antiporter 6 | Often (30–79%) | In 1 condition |
| CSNK2A1casein kinase 2 alpha 1 | Often (30–79%) | In 1 condition |
| CYFIP2cytoplasmic FMR1 interacting protein 2 | Often (30–79%) | In 1 condition |
| DDX6DEAD-box helicase 6 | Often (30–79%) | In 1 condition |
| ESCO2establishment of sister chromatid cohesion N-acetyltransferase 2 | Often (30–79%) | In 2 conditions |
| FAR1fatty acyl-CoA reductase 1 | Often (30–79%) | In 2 conditions |
| FGFR1fibroblast growth factor receptor 1 | Often (30–79%) | In 1 condition |
| FGFRL1fibroblast growth factor receptor like 1 | Often (30–79%) | In 1 condition |
| FREM1FRAS1 related extracellular matrix 1 | Often (30–79%) | In 1 condition |
| FRMD4AFERM domain containing 4A | Often (30–79%) | In 1 condition |
| H4C9H4 clustered histone 9 | Often (30–79%) | In 1 condition |
| HDAC4histone deacetylase 4 | Often (30–79%) | In 2 conditions |
| KCNH1potassium voltage-gated channel subfamily H member 1 | Often (30–79%) | In 1 condition |
| KCNK9potassium two pore domain channel subfamily K member 9 | Often (30–79%) | In 2 conditions |
| KMT2Alysine methyltransferase 2A | Often (30–79%) | In 1 condition |
| LMX1BLIM homeobox transcription factor 1 beta | Often (30–79%) | In 1 condition |
| LTBP1latent transforming growth factor beta binding protein 1 | Often (30–79%) | In 1 condition |
| MAN2C1mannosidase alpha class 2C member 1 | Often (30–79%) | In 1 condition |
| MBD5methyl-CpG binding domain protein 5 | Often (30–79%) | In 2 conditions |
| MEGF8multiple EGF like domains 8 | Often (30–79%) | In 1 condition |
| MESDmesoderm development LRP chaperone | Often (30–79%) | In 1 condition |
| MKS1MKS transition zone complex subunit 1 | Often (30–79%) | In 3 conditions |
| MN1MN1 proto-oncogene, transcriptional regulator | Often (30–79%) | In 1 condition |
| NCAPG2non-SMC condensin II complex subunit G2 | Often (30–79%) | In 1 condition |
| NECTIN1nectin cell adhesion molecule 1 | Often (30–79%) | In 1 condition |
| NFIXnuclear factor I X | Often (30–79%) | In 1 condition |
| OTUD6BOTU deubiquitinase 6B | Often (30–79%) | In 2 conditions |
| PACS1phosphofurin acidic cluster sorting protein 1 | Often (30–79%) | In 2 conditions |
| PIGLphosphatidylinositol glycan anchor biosynthesis class L | Often (30–79%) | In 2 conditions |
| POGZpogo transposable element derived with ZNF domain | Often (30–79%) | In 1 condition |
| PRR12proline rich 12 | Often (30–79%) | In 1 condition |
| PTPRFprotein tyrosine phosphatase receptor type F | Often (30–79%) | In 1 condition |
| PUS7pseudouridine synthase 7 | Often (30–79%) | In 1 condition |
| RNF2ring finger protein 2 | Often (30–79%) | In 1 condition |
| RPS23ribosomal protein S23 | Often (30–79%) | In 1 condition |
| SHMT2serine hydroxymethyltransferase 2 | Often (30–79%) | In 1 condition |
| SMARCA2SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 | Often (30–79%) | In 2 conditions |
| SOX11SRY-box transcription factor 11 | Often (30–79%) | In 1 condition |
| STAG2STAG2 cohesin complex component | Often (30–79%) | In 1 condition |
| STXBP1syntaxin binding protein 1 | Often (30–79%) | In 1 condition |
| SV2Asynaptic vesicle glycoprotein 2A | Often (30–79%) | In 1 condition |
| TBCKTBC1 domain containing kinase | Often (30–79%) | In 1 condition |
| TGDSTDP-glucose 4,6-dehydratase | Often (30–79%) | In 1 condition |
| TWIST2twist family bHLH transcription factor 2 | Often (30–79%) | In 1 condition |
| WASHC4WASH complex subunit 4 | Often (30–79%) | In 1 condition |
| WDR83OSWD repeat domain 83 opposite strand | Often (30–79%) | In 1 condition |
| ZNF462zinc finger protein 462 | Often (30–79%) | In 2 conditions |
| ADAT3adenosine deaminase tRNA specific 3 | Sometimes (5–29%) | In 1 condition |
| AFG2AAAA ATPase AFG2A | Sometimes (5–29%) | In 1 condition |
| AHI1Abelson helper integration site 1 | Sometimes (5–29%) | In 3 conditions |
| ANKRD11ankyrin repeat domain 11 | Sometimes (5–29%) | In 1 condition |
| ARL13BARF like GTPase 13B | Sometimes (5–29%) | In 1 condition |
| ARL3ARF like GTPase 3 | Sometimes (5–29%) | In 2 conditions |
| ARMC9armadillo repeat containing 9 | Sometimes (5–29%) | In 1 condition |
| B9D1B9 domain containing 1 | Sometimes (5–29%) | In 1 condition |
| B9D2B9 domain containing 2 | Sometimes (5–29%) | In 1 condition |
| BCORBCL6 corepressor | Sometimes (5–29%) | In 1 condition |
| BICRABRD4 interacting chromatin remodeling complex associated protein | Sometimes (5–29%) | In 1 condition |
| CBY1chibby 1, beta catenin antagonist | Sometimes (5–29%) | In 1 condition |
| CC2D2Acoiled-coil and C2 domain containing 2A | Sometimes (5–29%) | In 2 conditions |
| CDC42BPBCDC42 binding protein kinase beta | Sometimes (5–29%) | In 1 condition |
| CDK13cyclin dependent kinase 13 | Sometimes (5–29%) | In 1 condition |
| CEP104centrosomal protein 104 | Sometimes (5–29%) | In 1 condition |
| CEP120centrosomal protein 120 | Sometimes (5–29%) | In 2 conditions |
| CEP290centrosomal protein 290 | Sometimes (5–29%) | In 1 condition |
| CEP41centrosomal protein 41 | Sometimes (5–29%) | In 2 conditions |
| CHD7chromodomain helicase DNA binding protein 7 | Sometimes (5–29%) | In 1 condition |
| CHD8chromodomain helicase DNA binding protein 8 | Sometimes (5–29%) | In 1 condition |
| COX7Bcytochrome c oxidase subunit 7B | Sometimes (5–29%) | In 1 condition |
| CPLANE1ciliogenesis and planar polarity effector complex subunit 1 | Sometimes (5–29%) | In 2 conditions |
| CSPP1centrosome and spindle pole associated protein 1 | Sometimes (5–29%) | In 1 condition |
| CTCFCCCTC-binding factor | Sometimes (5–29%) | In 2 conditions |
| ERMARDER membrane associated RNA degradation | Sometimes (5–29%) | In 1 condition |
| FAM149B1family with sequence similarity 149 member B1 | Sometimes (5–29%) | In 2 conditions |
| FAM20CFAM20C golgi associated secretory pathway kinase | Sometimes (5–29%) | In 1 condition |
| FBXO11F-box protein 11 | Sometimes (5–29%) | In 1 condition |
| FBXO31F-box protein 31 | Sometimes (5–29%) | In 1 condition |
| FOXL2forkhead box L2 | Sometimes (5–29%) | In 2 conditions |
| GAD1glutamate decarboxylase 1 | Sometimes (5–29%) | In 1 condition |
| HYLS1HYLS1 centriolar and ciliogenesis associated | Sometimes (5–29%) | In 1 condition |
| IFT74intraflagellar transport 74 | Sometimes (5–29%) | In 1 condition |
| INPP5Einositol polyphosphate-5-phosphatase E | Sometimes (5–29%) | In 4 conditions |
| KATNIPkatanin interacting protein | Sometimes (5–29%) | In 1 condition |
| KDM2Blysine demethylase 2B | Sometimes (5–29%) | In 1 condition |
| KIAA0586KIAA0586 | Sometimes (5–29%) | In 1 condition |
| KIAA0753KIAA0753 | Sometimes (5–29%) | In 2 conditions |
| KIF7kinesin family member 7 | Sometimes (5–29%) | In 1 condition |
| MADDMAP kinase activating death domain | Sometimes (5–29%) | In 1 condition |
| MAN1B1mannosidase alpha class 1B member 1 | Sometimes (5–29%) | In 1 condition |
| MAN2B1mannosidase alpha class 2B member 1 | Sometimes (5–29%) | In 1 condition |
| MED27mediator complex subunit 27 | Sometimes (5–29%) | In 1 condition |
| NPHP1nephrocystin 1 | Sometimes (5–29%) | In 1 condition |
| OFD1OFD1 centriole and centriolar satellite protein | Sometimes (5–29%) | In 2 conditions |
| PDE6Dphosphodiesterase 6D | Sometimes (5–29%) | In 2 conditions |
| PGAP2post-GPI attachment to proteins 2 | Sometimes (5–29%) | In 1 condition |
| PGAP3post-GPI attachment to proteins phospholipase 3 | Sometimes (5–29%) | In 1 condition |
| PIBF1progesterone immunomodulatory binding factor 1 | Sometimes (5–29%) | In 1 condition |
| PIGOphosphatidylinositol glycan anchor biosynthesis class O | Sometimes (5–29%) | In 1 condition |
| PIGVphosphatidylinositol glycan anchor biosynthesis class V | Sometimes (5–29%) | In 2 conditions |
| PIGWphosphatidylinositol glycan anchor biosynthesis class W | Sometimes (5–29%) | In 1 condition |
| PIGYphosphatidylinositol glycan anchor biosynthesis class Y | Sometimes (5–29%) | In 1 condition |
| PLAAphospholipase A2 activating protein | Sometimes (5–29%) | In 1 condition |
| PPP1CBprotein phosphatase 1 catalytic subunit beta | Sometimes (5–29%) | In 1 condition |
| PUF60poly(U) binding splicing factor 60 | Sometimes (5–29%) | In 1 condition |
| RAC1Rac family small GTPase 1 | Sometimes (5–29%) | In 2 conditions |
| RHOBTB2Rho related BTB domain containing 2 | Sometimes (5–29%) | In 1 condition |
| RPGRIP1LRPGRIP1 like | Sometimes (5–29%) | In 2 conditions |
| SEMA3Esemaphorin 3E | Sometimes (5–29%) | In 1 condition |
| SEPHS1selenophosphate synthetase 1 | Sometimes (5–29%) | In 1 condition |
| SGSM3small G protein signaling modulator 3 | Sometimes (5–29%) | In 1 condition |
| SMPD4sphingomyelin phosphodiesterase 4 | Sometimes (5–29%) | In 1 condition |
| SPENspen family transcriptional repressor | Sometimes (5–29%) | In 1 condition |
| STRADASTE20 related adaptor alpha | Sometimes (5–29%) | In 1 condition |
| SUFUSUFU negative regulator of hedgehog signaling | Sometimes (5–29%) | In 1 condition |
| SUPT16HSPT16 homolog, facilitates chromatin remodeling subunit | Sometimes (5–29%) | In 1 condition |
| TAF6TATA-box binding protein associated factor 6 | Sometimes (5–29%) | In 1 condition |
| TBX4T-box transcription factor 4 | Sometimes (5–29%) | In 1 condition |
| TCTN1tectonic family member 1 | Sometimes (5–29%) | In 1 condition |
| TCTN2tectonic family member 2 | Sometimes (5–29%) | In 1 condition |
| TCTN3tectonic family member 3 | Sometimes (5–29%) | In 2 conditions |
| TMEM138transmembrane protein 138 | Sometimes (5–29%) | In 1 condition |
| TMEM216transmembrane protein 216 | Sometimes (5–29%) | In 2 conditions |
| TMEM218transmembrane protein 218 | Sometimes (5–29%) | In 1 condition |
| TMEM231transmembrane protein 231 | Sometimes (5–29%) | In 2 conditions |
| TMEM237transmembrane protein 237 | Sometimes (5–29%) | In 4 conditions |
| TMEM67transmembrane protein 67 | Sometimes (5–29%) | In 2 conditions |
| TOGARAM1TOG array regulator of axonemal microtubules 1 | Sometimes (5–29%) | In 1 condition |
| TOPORSTOP1 binding arginine/serine rich protein, E3 ubiquitin ligase | Sometimes (5–29%) | In 1 condition |
| TRIOtrio Rho guanine nucleotide exchange factor | Sometimes (5–29%) | In 1 condition |
| TTC5tetratricopeptide repeat domain 5 | Sometimes (5–29%) | In 1 condition |
| UGP2UDP-glucose pyrophosphorylase 2 | Sometimes (5–29%) | In 1 condition |
| ZFXzinc finger protein X-linked | Sometimes (5–29%) | In 1 condition |
| ZNF423zinc finger protein 423 | Sometimes (5–29%) | In 1 condition |
| ACBD6acyl-CoA binding domain containing 6 | Rarely (1–4%) | In 1 condition |
| GJA5gap junction protein alpha 5 | Rarely (1–4%) | In 1 condition |
| GJA8gap junction protein alpha 8 | Rarely (1–4%) | In 1 condition |
| ZEB2zinc finger E-box binding homeobox 2 | Rarely (1–4%) | In 1 condition |
| ASPMassembly factor for spindle microtubules | Not recorded | In 1 condition |
| C12orf57chromosome 12 open reading frame 57 | Not recorded | In 1 condition |
| CHSY1chondroitin sulfate synthase 1 | Not recorded | In 1 condition |
| CTU2cytosolic thiouridylase subunit 2 | Not recorded | In 1 condition |
| ECEL1endothelin converting enzyme like 1 | Not recorded | In 1 condition |
| HSPA9heat shock protein family A (Hsp70) member 9 | Not recorded | In 1 condition |
| IGF1Rinsulin like growth factor 1 receptor | Not recorded | In 1 condition |
| KDM1Alysine demethylase 1A | Not recorded | In 1 condition |
| KIFBPkinesin family binding protein | Not recorded | In 1 condition |
| LRPPRCleucine rich pentatricopeptide repeat containing | Not recorded | In 1 condition |
| RPS6KA3ribosomal protein S6 kinase A3 | Not recorded | In 1 condition |
| RUSC2RUN and SH3 domain containing 2 | Not recorded | In 1 condition |
| SLC45A1solute carrier family 45 member 1 | Not recorded | In 1 condition |
| SZT2SZT2 subunit of KICSTOR complex | Not recorded | In 1 condition |
| TFAP2Btranscription factor AP-2 beta | Not recorded | In 1 condition |
| TRRAPtransformation/transcription domain associated protein | Not recorded | In 1 condition |
| ZSWIM6zinc finger SWIM-type containing 6 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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