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Trait

Pulmonic regurgitation

The retrograde (backwards) flow of blood through the pulmonary valve into the right ventricle during diastole.

HPO HP:0010444

Summary

Also called
Pulmonary incompetence, Pulmonary valve insufficiency, Pulmonary valve regurgitation, Puolmonary valve insufficiency
Body system
Abnormality of the cardiovascular system

29 genes linked to Pulmonic regurgitation

Changes in these genes cause rare conditions in which Pulmonic regurgitation is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
FLNAfilamin AAlwaysIn 2 conditions
NEXNnexilin F-actin binding proteinAlwaysIn 1 condition
ADAadenosine deaminaseOften (30–79%)In 1 condition
ADAMTS19ADAM metallopeptidase with thrombospondin type 1 motif 19Often (30–79%)In 1 condition
GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and betaOften (30–79%)In 1 condition
KIF20Akinesin family member 20AOften (30–79%)In 1 condition
LEMD2LEM domain nuclear envelope protein 2Often (30–79%)In 1 condition
ABCA3ATP binding cassette subfamily A member 3Sometimes (5–29%)In 1 condition
ARSBarylsulfatase BSometimes (5–29%)In 1 condition
ATP11AATPase phospholipid transporting 11ASometimes (5–29%)In 1 condition
CIROZciliated left-right organizer protein containing ZP-N domainsSometimes (5–29%)In 1 condition
COL1A2collagen type I alpha 2 chainSometimes (5–29%)In 2 conditions
DPP9dipeptidyl peptidase 9Sometimes (5–29%)In 1 condition
DSPdesmoplakinSometimes (5–29%)In 1 condition
FAM13Afamily with sequence similarity 13 member ASometimes (5–29%)In 1 condition
MUC5Bmucin 5B, oligomeric mucus/gel-formingSometimes (5–29%)In 1 condition
PARNpoly(A)-specific ribonucleaseSometimes (5–29%)In 1 condition
RTEL1regulator of telomere elongation helicase 1Sometimes (5–29%)In 1 condition
SFTPA1surfactant protein A1Sometimes (5–29%)In 1 condition
SFTPA2surfactant protein A2Sometimes (5–29%)In 1 condition
SFTPCsurfactant protein CSometimes (5–29%)In 1 condition
STN1STN1 subunit of CST complexSometimes (5–29%)In 1 condition
TERCtelomerase RNA componentSometimes (5–29%)In 1 condition
TERTtelomerase reverse transcriptaseSometimes (5–29%)In 1 condition
COL1A1collagen type I alpha 1 chainNot recordedIn 1 condition
DNAL1dynein axonemal light chain 1Not recordedIn 1 condition
EFEMP2EGF-like fibulin extracellular matrix protein 2Not recordedIn 1 condition
FOXF1forkhead box F1Not recordedIn 1 condition
INVSinversinNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal pulmonary valve physiology

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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