Trait
Large platelets
Clinical name: Increased mean platelet volume
Average platelet volume above the upper limit of the normal reference interval.
Summary
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test20 genes linked to Large platelets
Changes in these genes cause rare conditions in which Large platelets is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ACTBactin beta | Always | In 1 condition |
| ACTN1actinin alpha 1 | Always | In 2 conditions |
| CDC42cell division cycle 42 | Always | In 2 conditions |
| FLI1Fli-1 proto-oncogene, ETS transcription factor | Always | In 1 condition |
| GATA1GATA binding protein 1 | Always | In 1 condition |
| GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | Always | In 1 condition |
| GP1BAglycoprotein Ib platelet subunit alpha | Always | In 2 conditions |
| ITGB3integrin subunit beta 3 | Always | In 2 conditions |
| TPM4tropomyosin 4 | Always | In 2 conditions |
| DIAPH1diaphanous related formin 1 | Very often (80–99%) | In 1 condition |
| GFI1Bgrowth factor independent 1B transcriptional repressor | Very often (80–99%) | In 1 condition |
| GP1BBglycoprotein Ib platelet subunit beta | Very often (80–99%) | In 1 condition |
| ITGA2Bintegrin subunit alpha 2b | Very often (80–99%) | In 1 condition |
| TRPM7transient receptor potential cation channel subfamily M member 7 | Very often (80–99%) | In 1 condition |
| TUBA8tubulin alpha 8 | Very often (80–99%) | In 1 condition |
| TUBB1tubulin beta 1 class VI | Very often (80–99%) | In 1 condition |
| MYH9myosin heavy chain 9 | Often (30–79%) | In 1 condition |
| SKIC3SKI3 subunit of superkiller complex | Often (30–79%) | In 2 conditions |
| SKIC2SKI2 subunit of superkiller complex | Sometimes (5–29%) | In 1 condition |
| FLNAfilamin A | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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