Skip to content
Use your HSA or FSA funds

Trait

Absent calf bone

Clinical name: Fibular aplasia

Absence of the fibula.

HPO HP:0002990

Summary

Also called
Absent fibulae, Absent-hypoplastic fibulae
Body system
Abnormality of limbsAbnormality of the musculoskeletal system

10 genes linked to Absent calf bone

Changes in these genes cause rare conditions in which Absent calf bone is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
BMPR1Bbone morphogenetic protein receptor type 1BAlwaysIn 1 condition
FLNBfilamin BAlwaysIn 3 conditions
GDF5growth differentiation factor 5Very often (80–99%)In 1 condition
LMBR1limb development membrane protein 1Very often (80–99%)In 2 conditions
WNT7AWnt family member 7AVery often (80–99%)In 3 conditions
FLNAfilamin AOften (30–79%)In 1 condition
CPLANE1ciliogenesis and planar polarity effector complex subunit 1Sometimes (5–29%)In 1 condition
RBM8ARNA binding motif protein 8ASometimes (5–29%)In 2 conditions
AMER1APC membrane recruitment protein 1Not recordedIn 1 condition
TBX15T-box transcription factor 15Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Absent/small calf bone

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test