Trait
Inability to straighten knee
Clinical name: Knee flexion contracture
A type of knee joint contracture in which the knee is in a fixed bent (flexed) configuration such that it cannot be straightened actively or passively.
Summary
- Also called
- Flexion contracture of knees, Flexion contractures at both knees, Flexion contractures of knees, Flexion deformity of the knee, Knee flexion contractures, Knee flexion deformity
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Inability to straighten knee, and the rest of your genome, with one test.
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Get my Genome Test109 genes linked to Inability to straighten knee
Changes in these genes cause rare conditions in which Inability to straighten knee is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CHRNB1cholinergic receptor nicotinic beta 1 subunit | Always | In 1 condition |
| CHRNGcholinergic receptor nicotinic gamma subunit | Always | In 1 condition |
| DMDdystrophin | Always | In 1 condition |
| DONSONDNA replication fork stabilization factor DONSON | Always | In 1 condition |
| EMDemerin | Always | In 1 condition |
| ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit | Always | In 1 condition |
| FBN2fibrillin 2 | Always | In 1 condition |
| FKBP10FKBP prolyl isomerase 10 | Always | In 1 condition |
| GNB2G protein subunit beta 2 | Always | In 1 condition |
| GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta | Always | In 2 conditions |
| KLC4kinesin light chain 4 | Always | In 1 condition |
| LBRlamin B receptor | Always | In 1 condition |
| LGI4leucine rich repeat LGI family member 4 | Always | In 1 condition |
| MAU2MAU2 sister chromatid cohesion factor | Always | In 1 condition |
| MYO9Amyosin IXA | Always | In 1 condition |
| NFATC2nuclear factor of activated T cells 2 | Always | In 1 condition |
| PSTPIP1proline-serine-threonine phosphatase interacting protein 1 | Always | In 1 condition |
| SIK3SIK family kinase 3 | Always | In 1 condition |
| SNAP25synaptosome associated protein 25 | Always | In 1 condition |
| SRD5A3steroid 5 alpha-reductase 3 | Always | In 1 condition |
| TAF4TATA-box binding protein associated factor 4 | Always | In 1 condition |
| ADAMTS15ADAM metallopeptidase with thrombospondin type 1 motif 15 | Very often (80–99%) | In 1 condition |
| ERLIN2ER lipid raft associated 2 | Very often (80–99%) | In 2 conditions |
| FBN1fibrillin 1 | Very often (80–99%) | In 1 condition |
| KAT6Blysine acetyltransferase 6B | Very often (80–99%) | In 2 conditions |
| NT5C25'-nucleotidase, cytosolic II | Very often (80–99%) | In 1 condition |
| ALG2ALG2 alpha-1,3/1,6-mannosyltransferase | Often (30–79%) | In 2 conditions |
| ANKLE2ankyrin repeat and LEM domain containing 2 | Often (30–79%) | In 1 condition |
| COL12A1collagen type XII alpha 1 chain | Often (30–79%) | In 2 conditions |
| COL25A1collagen type XXV alpha 1 chain | Often (30–79%) | In 1 condition |
| COL6A1collagen type VI alpha 1 chain | Often (30–79%) | In 1 condition |
| COL6A2collagen type VI alpha 2 chain | Often (30–79%) | In 1 condition |
| COL6A3collagen type VI alpha 3 chain | Often (30–79%) | In 1 condition |
| ERGIC1endoplasmic reticulum-golgi intermediate compartment 1 | Often (30–79%) | In 1 condition |
| FDFT1farnesyl-diphosphate farnesyltransferase 1 | Often (30–79%) | In 1 condition |
| GLI3GLI family zinc finger 3 | Often (30–79%) | In 1 condition |
| HS2ST1heparan sulfate 2-O-sulfotransferase 1 | Often (30–79%) | In 1 condition |
| LIFRLIF receptor subunit alpha | Often (30–79%) | In 2 conditions |
| MYH3myosin heavy chain 3 | Often (30–79%) | In 2 conditions |
| MYL1myosin light chain 1 | Often (30–79%) | In 1 condition |
Show 69 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| MYL11myosin light chain 11 | Often (30–79%) | In 1 condition |
| NALCNsodium leak channel, non-selective | Often (30–79%) | In 1 condition |
| PI4KAphosphatidylinositol 4-kinase alpha | Often (30–79%) | In 3 conditions |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Often (30–79%) | In 1 condition |
| PIGYphosphatidylinositol glycan anchor biosynthesis class Y | Often (30–79%) | In 1 condition |
| RPL10ribosomal protein L10 | Often (30–79%) | In 1 condition |
| SCYL2SCY1 like pseudokinase 2 | Often (30–79%) | In 1 condition |
| SLC18A3solute carrier family 18 member A3 | Often (30–79%) | In 1 condition |
| SVILsupervillin | Often (30–79%) | In 1 condition |
| SYT2synaptotagmin 2 | Often (30–79%) | In 1 condition |
| UBA1ubiquitin like modifier activating enzyme 1 | Often (30–79%) | In 1 condition |
| ACTA1actin alpha 1, skeletal muscle | Sometimes (5–29%) | In 1 condition |
| ALG14ALG14 UDP-N-acetylglucosaminyltransferase subunit | Sometimes (5–29%) | In 1 condition |
| BICD2BICD cargo adaptor 2 | Sometimes (5–29%) | In 1 condition |
| COG8component of oligomeric golgi complex 8 | Sometimes (5–29%) | In 1 condition |
| DHX16DEAH-box helicase 16 | Sometimes (5–29%) | In 1 condition |
| DPAGT1dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 | Sometimes (5–29%) | In 1 condition |
| DPM1dolichyl-phosphate mannosyltransferase subunit 1, catalytic | Sometimes (5–29%) | In 2 conditions |
| ERLIN1ER lipid raft associated 1 | Sometimes (5–29%) | In 1 condition |
| ESCO2establishment of sister chromatid cohesion N-acetyltransferase 2 | Sometimes (5–29%) | In 2 conditions |
| FHL1four and a half LIM domains 1 | Sometimes (5–29%) | In 1 condition |
| GFPT1glutamine--fructose-6-phosphate transaminase 1 | Sometimes (5–29%) | In 1 condition |
| GMPPBGDP-mannose pyrophosphorylase B | Sometimes (5–29%) | In 1 condition |
| HACD13-hydroxyacyl-CoA dehydratase 1 | Sometimes (5–29%) | In 1 condition |
| ITGA7integrin subunit alpha 7 | Sometimes (5–29%) | In 1 condition |
| JAG2jagged canonical Notch ligand 2 | Sometimes (5–29%) | In 1 condition |
| KYkyphoscoliosis peptidase | Sometimes (5–29%) | In 1 condition |
| LMBRD2LMBR1 domain containing 2 | Sometimes (5–29%) | In 1 condition |
| LMX1BLIM homeobox transcription factor 1 beta | Sometimes (5–29%) | In 1 condition |
| MAP3K20mitogen-activated protein kinase kinase kinase 20 | Sometimes (5–29%) | In 1 condition |
| MEGF8multiple EGF like domains 8 | Sometimes (5–29%) | In 1 condition |
| MYL2myosin light chain 2 | Sometimes (5–29%) | In 1 condition |
| NEDD4LNEDD4 like E3 ubiquitin protein ligase | Sometimes (5–29%) | In 1 condition |
| PSAT1phosphoserine aminotransferase 1 | Sometimes (5–29%) | In 1 condition |
| RTTNrotatin | Sometimes (5–29%) | In 1 condition |
| SDHAsuccinate dehydrogenase complex flavoprotein subunit A | Sometimes (5–29%) | In 1 condition |
| SDHAF1succinate dehydrogenase complex assembly factor 1 | Sometimes (5–29%) | In 1 condition |
| SDHBsuccinate dehydrogenase complex iron sulfur subunit B | Sometimes (5–29%) | In 1 condition |
| SDHDsuccinate dehydrogenase complex subunit D | Sometimes (5–29%) | In 1 condition |
| SELENONselenoprotein N | Sometimes (5–29%) | In 1 condition |
| SLC25A46solute carrier family 25 member 46 | Sometimes (5–29%) | In 1 condition |
| SLC39A8solute carrier family 39 member 8 | Sometimes (5–29%) | In 1 condition |
| SLC6A1solute carrier family 6 member 1 | Sometimes (5–29%) | In 1 condition |
| SLC6A11solute carrier family 6 member 11 | Sometimes (5–29%) | In 1 condition |
| TELO2telomere maintenance 2 | Sometimes (5–29%) | In 1 condition |
| TPM2tropomyosin 2 | Sometimes (5–29%) | In 2 conditions |
| TPM3tropomyosin 3 | Sometimes (5–29%) | In 1 condition |
| UFC1ubiquitin-fold modifier conjugating enzyme 1 | Sometimes (5–29%) | In 1 condition |
| GJB2gap junction protein beta 2 | Rarely (1–4%) | In 2 conditions |
| GJB6gap junction protein beta 6 | Rarely (1–4%) | In 1 condition |
| ATP6V1E1ATPase H+ transporting V1 subunit E1 | Not recorded | In 1 condition |
| BAG3BAG cochaperone 3 | Not recorded | In 1 condition |
| C19orf12chromosome 19 open reading frame 12 | Not recorded | In 1 condition |
| CNTNAP1contactin associated protein 1 | Not recorded | In 1 condition |
| CPT2carnitine palmitoyltransferase 2 | Not recorded | In 1 condition |
| DDR2discoidin domain receptor tyrosine kinase 2 | Not recorded | In 1 condition |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Not recorded | In 1 condition |
| FLNAfilamin A | Not recorded | In 1 condition |
| PIEZO2piezo type mechanosensitive ion channel component 2 | Not recorded | In 1 condition |
| PIK3R2phosphoinositide-3-kinase regulatory subunit 2 | Not recorded | In 1 condition |
| PLOD2procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 | Not recorded | In 1 condition |
| PTDSS1phosphatidylserine synthase 1 | Not recorded | In 1 condition |
| PTH1Rparathyroid hormone 1 receptor | Not recorded | In 1 condition |
| RNU4ATACRNA, U4atac small nuclear | Not recorded | In 1 condition |
| SCARF2scavenger receptor class F member 2 | Not recorded | In 1 condition |
| TGFB2transforming growth factor beta 2 | Not recorded | In 1 condition |
| TRIM2tripartite motif containing 2 | Not recorded | In 1 condition |
| TRPV4transient receptor potential cation channel subfamily V member 4 | Not recorded | In 1 condition |
| ZBTB20zinc finger and BTB domain containing 20 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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