Trait
Loss of fat tissue in localized area
Clinical name: Lipoatrophy
Localized loss of fat tissue.
Summary
- Also called
- Atrophy of fat, Loss of fat tissue in localised area
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test81 genes linked to Loss of fat tissue in localized area
Changes in these genes cause rare conditions in which Loss of fat tissue in localized area is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| FBN1fibrillin 1 | Always | In 3 conditions |
| PLIN1perilipin 1 | Always | In 2 conditions |
| PPARGperoxisome proliferator activated receptor gamma | Always | In 1 condition |
| ACTBactin beta | Very often (80–99%) | In 1 condition |
| COL3A1collagen type III alpha 1 chain | Very often (80–99%) | In 1 condition |
| FUCA1alpha-L-fucosidase 1 | Very often (80–99%) | In 1 condition |
| LMNAlamin A/C | Very often (80–99%) | In 6 conditions |
| LMNB2lamin B2 | Very often (80–99%) | In 1 condition |
| PLAAT3phospholipase A and acyltransferase 3 | Very often (80–99%) | In 1 condition |
| POLR3ARNA polymerase III subunit A | Very often (80–99%) | In 2 conditions |
| SLC25A24solute carrier family 25 member 24 | Very often (80–99%) | In 1 condition |
| WRNWRN RecQ like helicase | Very often (80–99%) | In 1 condition |
| BANF1barrier to autointegration nuclear assembly factor 1 | Often (30–79%) | In 1 condition |
| CLMPCXADR like cell adhesion molecule | Often (30–79%) | In 1 condition |
| FLNAfilamin A | Often (30–79%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Often (30–79%) | In 2 conditions |
| RBM28RNA binding motif protein 28 | Often (30–79%) | In 1 condition |
| ABCC9ATP binding cassette subfamily C member 9 | Sometimes (5–29%) | In 1 condition |
| ACTC1actin alpha cardiac muscle 1 | Sometimes (5–29%) | In 1 condition |
| ACTN2actinin alpha 2 | Sometimes (5–29%) | In 1 condition |
| ANKRD1ankyrin repeat domain 1 | Sometimes (5–29%) | In 1 condition |
| BAG3BAG cochaperone 3 | Sometimes (5–29%) | In 1 condition |
| BAG5BAG cochaperone 5 | Sometimes (5–29%) | In 1 condition |
| CAP2cyclase associated actin cytoskeleton regulatory protein 2 | Sometimes (5–29%) | In 1 condition |
| CRYABcrystallin alpha B | Sometimes (5–29%) | In 1 condition |
| CSRP3cysteine and glycine rich protein 3 | Sometimes (5–29%) | In 1 condition |
| DESdesmin | Sometimes (5–29%) | In 1 condition |
| DMDdystrophin | Sometimes (5–29%) | In 1 condition |
| DOLKdolichol kinase | Sometimes (5–29%) | In 1 condition |
| DSG2desmoglein 2 | Sometimes (5–29%) | In 1 condition |
| DSPdesmoplakin | Sometimes (5–29%) | In 1 condition |
| FHL2four and a half LIM domains 2 | Sometimes (5–29%) | In 1 condition |
| FKTNfukutin | Sometimes (5–29%) | In 1 condition |
| FLNCfilamin C | Sometimes (5–29%) | In 1 condition |
| GATAD1GATA zinc finger domain containing 1 | Sometimes (5–29%) | In 1 condition |
| GET3guided entry of tail-anchored proteins factor 3, ATPase | Sometimes (5–29%) | In 1 condition |
| HAND2heart and neural crest derivatives expressed 2 | Sometimes (5–29%) | In 1 condition |
| JPH2junctophilin 2 | Sometimes (5–29%) | In 1 condition |
| LAMA4laminin subunit alpha 4 | Sometimes (5–29%) | In 1 condition |
| LDB3LIM domain binding 3 | Sometimes (5–29%) | In 1 condition |
Show 41 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| LMOD2leiomodin 2 | Sometimes (5–29%) | In 1 condition |
| MYBPC3myosin binding protein C3 | Sometimes (5–29%) | In 1 condition |
| MYH6myosin heavy chain 6 | Sometimes (5–29%) | In 1 condition |
| MYH7myosin heavy chain 7 | Sometimes (5–29%) | In 1 condition |
| MYPNmyopalladin | Sometimes (5–29%) | In 1 condition |
| NEXNnexilin F-actin binding protein | Sometimes (5–29%) | In 1 condition |
| NRAPnebulin related anchoring protein | Sometimes (5–29%) | In 1 condition |
| PLNphospholamban | Sometimes (5–29%) | In 1 condition |
| PPCSphosphopantothenoylcysteine synthetase | Sometimes (5–29%) | In 1 condition |
| PRDM16PR/SET domain 16 | Sometimes (5–29%) | In 1 condition |
| PSEN1presenilin 1 | Sometimes (5–29%) | In 1 condition |
| PSEN2presenilin 2 | Sometimes (5–29%) | In 1 condition |
| RAF1Raf-1 proto-oncogene, serine/threonine kinase | Sometimes (5–29%) | In 1 condition |
| RBM20RNA binding motif protein 20 | Sometimes (5–29%) | In 1 condition |
| RPL3Lribosomal protein L3 like | Sometimes (5–29%) | In 1 condition |
| SCN5Asodium voltage-gated channel alpha subunit 5 | Sometimes (5–29%) | In 1 condition |
| SDHAsuccinate dehydrogenase complex flavoprotein subunit A | Sometimes (5–29%) | In 1 condition |
| SGCDsarcoglycan delta | Sometimes (5–29%) | In 1 condition |
| TAF1ATATA-box binding protein associated factor, RNA polymerase I subunit A | Sometimes (5–29%) | In 1 condition |
| TAFAZZINtafazzin, phospholipid-lysophospholipid transacylase | Sometimes (5–29%) | In 1 condition |
| TCAPtitin-cap | Sometimes (5–29%) | In 1 condition |
| TMPOthymopoietin | Sometimes (5–29%) | In 1 condition |
| TNNC1troponin C1, slow skeletal and cardiac type | Sometimes (5–29%) | In 1 condition |
| TNNI3troponin I3, cardiac type | Sometimes (5–29%) | In 1 condition |
| TNNT2troponin T2, cardiac type | Sometimes (5–29%) | In 1 condition |
| TPM1tropomyosin 1 | Sometimes (5–29%) | In 1 condition |
| TTNtitin | Sometimes (5–29%) | In 1 condition |
| TXNRD2thioredoxin reductase 2 | Sometimes (5–29%) | In 1 condition |
| VCLvinculin | Sometimes (5–29%) | In 1 condition |
| VEZF1vascular endothelial zinc finger 1 | Sometimes (5–29%) | In 1 condition |
| ADARadenosine deaminase RNA specific | Rarely (1–4%) | In 1 condition |
| IFIH1interferon induced with helicase C domain 1 | Rarely (1–4%) | In 1 condition |
| LSM11LSM11, U7 small nuclear RNA associated | Rarely (1–4%) | In 1 condition |
| RNASEH2Aribonuclease H2 subunit A | Rarely (1–4%) | In 1 condition |
| RNASEH2Bribonuclease H2 subunit B | Rarely (1–4%) | In 1 condition |
| RNASEH2Cribonuclease H2 subunit C | Rarely (1–4%) | In 1 condition |
| RNU7-1RNA, U7 small nuclear 1 | Rarely (1–4%) | In 1 condition |
| SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Rarely (1–4%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Rarely (1–4%) | In 1 condition |
| PDGFRBplatelet derived growth factor receptor beta | Not recorded | In 1 condition |
| PIK3R1phosphoinositide-3-kinase regulatory subunit 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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