Trait
Drooping of both upper eyelids
Clinical name: Bilateral ptosis
Summary
- Body system
- Abnormality of the eye
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Drooping of both upper eyelids, and the rest of your genome, with one test.
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Get my Genome Test74 genes linked to Drooping of both upper eyelids
Changes in these genes cause rare conditions in which Drooping of both upper eyelids is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ACBD5acyl-CoA binding domain containing 5 | Always | In 1 condition |
| DNM1Ldynamin 1L | Always | In 2 conditions |
| DSTdystonin | Always | In 1 condition |
| GUK1guanylate kinase 1 | Always | In 1 condition |
| IDUAalpha-L-iduronidase | Always | In 1 condition |
| ISCUiron-sulfur cluster assembly enzyme | Always | In 1 condition |
| JPH1junctophilin 1 | Always | In 1 condition |
| KDM6Alysine demethylase 6A | Always | In 1 condition |
| KMT2Dlysine methyltransferase 2D | Always | In 1 condition |
| LRP12LDL receptor related protein 12 | Always | In 1 condition |
| NHEJ1non-homologous end joining factor 1 | Always | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Always | In 1 condition |
| PAX6paired box 6 | Always | In 1 condition |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Always | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Always | In 1 condition |
| RYR1ryanodine receptor 1 | Always | In 1 condition |
| SCN4Asodium voltage-gated channel alpha subunit 4 | Always | In 2 conditions |
| SOS1SOS Ras/Rac guanine nucleotide exchange factor 1 | Always | In 1 condition |
| TWIST1twist family bHLH transcription factor 1 | Always | In 1 condition |
| WT1WT1 transcription factor | Always | In 1 condition |
| ZNF407zinc finger protein 407 | Always | In 1 condition |
| DBHdopamine beta-hydroxylase | Very often (80–99%) | In 1 condition |
| GSNgelsolin | Very often (80–99%) | In 1 condition |
| ABCC8ATP binding cassette subfamily C member 8 | Often (30–79%) | In 2 conditions |
| AEBP1AE binding protein 1 | Often (30–79%) | In 2 conditions |
| ATXN7L3ataxin 7 like 3 | Often (30–79%) | In 1 condition |
| AUTS2activator of transcription and developmental regulator AUTS2 | Often (30–79%) | In 1 condition |
| CERT1ceramide transporter 1 | Often (30–79%) | In 1 condition |
| CHRNGcholinergic receptor nicotinic gamma subunit | Often (30–79%) | In 1 condition |
| COL13A1collagen type XIII alpha 1 chain | Often (30–79%) | In 1 condition |
| COLQcollagen like tail subunit of asymmetric acetylcholinesterase | Often (30–79%) | In 1 condition |
| DGUOKdeoxyguanosine kinase | Often (30–79%) | In 1 condition |
| GCKglucokinase | Often (30–79%) | In 1 condition |
| INSinsulin | Often (30–79%) | In 1 condition |
| KCNH1potassium voltage-gated channel subfamily H member 1 | Often (30–79%) | In 1 condition |
| KCNJ11potassium inwardly rectifying channel subfamily J member 11 | Often (30–79%) | In 3 conditions |
| LAMB2laminin subunit beta 2 | Often (30–79%) | In 1 condition |
| MAFMAF bZIP transcription factor | Often (30–79%) | In 1 condition |
| ODC1ornithine decarboxylase 1 | Often (30–79%) | In 1 condition |
| OPA1OPA1 mitochondrial dynamin like GTPase | Often (30–79%) | In 1 condition |
Show 34 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| PACS1phosphofurin acidic cluster sorting protein 1 | Often (30–79%) | In 1 condition |
| PDX1pancreatic and duodenal homeobox 1 | Often (30–79%) | In 1 condition |
| RAD21RAD21 cohesin complex component | Often (30–79%) | In 2 conditions |
| RNASEH1ribonuclease H1 | Often (30–79%) | In 2 conditions |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Often (30–79%) | In 1 condition |
| SPECC1Lsperm antigen with calponin homology and coiled-coil domains 1 like | Often (30–79%) | In 1 condition |
| STAC3SH3 and cysteine rich domain 3 | Often (30–79%) | In 1 condition |
| STAT3signal transducer and activator of transcription 3 | Often (30–79%) | In 1 condition |
| TUBB3tubulin beta 3 class III | Often (30–79%) | In 2 conditions |
| ADNPactivity dependent neuroprotector homeobox | Sometimes (5–29%) | In 2 conditions |
| ATP6V1B2ATPase H+ transporting V1 subunit B2 | Sometimes (5–29%) | In 1 condition |
| CDC42BPBCDC42 binding protein kinase beta | Sometimes (5–29%) | In 1 condition |
| CLCN3Cl-/H+ antiporter 3 | Sometimes (5–29%) | In 1 condition |
| COL2A1collagen type II alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| CRELD1CRELD disulfide isomerase 1 | Sometimes (5–29%) | In 1 condition |
| KDM1Alysine demethylase 1A | Sometimes (5–29%) | In 1 condition |
| LRRC7leucine rich repeat containing 7 | Sometimes (5–29%) | In 1 condition |
| NAA10N-alpha-acetyltransferase 10, NatA catalytic subunit | Sometimes (5–29%) | In 1 condition |
| NARS2asparaginyl-tRNA synthetase 2, mitochondrial | Sometimes (5–29%) | In 1 condition |
| NOTCH3notch receptor 3 | Sometimes (5–29%) | In 1 condition |
| NOVA2NOVA alternative splicing regulator 2 | Sometimes (5–29%) | In 1 condition |
| PDZD8PDZ domain containing 8 | Sometimes (5–29%) | In 1 condition |
| PLECplectin | Sometimes (5–29%) | In 1 condition |
| POLRMTRNA polymerase mitochondrial | Sometimes (5–29%) | In 1 condition |
| TBC1D24TBC1 domain family member 24 | Sometimes (5–29%) | In 1 condition |
| TUBA1Atubulin alpha 1a | Sometimes (5–29%) | In 1 condition |
| TUBB2Btubulin beta 2B class IIb | Sometimes (5–29%) | In 1 condition |
| TYMSthymidylate synthetase | Sometimes (5–29%) | In 1 condition |
| FLNAfilamin A | Rarely (1–4%) | In 1 condition |
| NGLY1N-glycanase 1 | Rarely (1–4%) | In 1 condition |
| PAHphenylalanine hydroxylase | Rarely (1–4%) | In 1 condition |
| PPP2R5Cprotein phosphatase 2 regulatory subunit B'gamma | Rarely (1–4%) | In 1 condition |
| KIF21Akinesin family member 21A | Not recorded | In 1 condition |
| PHOX2Apaired like homeobox 2A | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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