Trait

Fused wrist bones

Clinical name: Carpal synostosis

Synostosis (bony fusion) involving one or more bones of the carpus (scaphoid, lunate, triquetrum, trapezium, trapezoid, capitate, hamate, pisiform).

HPO HP:0009702

Also called: Carpal bone fusion, Carpal fusion, Fused carpal bones, Fusion of carpal bones, Synostosis involving the carpal bones
Body system: Abnormality of limbs Abnormality of the musculoskeletal system

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18 genes linked to Fused wrist bones

Changes in these genes cause rare conditions in which Fused wrist bones is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
BMPR1Bbone morphogenetic protein receptor type 1B	Always	In 1 condition
COL27A1collagen type XXVII alpha 1 chain	Always	In 1 condition
HOXA13homeobox A13	Always	In 1 condition
NOGnoggin	Always	In 4 conditions
MAP3K7mitogen-activated protein kinase kinase kinase 7	Very often (80–99%)	In 1 condition
FGFR3fibroblast growth factor receptor 3	Often (30–79%)	In 1 condition
FLNBfilamin B	Often (30–79%)	In 2 conditions
MYH3myosin heavy chain 3	Often (30–79%)	In 2 conditions
SALL4spalt like transcription factor 4	Often (30–79%)	In 1 condition
B3GALT6beta-1,3-galactosyltransferase 6	Sometimes (5–29%)	In 2 conditions
FLNAfilamin A	Sometimes (5–29%)	In 1 condition
CHSY1chondroitin sulfate synthase 1	Not recorded	In 1 condition
GDF5growth differentiation factor 5	Not recorded	In 1 condition
HOXD13homeobox D13	Not recorded	In 1 condition
PAX3paired box 3	Not recorded	In 1 condition
PORcytochrome p450 oxidoreductase	Not recorded	In 1 condition
RBM8ARNA binding motif protein 8A	Not recorded	In 1 condition
RECQL4RecQ like helicase 4	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormal wrist bones Fused hand bones Wrist bone/ankle bone fusions

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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