Trait
Decreased body weight
Abnormally low body weight.
Summary
- Also called
- Decreased weight, Low body weight, Low weight, Weight less than 3rd percentile
- Body system
- Growth abnormality
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Decreased body weight, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test119 genes linked to Decreased body weight
Changes in these genes cause rare conditions in which Decreased body weight is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ATP5F1BATP synthase F1 subunit beta | Always | In 1 condition |
| BMP1bone morphogenetic protein 1 | Always | In 1 condition |
| CCDC47coiled-coil domain containing 47 | Always | In 1 condition |
| CCDC8coiled-coil domain containing 8 subunit of 3M complex | Always | In 1 condition |
| CENPTcentromere protein T | Always | In 1 condition |
| COPB2coat protein complex I subunit beta 2 | Always | In 1 condition |
| COX4I1cytochrome c oxidase subunit 4I1 | Always | In 1 condition |
| CPAPcentrosome assembly and centriole elongation protein | Always | In 1 condition |
| CRIPTCXXC repeat containing interactor of PDZ3 domain | Always | In 1 condition |
| DNA2DNA replication helicase/nuclease 2 | Always | In 1 condition |
| DPP6dipeptidyl peptidase like 6 | Always | In 1 condition |
| ESAMendothelial cell adhesion molecule | Always | In 1 condition |
| FANCIFA complementation group I | Always | In 1 condition |
| IGF1insulin like growth factor 1 | Always | In 1 condition |
| IGF2insulin like growth factor 2 | Always | In 2 conditions |
| IKZF2IKAROS family zinc finger 2 | Always | In 1 condition |
| INTUinturned planar cell polarity protein | Always | In 1 condition |
| ITPR1inositol 1,4,5-trisphosphate receptor type 1 | Always | In 1 condition |
| KCNA4potassium voltage-gated channel subfamily A member 4 | Always | In 1 condition |
| KDM5Clysine demethylase 5C | Always | In 1 condition |
| KRT10keratin 10 | Always | In 1 condition |
| MALT1MALT1 paracaspase | Always | In 1 condition |
| MBTPS1membrane bound transcription factor peptidase, site 1 | Always | In 1 condition |
| MCM5minichromosome maintenance complex component 5 | Always | In 1 condition |
| MCM9minichromosome maintenance 9 homologous recombination repair factor | Always | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Always | In 1 condition |
| NFIXnuclear factor I X | Always | In 1 condition |
| OFD1OFD1 centriole and centriolar satellite protein | Always | In 1 condition |
| POLEDNA polymerase epsilon, catalytic subunit | Always | In 1 condition |
| PPP3CAprotein phosphatase 3 catalytic subunit alpha | Always | In 1 condition |
| PTH1Rparathyroid hormone 1 receptor | Always | In 1 condition |
| RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1 | Always | In 1 condition |
| RFC4replication factor C subunit 4 | Always | In 1 condition |
| RTTNrotatin | Always | In 1 condition |
| SEL1LSEL1L adaptor subunit of SYVN1 ubiquitin ligase | Always | In 2 conditions |
| SGO1shugoshin 1 | Always | In 1 condition |
| SPRTNSprT-like N-terminal domain | Always | In 1 condition |
| TOP3ADNA topoisomerase III alpha | Always | In 1 condition |
| WBP4WW domain binding protein 4 | Always | In 1 condition |
| WDR4WDR4 tRNA N7-guanosine methyltransferase non-catalytic subunit | Always | In 2 conditions |
Show 79 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| ACO2aconitase 2 | Very often (80–99%) | In 1 condition |
| COL7A1collagen type VII alpha 1 chain | Very often (80–99%) | In 1 condition |
| GHSRgrowth hormone secretagogue receptor | Very often (80–99%) | In 1 condition |
| LARP7La ribonucleoprotein 7, transcriptional regulator | Very often (80–99%) | In 1 condition |
| LMNAlamin A/C | Very often (80–99%) | In 1 condition |
| PQBP1polyglutamine binding protein 1 | Very often (80–99%) | In 2 conditions |
| SELENONselenoprotein N | Very often (80–99%) | In 1 condition |
| ALG2ALG2 alpha-1,3/1,6-mannosyltransferase | Often (30–79%) | In 1 condition |
| AMPD2adenosine monophosphate deaminase 2 | Often (30–79%) | In 1 condition |
| ASPMassembly factor for spindle microtubules | Often (30–79%) | In 1 condition |
| CDC45cell division cycle 45 | Often (30–79%) | In 1 condition |
| CDK10cyclin dependent kinase 10 | Often (30–79%) | In 1 condition |
| CILK1ciliogenesis associated kinase 1 | Often (30–79%) | In 1 condition |
| DDX3XDEAD-box helicase 3 X-linked | Often (30–79%) | In 1 condition |
| DIAPH1diaphanous related formin 1 | Often (30–79%) | In 1 condition |
| DNAJC3DnaJ heat shock protein family (Hsp40) member C3 | Often (30–79%) | In 1 condition |
| EIF2AK3eukaryotic translation initiation factor 2 alpha kinase 3 | Often (30–79%) | In 1 condition |
| ELFN1extracellular leucine rich repeat and fibronectin type III domain containing 1 | Often (30–79%) | In 1 condition |
| FRYLFRY like transcription coactivator | Often (30–79%) | In 1 condition |
| GOT2glutamic-oxaloacetic transaminase 2 | Often (30–79%) | In 1 condition |
| H19H19 imprinted maternally expressed transcript | Often (30–79%) | In 1 condition |
| INPP4Ainositol polyphosphate-4-phosphatase type I A | Often (30–79%) | In 1 condition |
| INSRinsulin receptor | Often (30–79%) | In 1 condition |
| KICS2KICSTOR subunit 2 | Often (30–79%) | In 1 condition |
| MADDMAP kinase activating death domain | Often (30–79%) | In 2 conditions |
| MITFmelanocyte inducing transcription factor | Often (30–79%) | In 1 condition |
| OTUD6BOTU deubiquitinase 6B | Often (30–79%) | In 2 conditions |
| PAN2poly(A) specific ribonuclease subunit PAN2 | Often (30–79%) | In 1 condition |
| PDHBpyruvate dehydrogenase E1 subunit beta | Often (30–79%) | In 1 condition |
| PLAG1PLAG1 zinc finger | Often (30–79%) | In 1 condition |
| POLR1ARNA polymerase I subunit A | Often (30–79%) | In 1 condition |
| PPP1R15Bprotein phosphatase 1 regulatory subunit 15B | Often (30–79%) | In 1 condition |
| PUS7pseudouridine synthase 7 | Often (30–79%) | In 1 condition |
| TBL1XR1TBL1X/Y related 1 | Often (30–79%) | In 1 condition |
| TRA2Btransformer 2 beta homolog | Often (30–79%) | In 1 condition |
| TRMT10AtRNA methyltransferase 10A | Often (30–79%) | In 1 condition |
| ALG13ALG13 UDP-N-acetylglucosaminyltransferase subunit | Sometimes (5–29%) | In 1 condition |
| BCORBCL6 corepressor | Sometimes (5–29%) | In 1 condition |
| DMPKDM1 protein kinase | Sometimes (5–29%) | In 1 condition |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Sometimes (5–29%) | In 1 condition |
| FBN1fibrillin 1 | Sometimes (5–29%) | In 1 condition |
| HSPG2heparan sulfate proteoglycan 2 | Sometimes (5–29%) | In 1 condition |
| LAMA2laminin subunit alpha 2 | Sometimes (5–29%) | In 1 condition |
| MED12mediator complex subunit 12 | Sometimes (5–29%) | In 1 condition |
| MYL11myosin light chain 11 | Sometimes (5–29%) | In 1 condition |
| OXCT13-oxoacid CoA-transferase 1 | Sometimes (5–29%) | In 1 condition |
| PSMC3proteasome 26S subunit, ATPase 3 | Sometimes (5–29%) | In 1 condition |
| RNU2-2RNA, U2 small nuclear 2 | Sometimes (5–29%) | In 1 condition |
| SATB1SATB homeobox 1 | Sometimes (5–29%) | In 1 condition |
| TRAF7TNF receptor associated factor 7 | Sometimes (5–29%) | In 1 condition |
| XYLT2xylosyltransferase 2 | Sometimes (5–29%) | In 1 condition |
| SPTBN1spectrin beta, non-erythrocytic 1 | Rarely (1–4%) | In 1 condition |
| ANKLE2ankyrin repeat and LEM domain containing 2 | Not recorded | In 1 condition |
| ARCN1archain 1 coat protein complex I subunit delta | Not recorded | In 1 condition |
| ASPNATaspartate N-acetyltransferase | Not recorded | In 1 condition |
| ATP6V1E1ATPase H+ transporting V1 subunit E1 | Not recorded | In 1 condition |
| B3GALT6beta-1,3-galactosyltransferase 6 | Not recorded | In 2 conditions |
| B3GLCTbeta 3-glucosyltransferase | Not recorded | In 1 condition |
| CASKcalcium/calmodulin dependent serine protein kinase | Not recorded | In 1 condition |
| CKAP2Lcytoskeleton associated protein 2L | Not recorded | In 1 condition |
| DNMT3ADNA methyltransferase 3 alpha | Not recorded | In 1 condition |
| ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit | Not recorded | In 1 condition |
| FLNAfilamin A | Not recorded | In 1 condition |
| GBA1glucosylceramidase beta 1 | Not recorded | In 2 conditions |
| IFIH1interferon induced with helicase C domain 1 | Not recorded | In 1 condition |
| IGF1Rinsulin like growth factor 1 receptor | Not recorded | In 1 condition |
| KDM6Alysine demethylase 6A | Not recorded | In 1 condition |
| NGLY1N-glycanase 1 | Not recorded | In 1 condition |
| PCGF2polycomb group ring finger 2 | Not recorded | In 1 condition |
| PCLOpiccolo presynaptic cytomatrix protein | Not recorded | In 1 condition |
| PEX19peroxisomal biogenesis factor 19 | Not recorded | In 1 condition |
| RAB33BRAB33B, member RAS oncogene family | Not recorded | In 1 condition |
| RIN2Ras and Rab interactor 2 | Not recorded | In 1 condition |
| RPS6KA3ribosomal protein S6 kinase A3 | Not recorded | In 1 condition |
| SAMD9sterile alpha motif domain containing 9 | Not recorded | In 1 condition |
| SLC9A6solute carrier family 9 member A6 | Not recorded | In 1 condition |
| TBC1D23TBC1 domain family member 23 | Not recorded | In 1 condition |
| UBTFupstream binding transcription factor | Not recorded | In 1 condition |
| YY1AP1YY1 associated protein 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks