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Trait
Knock knees
Clinical name: Genu valgum
The legs angle inward, such that the knees are close together and the ankles far apart.
Summary
- Also called
- Genu valga, Genu valgus, Genua valga, Knee joint valgus deformity
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This page as data
Add .json to the page's address, or ask for application/json, to read it as JSON.
library(jsonlite)
url <- "https://dantelabs.com/traits/genu-valgum.json"
page <- fromJSON(url)
page$trait$nameKnock kneesHP:0002857
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Get my Genome Test176 genes linked to Knock knees
Changes in these genes cause rare conditions in which Knock knees is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ARSKarylsulfatase family member K | Always | In 1 condition |
| BNIP1BCL2 interacting protein 1 | Always | In 1 condition |
| CLDN16claudin 16 | Always | In 1 condition |
| COL9A1collagen type IX alpha 1 chain | Always | In 2 conditions |
| CSGALNACT1chondroitin sulfate N-acetylgalactosaminyltransferase 1 | Always | In 1 condition |
| FDXRferredoxin reductase | Always | In 1 condition |
| FLNAfilamin A | Always | In 2 conditions |
| GALNSgalactosamine (N-acetyl)-6-sulfatase | Always | In 1 condition |
| GNPTGN-acetylglucosamine-1-phosphate transferase subunit gamma | Always | In 1 condition |
| KDM2Blysine demethylase 2B | Always | In 1 condition |
| KDM6Blysine demethylase 6B | Always | In 1 condition |
| KIF7kinesin family member 7 | Always | In 2 conditions |
| LBRlamin B receptor | Always | In 1 condition |
| MED16mediator complex subunit 16 | Always | In 1 condition |
| NDUFAF6NADH:ubiquinone oxidoreductase complex assembly factor 6 | Always | In 1 condition |
| P4HTMprolyl 4-hydroxylase, transmembrane | Always | In 1 condition |
| PHEXphosphate regulating endopeptidase X-linked | Always | In 2 conditions |
| PHLDB1pleckstrin homology like domain family B member 1 | Always | In 1 condition |
| PRKACAprotein kinase cAMP-activated catalytic subunit alpha | Always | In 2 conditions |
| PSMD12proteasome 26S subunit, non-ATPase 12 | Always | In 1 condition |
| RAB33BRAB33B, member RAS oncogene family | Always | In 1 condition |
| RMP64ribonuclease MRP subunit p64 | Always | In 1 condition |
| RNU6ATACRNA, U6atac small nuclear | Always | In 1 condition |
| SCARF2scavenger receptor class F member 2 | Always | In 1 condition |
| SRSF1serine and arginine rich splicing factor 1 | Always | In 1 condition |
| TRPV4transient receptor potential cation channel subfamily V member 4 | Always | In 3 conditions |
| UNC13Aunc-13 homolog A | Always | In 1 condition |
| ZPR1ZPR1 zinc finger | Always | In 1 condition |
| ARSBarylsulfatase B | Very often (80–99%) | In 1 condition |
| CHST3carbohydrate sulfotransferase 3 | Very often (80–99%) | In 3 conditions |
| CYP19A1cytochrome P450 family 19 subfamily A member 1 | Very often (80–99%) | In 1 condition |
| DYMdymeclin | Very often (80–99%) | In 3 conditions |
| DYNC2LI1dynein cytoplasmic 2 light intermediate chain 1 | Very often (80–99%) | In 1 condition |
| EVCEvC ciliary complex subunit 1 | Very often (80–99%) | In 2 conditions |
| EVC2EvC ciliary complex subunit 2 | Very often (80–99%) | In 2 conditions |
| GLI1GLI family zinc finger 1 | Very often (80–99%) | In 2 conditions |
| HSPG2heparan sulfate proteoglycan 2 | Very often (80–99%) | In 1 condition |
| IARS2isoleucyl-tRNA synthetase 2, mitochondrial | Very often (80–99%) | In 2 conditions |
| LONP1lon peptidase 1, mitochondrial | Very often (80–99%) | In 1 condition |
| PRKACBprotein kinase cAMP-activated catalytic subunit beta | Very often (80–99%) | In 2 conditions |
Show 136 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SFRP4secreted frizzled related protein 4 | Very often (80–99%) | In 2 conditions |
| SHOXSHOX homeobox | Very often (80–99%) | In 2 conditions |
| SLC26A2solute carrier family 26 member 2 | Very often (80–99%) | In 4 conditions |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Often (30–79%) | In 1 condition |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Often (30–79%) | In 1 condition |
| CBScystathionine beta-synthase | Often (30–79%) | In 1 condition |
| CENPTcentromere protein T | Often (30–79%) | In 1 condition |
| CLCN7Cl-/H+ antiporter 7 | Often (30–79%) | In 1 condition |
| CLIP2CAP-Gly domain containing linker protein 2 | Often (30–79%) | In 1 condition |
| COL10A1collagen type X alpha 1 chain | Often (30–79%) | In 1 condition |
| COL11A1collagen type XI alpha 1 chain | Often (30–79%) | In 1 condition |
| COL1A2collagen type I alpha 2 chain | Often (30–79%) | In 1 condition |
| COL2A1collagen type II alpha 1 chain | Often (30–79%) | In 7 conditions |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Often (30–79%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Often (30–79%) | In 1 condition |
| ELNelastin | Often (30–79%) | In 1 condition |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Often (30–79%) | In 1 condition |
| FN1fibronectin 1 | Often (30–79%) | In 1 condition |
| GLB1galactosidase beta 1 | Often (30–79%) | In 1 condition |
| GTF2Igeneral transcription factor IIi | Often (30–79%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Often (30–79%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Often (30–79%) | In 1 condition |
| GUSBglucuronidase beta | Often (30–79%) | In 1 condition |
| HBBhemoglobin subunit beta | Often (30–79%) | In 2 conditions |
| KAT6Alysine acetyltransferase 6A | Often (30–79%) | In 1 condition |
| KIF22kinesin family member 22 | Often (30–79%) | In 2 conditions |
| LIFRLIF receptor subunit alpha | Often (30–79%) | In 1 condition |
| LIMK1LIM domain kinase 1 | Often (30–79%) | In 1 condition |
| MATN3matrilin 3 | Often (30–79%) | In 2 conditions |
| MCTP2multiple C2 and transmembrane domain containing 2 | Often (30–79%) | In 1 condition |
| MEGF8multiple EGF like domains 8 | Often (30–79%) | In 1 condition |
| METTL27methyltransferase like 27 | Often (30–79%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Often (30–79%) | In 1 condition |
| PEPDpeptidase D | Often (30–79%) | In 1 condition |
| PRKG2protein kinase cGMP-dependent 2 | Often (30–79%) | In 1 condition |
| RAB23RAB23, member RAS oncogene family | Often (30–79%) | In 2 conditions |
| RFC2replication factor C subunit 2 | Often (30–79%) | In 1 condition |
| RSPRY1ring finger and SPRY domain containing 1 | Often (30–79%) | In 1 condition |
| SLC10A7solute carrier family 10 member 7 | Often (30–79%) | In 1 condition |
| STX1Asyntaxin 1A | Often (30–79%) | In 1 condition |
| TBC1D7TBC1 domain family member 7 | Often (30–79%) | In 2 conditions |
| TBL2transducin beta like 2 | Often (30–79%) | In 1 condition |
| TMEM270transmembrane protein 270 | Often (30–79%) | In 1 condition |
| TONSLtonsoku like, DNA repair protein | Often (30–79%) | In 2 conditions |
| UGP2UDP-glucose pyrophosphorylase 2 | Often (30–79%) | In 1 condition |
| VPS13Bvacuolar protein sorting 13 homolog B | Often (30–79%) | In 2 conditions |
| VPS37DVPS37D subunit of ESCRT-I | Often (30–79%) | In 1 condition |
| ACTA1actin alpha 1, skeletal muscle | Sometimes (5–29%) | In 1 condition |
| ADNPactivity dependent neuroprotector homeobox | Sometimes (5–29%) | In 1 condition |
| ATP7AATPase copper transporting alpha | Sometimes (5–29%) | In 2 conditions |
| B3GAT3beta-1,3-glucuronyltransferase 3 | Sometimes (5–29%) | In 1 condition |
| BCORBCL6 corepressor | Sometimes (5–29%) | In 1 condition |
| BPNT23'(2'), 5'-bisphosphate nucleotidase 2 | Sometimes (5–29%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Sometimes (5–29%) | In 1 condition |
| BRF1BRF1 general transcription factor IIIB subunit | Sometimes (5–29%) | In 1 condition |
| CAMK2Acalcium/calmodulin dependent protein kinase II alpha | Sometimes (5–29%) | In 1 condition |
| CBFBcore-binding factor subunit beta | Sometimes (5–29%) | In 1 condition |
| CCN2cellular communication network factor 2 | Sometimes (5–29%) | In 1 condition |
| CCN6cellular communication network factor 6 | Sometimes (5–29%) | In 1 condition |
| CFL2cofilin 2 | Sometimes (5–29%) | In 1 condition |
| COG5component of oligomeric golgi complex 5 | Sometimes (5–29%) | In 1 condition |
| COL9A2collagen type IX alpha 2 chain | Sometimes (5–29%) | In 1 condition |
| COL9A3collagen type IX alpha 3 chain | Sometimes (5–29%) | In 1 condition |
| COMPcartilage oligomeric matrix protein | Sometimes (5–29%) | In 4 conditions |
| EXT1exostosin glycosyltransferase 1 | Sometimes (5–29%) | In 3 conditions |
| EXT2exostosin glycosyltransferase 2 | Sometimes (5–29%) | In 2 conditions |
| FBN1fibrillin 1 | Sometimes (5–29%) | In 1 condition |
| GANgigaxonin | Sometimes (5–29%) | In 1 condition |
| H3-3BH3.3 histone B | Sometimes (5–29%) | In 1 condition |
| HEATR3HEAT repeat containing 3 | Sometimes (5–29%) | In 1 condition |
| HS2ST1heparan sulfate 2-O-sulfotransferase 1 | Sometimes (5–29%) | In 1 condition |
| HS6ST1heparan sulfate 6-O-sulfotransferase 1 | Sometimes (5–29%) | In 1 condition |
| IDH1isocitrate dehydrogenase (NADP(+)) 1 | Sometimes (5–29%) | In 1 condition |
| IDH2isocitrate dehydrogenase (NADP(+)) 2 | Sometimes (5–29%) | In 1 condition |
| IFT172intraflagellar transport 172 | Sometimes (5–29%) | In 1 condition |
| IPO8importin 8 | Sometimes (5–29%) | In 1 condition |
| KLHL41kelch like family member 41 | Sometimes (5–29%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Sometimes (5–29%) | In 1 condition |
| LMOD3leiomodin 3 | Sometimes (5–29%) | In 1 condition |
| MAN2B1mannosidase alpha class 2B member 1 | Sometimes (5–29%) | In 1 condition |
| MAP2K1mitogen-activated protein kinase kinase 1 | Sometimes (5–29%) | In 1 condition |
| MAP2K2mitogen-activated protein kinase kinase 2 | Sometimes (5–29%) | In 1 condition |
| MPZmyelin protein zero | Sometimes (5–29%) | In 1 condition |
| MTX2metaxin 2 | Sometimes (5–29%) | In 1 condition |
| NAA60N-alpha-acetyltransferase 60, NatF catalytic subunit | Sometimes (5–29%) | In 1 condition |
| NEBnebulin | Sometimes (5–29%) | In 1 condition |
| NF1neurofibromin 1 | Sometimes (5–29%) | In 2 conditions |
| OCRLOCRL inositol polyphosphate-5-phosphatase | Sometimes (5–29%) | In 2 conditions |
| PLAAT3phospholipase A and acyltransferase 3 | Sometimes (5–29%) | In 1 condition |
| PMP22peripheral myelin protein 22 | Sometimes (5–29%) | In 1 condition |
| PTH1Rparathyroid hormone 1 receptor | Sometimes (5–29%) | In 1 condition |
| PUS3pseudouridine synthase 3 | Sometimes (5–29%) | In 1 condition |
| RAD21RAD21 cohesin complex component | Sometimes (5–29%) | In 1 condition |
| RPGRIP1LRPGRIP1 like | Sometimes (5–29%) | In 1 condition |
| RUNX2RUNX family transcription factor 2 | Sometimes (5–29%) | In 1 condition |
| SF3B2splicing factor 3b subunit 2 | Sometimes (5–29%) | In 1 condition |
| SKISKI proto-oncogene | Sometimes (5–29%) | In 2 conditions |
| SPARTspartin | Sometimes (5–29%) | In 1 condition |
| TFE3transcription factor binding to IGHM enhancer 3 | Sometimes (5–29%) | In 1 condition |
| TGDSTDP-glucose 4,6-dehydratase | Sometimes (5–29%) | In 1 condition |
| TGFB1transforming growth factor beta 1 | Sometimes (5–29%) | In 2 conditions |
| TPM2tropomyosin 2 | Sometimes (5–29%) | In 1 condition |
| TRPS1transcriptional repressor GATA binding 1 | Sometimes (5–29%) | In 1 condition |
| TUBB3tubulin beta 3 class III | Sometimes (5–29%) | In 1 condition |
| VDRvitamin D receptor | Sometimes (5–29%) | In 1 condition |
| ZEB2zinc finger E-box binding homeobox 2 | Sometimes (5–29%) | In 2 conditions |
| ZNF699zinc finger protein 699 | Sometimes (5–29%) | In 1 condition |
| CTCFCCCTC-binding factor | Rarely (1–4%) | In 1 condition |
| SPTBN1spectrin beta, non-erythrocytic 1 | Rarely (1–4%) | In 1 condition |
| ACANaggrecan | Not recorded | In 1 condition |
| ATRXATRX chromatin remodeler | Not recorded | In 1 condition |
| B3GALT6beta-1,3-galactosyltransferase 6 | Not recorded | In 1 condition |
| CTC1CST telomere replication complex component 1 | Not recorded | In 1 condition |
| CTNScystinosin, lysosomal cystine transporter | Not recorded | In 1 condition |
| EIF2AK3eukaryotic translation initiation factor 2 alpha kinase 3 | Not recorded | In 1 condition |
| ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 | Not recorded | In 1 condition |
| HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2 | Not recorded | In 1 condition |
| IDUAalpha-L-iduronidase | Not recorded | In 1 condition |
| IFIH1interferon induced with helicase C domain 1 | Not recorded | In 1 condition |
| IFT57intraflagellar transport 57 | Not recorded | In 1 condition |
| MAGEL2MAGE family member L2 | Not recorded | In 1 condition |
| MKRN3makorin ring finger protein 3 | Not recorded | In 1 condition |
| MMP13matrix metallopeptidase 13 | Not recorded | In 1 condition |
| NKX3-2NK3 homeobox 2 | Not recorded | In 1 condition |
| NOTCH2notch receptor 2 | Not recorded | In 1 condition |
| NPAP1nuclear pore associated protein 1 | Not recorded | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Not recorded | In 1 condition |
| ORC1origin recognition complex subunit 1 | Not recorded | In 1 condition |
| PWAR1Prader Willi/Angelman region RNA 1 | Not recorded | In 1 condition |
| PWRN1Prader-Willi region non-protein coding RNA 1 | Not recorded | In 1 condition |
| SERPINH1serpin family H member 1 | Not recorded | In 1 condition |
| SNORD115-1small nucleolar RNA, C/D box 115-1 | Not recorded | In 1 condition |
| SNORD116-1small nucleolar RNA, C/D box 116-1 | Not recorded | In 1 condition |
| TNFSF11TNF superfamily member 11 | Not recorded | In 1 condition |
| WNT7AWnt family member 7A | Not recorded | In 1 condition |
| ZBTB20zinc finger and BTB domain containing 20 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Who We HelpOur ScienceProductsOutcomes
Log InAskGet Startedfrom $449
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks