Trait
Broad thumb
Increased thumb width without increased dorso-ventral dimension.
Summary
- Also called
- Broad thumbs, Wide/broad thumb, Broad phalanges of the thumb, Wide/broad thumb phalanges
Reference genomeGRCh38hg38
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Get my Genome Test93 genes linked to Broad thumb
Changes in these genes cause rare conditions in which Broad thumb is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ACANaggrecan | Always | In 2 conditions |
| DNM1Ldynamin 1L | Always | In 1 condition |
| EXOSC2exosome component 2 | Always | In 1 condition |
| FLNAfilamin A | Always | In 3 conditions |
| GLI3GLI family zinc finger 3 | Always | In 4 conditions |
| HYAL2hyaluronidase 2 | Always | In 1 condition |
| MED12mediator complex subunit 12 | Always | In 2 conditions |
| MIR140microRNA 140 | Always | In 1 condition |
| NXNnucleoredoxin | Always | In 2 conditions |
| PAN2poly(A) specific ribonuclease subunit PAN2 | Always | In 1 condition |
| REREarginine-glutamic acid dipeptide repeats | Always | In 1 condition |
| SLC13A1solute carrier family 13 member 1 | Always | In 1 condition |
| SNIP1Smad nuclear interacting protein 1 | Always | In 1 condition |
| CREBBPCREB binding lysine acetyltransferase | Very often (80–99%) | In 3 conditions |
| EP300EP300 lysine acetyltransferase | Very often (80–99%) | In 3 conditions |
| FGFR1fibroblast growth factor receptor 1 | Very often (80–99%) | In 3 conditions |
| FGFR2fibroblast growth factor receptor 2 | Very often (80–99%) | In 7 conditions |
| FLNBfilamin B | Very often (80–99%) | In 1 condition |
| GPC4glypican 4 | Very often (80–99%) | In 3 conditions |
| KCNH1potassium voltage-gated channel subfamily H member 1 | Very often (80–99%) | In 2 conditions |
| MAP3K7mitogen-activated protein kinase kinase kinase 7 | Very often (80–99%) | In 2 conditions |
| NOGnoggin | Very often (80–99%) | In 2 conditions |
| PPP2R3Cprotein phosphatase 2 regulatory subunit B''gamma | Very often (80–99%) | In 1 condition |
| DVL1dishevelled segment polarity protein 1 | Often (30–79%) | In 2 conditions |
| EZH2enhancer of zeste 2 polycomb repressive complex 2 subunit | Often (30–79%) | In 2 conditions |
| FGF9fibroblast growth factor 9 | Often (30–79%) | In 2 conditions |
| FGFR3fibroblast growth factor receptor 3 | Often (30–79%) | In 2 conditions |
| GDF5growth differentiation factor 5 | Often (30–79%) | In 1 condition |
| GDF6growth differentiation factor 6 | Often (30–79%) | In 1 condition |
| GPC3glypican 3 | Often (30–79%) | In 2 conditions |
| HNRNPRheterogeneous nuclear ribonucleoprotein R | Often (30–79%) | In 1 condition |
| HPGD15-hydroxyprostaglandin dehydrogenase | Often (30–79%) | In 1 condition |
| MEGF8multiple EGF like domains 8 | Often (30–79%) | In 2 conditions |
| NSD1nuclear receptor binding SET domain protein 1 | Often (30–79%) | In 1 condition |
| OFD1OFD1 centriole and centriolar satellite protein | Often (30–79%) | In 1 condition |
| OTUD6BOTU deubiquitinase 6B | Often (30–79%) | In 2 conditions |
| PRKD1protein kinase D1 | Often (30–79%) | In 1 condition |
| PRKG2protein kinase cGMP-dependent 2 | Often (30–79%) | In 1 condition |
| RAB23RAB23, member RAS oncogene family | Often (30–79%) | In 1 condition |
| RBM8ARNA binding motif protein 8A | Often (30–79%) | In 2 conditions |
Show 53 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| ROR2ROR family WNT receptor 2 | Often (30–79%) | In 3 conditions |
| SALL1spalt like transcription factor 1 | Often (30–79%) | In 2 conditions |
| SATB2SATB homeobox 2 | Often (30–79%) | In 3 conditions |
| SIAH1siah E3 ubiquitin protein ligase 1 | Often (30–79%) | In 1 condition |
| SMOsmoothened, frizzled class receptor | Often (30–79%) | In 2 conditions |
| SRCAPSnf2 related CREBBP activator protein | Often (30–79%) | In 1 condition |
| SUMF1sulfatase modifying factor 1 | Often (30–79%) | In 2 conditions |
| SUZ12SUZ12 polycomb repressive complex 2 subunit | Often (30–79%) | In 1 condition |
| TWIST1twist family bHLH transcription factor 1 | Often (30–79%) | In 2 conditions |
| USP9Xubiquitin specific peptidase 9 X-linked | Often (30–79%) | In 1 condition |
| XYLT1xylosyltransferase 1 | Often (30–79%) | In 2 conditions |
| ZNF668zinc finger protein 668 | Often (30–79%) | In 1 condition |
| BICRABRD4 interacting chromatin remodeling complex associated protein | Sometimes (5–29%) | In 1 condition |
| BMP2bone morphogenetic protein 2 | Sometimes (5–29%) | In 1 condition |
| BMPR1Abone morphogenetic protein receptor type 1A | Sometimes (5–29%) | In 1 condition |
| BORCS8BLOC-1 related complex subunit 8 | Sometimes (5–29%) | In 1 condition |
| BPTFbromodomain PHD finger transcription factor | Sometimes (5–29%) | In 1 condition |
| CBFBcore-binding factor subunit beta | Sometimes (5–29%) | In 1 condition |
| DACT1dishevelled binding antagonist of beta catenin 1 | Sometimes (5–29%) | In 1 condition |
| DHX30DExH-box helicase 30 | Sometimes (5–29%) | In 1 condition |
| DVL3dishevelled segment polarity protein 3 | Sometimes (5–29%) | In 1 condition |
| GATA4GATA binding protein 4 | Sometimes (5–29%) | In 1 condition |
| H3-3AH3.3 histone A | Sometimes (5–29%) | In 1 condition |
| IFT56intraflagellar transport 56 | Sometimes (5–29%) | In 1 condition |
| INPPL1inositol polyphosphate phosphatase like 1 | Sometimes (5–29%) | In 1 condition |
| KCTD1potassium channel tetramerization domain containing 1 | Sometimes (5–29%) | In 1 condition |
| LMBR1limb development membrane protein 1 | Sometimes (5–29%) | In 1 condition |
| MAN2C1mannosidase alpha class 2C member 1 | Sometimes (5–29%) | In 1 condition |
| PACS1phosphofurin acidic cluster sorting protein 1 | Sometimes (5–29%) | In 1 condition |
| PCDHGC4protocadherin gamma subfamily C, 4 | Sometimes (5–29%) | In 1 condition |
| PIGBphosphatidylinositol glycan anchor biosynthesis class B | Sometimes (5–29%) | In 1 condition |
| POGZpogo transposable element derived with ZNF domain | Sometimes (5–29%) | In 1 condition |
| PSMD12proteasome 26S subunit, non-ATPase 12 | Sometimes (5–29%) | In 1 condition |
| PTENphosphatase and tensin homolog | Sometimes (5–29%) | In 2 conditions |
| PUF60poly(U) binding splicing factor 60 | Sometimes (5–29%) | In 1 condition |
| PYCR2pyrroline-5-carboxylate reductase 2 | Sometimes (5–29%) | In 1 condition |
| RNU5B-1RNA, U5B small nuclear 1 | Sometimes (5–29%) | In 1 condition |
| SLC6A1solute carrier family 6 member 1 | Sometimes (5–29%) | In 1 condition |
| SLC6A11solute carrier family 6 member 11 | Sometimes (5–29%) | In 1 condition |
| SMOC1SPARC related modular calcium binding 1 | Sometimes (5–29%) | In 1 condition |
| TBX5T-box transcription factor 5 | Sometimes (5–29%) | In 1 condition |
| TRPM3transient receptor potential cation channel subfamily M member 3 | Sometimes (5–29%) | In 1 condition |
| ADNPactivity dependent neuroprotector homeobox | Rarely (1–4%) | In 1 condition |
| ALX4ALX homeobox 4 | Rarely (1–4%) | In 1 condition |
| GJA5gap junction protein alpha 5 | Rarely (1–4%) | In 1 condition |
| GJA8gap junction protein alpha 8 | Rarely (1–4%) | In 1 condition |
| MSX2msh homeobox 2 | Rarely (1–4%) | In 1 condition |
| COL2A1collagen type II alpha 1 chain | Not recorded | In 1 condition |
| EEDembryonic ectoderm development | Not recorded | In 1 condition |
| G6PC3glucose-6-phosphatase catalytic subunit 3 | Not recorded | In 1 condition |
| MEIS2Meis homeobox 2 | Not recorded | In 1 condition |
| RLIMring finger protein, LIM domain interacting | Not recorded | In 1 condition |
| WNT5AWnt family member 5A | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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