Trait

Delayed cranial suture closure

Infants normally have two fontanels at birth, the diamond-shaped anterior fontanelle at the junction of the coronal and sagittal sutures, and the posterior fontanelle at the intersection of the occipital and parietal bones. The posterior fontanelle usually closes by the 8th week of life, and the anterior fontanel closes by the 18th month of life on average. This term applies if there is delay of closure of the fontanelles beyond the normal age.

HPO HP:0000270

Also called: Broad late closing cranial sutures, Delayed closure of fontanel, Delayed closure of fontanelles, Delayed closure of fontanels, Delayed closure of the fontanelles, Delayed fontanel closure, Delayed fontanelle closure, Late closing fontanelles, Late closure of fontanelle, Late-closing fontanelle, Open sutures
Body system: Abnormality of head or neck Abnormality of the musculoskeletal system

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69 genes linked to Delayed cranial suture closure

Changes in these genes cause rare conditions in which Delayed cranial suture closure is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
GINS3GINS complex subunit 3	Always	In 1 condition
LMNAlamin A/C	Always	In 1 condition
PTDSS1phosphatidylserine synthase 1	Always	In 2 conditions
ZMPSTE24zinc metallopeptidase STE24	Always	In 1 condition
ATP7AATPase copper transporting alpha	Very often (80–99%)	In 1 condition
FAM111AFAM111 trypsin like peptidase A	Very often (80–99%)	In 1 condition
FAM20CFAM20C golgi associated secretory pathway kinase	Very often (80–99%)	In 1 condition
FLNAfilamin A	Very often (80–99%)	In 2 conditions
RNU12RNA, U12 small nuclear	Very often (80–99%)	In 2 conditions
ACTBactin beta	Often (30–79%)	In 1 condition
ACTG1actin gamma 1	Often (30–79%)	In 1 condition
ALDH18A1aldehyde dehydrogenase 18 family member A1	Often (30–79%)	In 2 conditions
AMER1APC membrane recruitment protein 1	Often (30–79%)	In 1 condition
CASZ1castor zinc finger 1	Often (30–79%)	In 1 condition
CTNNB1catenin beta 1	Often (30–79%)	In 1 condition
CTSKcathepsin K	Often (30–79%)	In 1 condition
DUOX2dual oxidase 2	Often (30–79%)	In 1 condition
DUOXA2dual oxidase maturation factor 2	Often (30–79%)	In 1 condition
FGFR2fibroblast growth factor receptor 2	Often (30–79%)	In 3 conditions
FGFR3fibroblast growth factor receptor 3	Often (30–79%)	In 1 condition
GABRDgamma-aminobutyric acid type A receptor subunit delta	Often (30–79%)	In 1 condition
HESX1HESX homeobox 1	Often (30–79%)	In 1 condition
HSD17B4hydroxysteroid 17-beta dehydrogenase 4	Often (30–79%)	In 1 condition
HSPG2heparan sulfate proteoglycan 2	Often (30–79%)	In 1 condition
IYDiodotyrosine deiodinase	Often (30–79%)	In 1 condition
KCNAB2potassium voltage-gated channel subfamily A regulatory beta subunit 2	Often (30–79%)	In 1 condition
LHX3LIM homeobox 3	Often (30–79%)	In 1 condition
LHX4LIM homeobox 4	Often (30–79%)	In 1 condition
LUZP1leucine zipper protein 1	Often (30–79%)	In 1 condition
MMP23Bmatrix metallopeptidase 23B	Often (30–79%)	In 1 condition
MTX2metaxin 2	Often (30–79%)	In 1 condition
NAA10N-alpha-acetyltransferase 10, NatA catalytic subunit	Often (30–79%)	In 2 conditions
PDPNpodoplanin	Often (30–79%)	In 1 condition
POU1F1POU class 1 homeobox 1	Often (30–79%)	In 2 conditions
PRDM16PR/SET domain 16	Often (30–79%)	In 1 condition
PRIM1DNA primase subunit 1	Often (30–79%)	In 1 condition
PRKCZprotein kinase C zeta	Often (30–79%)	In 1 condition
PROP1PROP paired-like homeobox 1	Often (30–79%)	In 1 condition
REREarginine-glutamic acid dipeptide repeats	Often (30–79%)	In 1 condition
SKISKI proto-oncogene	Often (30–79%)	In 1 condition

Show 29 more genes

Gene	How often it is seen	Conditions
SLC5A5solute carrier family 5 member 5	Often (30–79%)	In 1 condition
SPENspen family transcriptional repressor	Often (30–79%)	In 1 condition
TBCEtubulin folding cofactor E	Often (30–79%)	In 1 condition
TGthyroglobulin	Often (30–79%)	In 1 condition
TPOthyroid peroxidase	Often (30–79%)	In 1 condition
TSHBthyroid stimulating hormone subunit beta	Often (30–79%)	In 1 condition
TWIST1twist family bHLH transcription factor 1	Often (30–79%)	In 2 conditions
UBE4Bubiquitination factor E4B	Often (30–79%)	In 1 condition
ALG9ALG9 alpha-1,2-mannosyltransferase	Sometimes (5–29%)	In 1 condition
BICRABRD4 interacting chromatin remodeling complex associated protein	Sometimes (5–29%)	In 1 condition
DDX6DEAD-box helicase 6	Sometimes (5–29%)	In 1 condition
ELNelastin	Sometimes (5–29%)	In 1 condition
FBLN5fibulin 5	Sometimes (5–29%)	In 1 condition
GLI3GLI family zinc finger 3	Sometimes (5–29%)	In 1 condition
MAFMAF bZIP transcription factor	Sometimes (5–29%)	In 2 conditions
PPP1R21protein phosphatase 1 regulatory subunit 21	Sometimes (5–29%)	In 1 condition
RNF125ring finger protein 125	Sometimes (5–29%)	In 1 condition
USP7ubiquitin specific peptidase 7	Sometimes (5–29%)	In 1 condition
ZIC1Zic family zinc finger 1	Sometimes (5–29%)	In 1 condition
ATP6V0A2ATPase H+ transporting V0 subunit a2	Not recorded	In 1 condition
CHST14carbohydrate sulfotransferase 14	Not recorded	In 1 condition
CREBBPCREB binding lysine acetyltransferase	Not recorded	In 1 condition
CRTAPcartilage associated protein	Not recorded	In 1 condition
EP300EP300 lysine acetyltransferase	Not recorded	In 1 condition
IGF2insulin like growth factor 2	Not recorded	In 1 condition
PDGFRBplatelet derived growth factor receptor beta	Not recorded	In 1 condition
ROR2ROR family WNT receptor 2	Not recorded	In 2 conditions
RPS19ribosomal protein S19	Not recorded	In 1 condition
SH3PXD2BSH3 and PX domains 2B	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Delayed closure of the soft spot on the skull28 genes

Broader traits

Abnormality of cranial sutures

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.17-8666dff2.

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