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Gene

GNB2

G protein subunit beta 2

Summary

Cytogenetic location
7q22.1
Coordinates
Chromosome 7: 100,673,740–100,679,169 (GRCh38)
Exons
10 exons across 5.4 kb
Protein
340 amino acids
MANE Select transcript
ENST00000303210.9NM_005273.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads GNB2 yet. The test sequences your whole genome, so your data includes it all the same.

How GNB2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 7, with a bracket where GNB2 sits. GNB2 and 41 genes near it on chromosome 7, from 100,176,455 to 101,176,454.Chromosome 77q22.1p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.3100.2 Mb100.4 Mb100.6 Mb100.8 Mb101 MbGPC2: 100,169,602–100,177,389, reverse strandGPC2STAG3: 100,177,563–100,214,387, forward strandSTAG3: 100,205,357–100,221,488, forward strandPVRIG: 100,218,241–100,221,490, forward strandPVRIGSPDYE3: 100,307,702–100,322,372, forward strandSPDYE3PILRB: 100,351,627–100,367,831, forward strandPILRBPILRA: 100,367,530–100,400,098, forward strand: 100,397,577–100,434,107, forward strandZCWPW1: 100,400,826–100,428,992, reverse strandMEPCE: 100,428,322–100,435,138, forward strandMEPCEPPP1R35: 100,435,261–100,436,546, reverse strandPPP1R35SPACDR: 100,456,620–100,464,277, reverse strandSPACDRTSC22D4: 100,466,508–100,479,257, reverse strandTSC22D4: 100,478,099–100,478,170, reverse strandNYAP1: 100,483,605–100,494,802, forward strandNYAP1AGFG2: 100,539,169–100,569,429, forward strandAGFG2SAP25: 100,572,228–100,573,916, reverse strandLRCH4: 100,574,011–100,586,236, reverse strandLRCH4FBXO24: 100,583,982–100,601,117, forward strandPCOLCE: 100,602,321–100,608,175, forward strandPCOLCEMOSPD3: 100,612,102–100,616,004, forward strandMOSPD3TFR2: 100,620,416–100,642,779, reverse strandTFR2ACTL6B: 100,643,097–100,656,458, reverse strandACTL6BGNB2: 100,673,740–100,679,169, forward strandGNB2GIGYF1: 100,679,505–100,694,481, reverse strandGIGYF1POP7: 100,695,902–100,708,628, forward strandPOP7EPO: 100,720,465–100,723,700, forward strandEPOZAN: 100,733,595–100,797,797, forward strandZANEPHB4: 100,802,563–100,827,584, reverse strandEPHB4SLC12A9: 100,826,820–100,867,017, forward strandSLC12A9TRIP6: 100,867,126–100,873,524, forward strandTRIP6SRRT: 100,875,065–100,888,664, forward strandSRRTUFSP1: 100,888,721–100,889,715, reverse strandUFSP1ACHE: 100,889,993–100,897,022, reverse strandMUC3A: 100,949,414–100,968,348, forward strandMUC3AMUC12: 100,969,431–101,018,940, forward strandMUC12MUC17: 101,020,072–101,058,859, forward strandMUC17TRIM56: 101,085,234–101,097,967, forward strandTRIM56SERPINE1: 101,122,158–101,139,263, forward strandSERPINE1AP1S1: 101,154,352–101,161,596, forward strandAP1S1VGF: 101,162,509–101,167,245, reverse strandVGFNAT16: 101,170,496–101,180,301, reverse strandNAT16Diagram of GNB2: 10 exons on the forward strand of chromosome 7Exon 5: 4 known disease-causing sitesExon 6: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 1: 100,673,740–100,673,923, 184 basesExon 2: 100,676,177–100,676,322, 146 basesExon 3: 100,676,535–100,676,573, 39 basesExon 4: 100,676,693–100,676,799, 107 basesExon 5: 100,677,352–100,677,415, 64 basesExon 6: 100,677,498–100,677,660, 163 basesExon 7: 100,677,752–100,677,818, 67 basesExon 8: 100,678,098–100,678,299, 202 basesExon 9: 100,678,398–100,678,614, 217 basesExon 10: 100,678,695–100,679,169, 475 bases123456789105′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.7 kb of the gene's 5.4 kb; 1,023 of those bases code for the protein.

How a genome test reads GNB2

6

positions in GNB2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 5.4 kb of GNB2, introns included, not only the 1.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). GNB2 gene: G protein subunit beta 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/gnb2

Vancouver

Dante Labs. GNB2 gene: G protein subunit beta 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/gnb2

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