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Gene

PLCB4

phospholipase C beta 4

Summary

Cytogenetic location
20p12.3-p12.2
Coordinates
Chromosome 20: 9,069,087–9,480,808 (GRCh38)
Exons
40 exons across 411.7 kb
Protein
1,206 amino acids
MANE Select transcript
ENST00000378473.9NM_001377142.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PLCB4 yet. The test sequences your whole genome, so your data includes it all the same.

How PLCB4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 20, with a bracket where PLCB4 sits. PLCB4 and 3 genes near it on chromosome 20, from 8,657,365 to 9,892,530.Chromosome 2020p12.3-p12.2p13p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12q13.11q13.12q13.13q13.2q13.31q13.32q13.338.8 Mb9 Mb9.2 Mb9.4 Mb9.6 Mb9.8 MbPLCB1: 8,077,251–8,968,360, forward strandPLCB1PLCB4: 9,069,087–9,480,808, forward strandPLCB4LAMP5: 9,514,267–9,530,541, forward strandLAMP5PAK5: 9,537,370–9,839,076, reverse strandPAK5Diagram of PLCB4: 40 exons on the forward strand of chromosome 20Exon 14: 3 known disease-causing sitesExon 15: 2 known disease-causing sitesExon 22: 3 known disease-causing sitesExon 24: 5 known disease-causing sitesExon 1: 9,069,087–9,069,206, 120 basesExon 2: 9,096,287–9,096,342, 56 basesExon 3: 9,217,390–9,217,452, 63 basesExon 4: 9,307,800–9,307,898, 99 basesExon 5: 9,337,126–9,337,206, 81 basesExon 6: 9,338,008–9,338,067, 60 basesExon 7: 9,338,894–9,339,037, 144 basesExon 8: 9,362,896–9,362,975, 80 basesExon 9: 9,365,461–9,365,514, 54 basesExon 10: 9,371,214–9,371,295, 82 basesExon 11: 9,372,303–9,372,403, 101 basesExon 12: 9,373,047–9,373,104, 58 basesExon 13: 9,380,054–9,380,162, 109 basesExon 14: 9,384,201–9,384,411, 211 basesExon 15: 9,387,463–9,387,556, 94 basesExon 16: 9,389,879–9,389,958, 80 basesExon 17: 9,390,531–9,390,615, 85 basesExon 18: 9,393,588–9,393,678, 91 basesExon 19: 9,395,523–9,395,618, 96 basesExon 20: 9,401,490–9,401,590, 101 basesExon 21: 9,405,313–9,405,348, 36 basesExon 22: 9,407,917–9,408,058, 142 basesExon 23: 9,408,633–9,408,717, 85 basesExon 24: 9,409,057–9,409,181, 125 basesExon 25: 9,411,037–9,411,088, 52 basesExon 26: 9,419,807–9,419,909, 103 basesExon 27: 9,421,297–9,421,461, 165 basesExon 28: 9,423,748–9,423,952, 205 basesExon 29: 9,435,560–9,435,648, 89 basesExon 30: 9,437,002–9,437,152, 151 basesExon 31: 9,443,981–9,444,030, 50 basesExon 32: 9,444,178–9,444,243, 66 basesExon 33: 9,453,347–9,453,462, 116 basesExon 34: 9,457,414–9,457,489, 76 basesExon 35: 9,459,635–9,459,810, 176 basesExon 36: 9,468,571–9,468,672, 102 basesExon 37: 9,472,790–9,472,847, 58 basesExon 38: 9,473,279–9,473,365, 87 basesExon 39: 9,476,717–9,476,753, 37 basesExon 40: 9,478,921–9,480,808, 1,888 bases15101520253035405′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.7 kb of the gene's 411.7 kb; 3,621 of those bases code for the protein.

How a genome test reads PLCB4

14

positions in PLCB4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 411.7 kb of PLCB4, introns included, not only the 5.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PLCB4 gene: phospholipase C beta 4. Retrieved 16 October 2026, from https://dantelabs.com/genes/plcb4

Vancouver

Dante Labs. PLCB4 gene: phospholipase C beta 4 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/plcb4

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