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Gene

AKT3

AKT serine/threonine kinase 3

Summary

Cytogenetic location
1q43-q44
Coordinates
Chromosome 1: 243,499,724–243,850,243 (GRCh38)
Exons
14 exons across 350.5 kb
Protein
479 amino acids
Also known as
PKBG, RAC-gamma, PRKBG
MANE Select transcript
ENST00000673466.1NM_005465.7
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads AKT3 yet. The test sequences your whole genome, so your data includes it all the same.

How AKT3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where AKT3 sits. AKT3 and 3 genes near it on chromosome 1, from 243,149,204 to 244,200,763.Chromosome 11q43-q44p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44243.2 Mb243.4 Mb243.6 Mb243.8 Mb244 Mb244.2 MbCEP170: 243,123,977–243,255,793, reverse strandCEP170SDCCAG8: 243,255,349–243,517,961, forward strandSDCCAG8AKT3: 243,499,724–243,850,243, reverse strandAKT3ZBTB18: 244,048,547–244,057,476, forward strandZBTB18Diagram of AKT3: 14 exons on the reverse strand of chromosome 1Exon 14: 1 known disease-causing siteExon 13: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 8: 2 known disease-causing sitesExon 6: 2 known disease-causing sitesExon 4: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 14: 243,499,724–243,505,334, 5,611 basesExon 13: 243,512,324–243,512,426, 103 basesExon 12: 243,545,510–243,545,597, 88 basesExon 11: 243,552,729–243,552,943, 215 basesExon 10: 243,563,720–243,563,848, 129 basesExon 9: 243,572,926–243,573,048, 123 basesExon 8: 243,613,671–243,613,739, 69 basesExon 7: 243,615,096–243,615,161, 66 basesExon 6: 243,637,611–243,637,742, 132 basesExon 5: 243,645,893–243,646,037, 145 basesExon 4: 243,664,772–243,664,883, 112 basesExon 3: 243,695,591–243,695,716, 126 basesExon 2: 243,843,125–243,843,282, 158 basesExon 1: 243,850,040–243,850,243, 204 bases141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.3 kb of the gene's 350.5 kb; 1,440 of those bases code for the protein.

How a genome test reads AKT3

9

positions in AKT3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 350.5 kb of AKT3, introns included, not only the 7.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). AKT3 gene: AKT serine/threonine kinase 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/akt3

Vancouver

Dante Labs. AKT3 gene: AKT serine/threonine kinase 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/akt3

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