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Gene

IARS2

isoleucyl-tRNA synthetase 2, mitochondrial

Summary

Cytogenetic location
1q41
Coordinates
Chromosome 1: 220,094,132–220,148,041 (GRCh38)
Exons
23 exons across 53.9 kb
Protein
1,012 amino acids
Also known as
FLJ10326
MANE Select transcript
ENST00000366922.3NM_018060.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads IARS2 yet. The test sequences your whole genome, so your data includes it all the same.

How IARS2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where IARS2 sits. IARS2 and 5 genes near it on chromosome 1, from 219,621,087 to 220,621,086.Chromosome 11q41p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44219.8 Mb220 Mb220.2 Mb220.4 Mb220.6 MbSLC30A10: 219,685,427–219,959,018, reverse strandSLC30A10EPRS1: 219,968,598–220,046,669, reverse strandEPRS1BPNT1: 220,057,079–220,119,267, reverse strandBPNT1IARS2: 220,094,132–220,148,041, forward strandIARS2RAB3GAP2: 220,148,293–220,272,529, reverse strandRAB3GAP2MARK1: 220,528,086–220,664,461, forward strandMARK1Diagram of IARS2: 23 exons on the forward strand of chromosome 1Exon 2: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 15: 1 known disease-causing siteExon 19: 1 known disease-causing siteExon 20: 1 known disease-causing siteExon 21: 1 known disease-causing siteExon 1: 220,094,132–220,094,483, 352 basesExon 2: 220,096,104–220,096,226, 123 basesExon 3: 220,100,490–220,100,649, 160 basesExon 4: 220,102,129–220,102,277, 149 basesExon 5: 220,102,363–220,102,412, 50 basesExon 6: 220,102,495–220,102,604, 110 basesExon 7: 220,102,687–220,102,777, 91 basesExon 8: 220,103,447–220,103,562, 116 basesExon 9: 220,105,891–220,106,060, 170 basesExon 10: 220,107,061–220,107,151, 91 basesExon 11: 220,110,786–220,110,937, 152 basesExon 12: 220,114,314–220,114,474, 161 basesExon 13: 220,125,237–220,125,339, 103 basesExon 14: 220,126,750–220,126,843, 94 basesExon 15: 220,134,402–220,134,510, 109 basesExon 16: 220,136,809–220,136,911, 103 basesExon 17: 220,137,918–220,138,043, 126 basesExon 18: 220,139,008–220,139,139, 132 basesExon 19: 220,140,183–220,140,289, 107 basesExon 20: 220,141,803–220,141,948, 146 basesExon 21: 220,142,944–220,143,134, 191 basesExon 22: 220,145,509–220,145,653, 145 basesExon 23: 220,147,493–220,148,041, 549 bases15101520235′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.5 kb of the gene's 53.9 kb; 3,039 of those bases code for the protein.

How a genome test reads IARS2

6

positions in IARS2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 53.9 kb of IARS2, introns included, not only the 3.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). IARS2 gene: isoleucyl-tRNA synthetase 2, mitochondrial. Retrieved 17 October 2026, from https://dantelabs.com/genes/iars2

Vancouver

Dante Labs. IARS2 gene: isoleucyl-tRNA synthetase 2, mitochondrial [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/iars2

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