Gene
CHRNG
cholinergic receptor nicotinic gamma subunit
- HGNC 1967(opens in a new tab)
- Ensembl gene ENSG00000196811(opens in a new tab)
- NCBI Gene 1146(opens in a new tab)
Summary
- Cytogenetic location
- 2q37.1
- Coordinates
- Chromosome 2: 232,539,692–232,548,115 (GRCh38)
- Exons
- 12 exons across 8.4 kb
- Protein
- 517 amino acids
- Previous symbols
- ACHRG
- MANE Select transcript
- ENST00000651502.1NM_005199.5
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read CHRNG, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome TestCurated report relevant to this gene
Autoimmune Disease
A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to their own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis).
- 1 GenCC submitter rates it definitive or strong
How CHRNG is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 4 kb of the gene's 8.4 kb; 1,554 of those bases code for the protein.
How a genome test reads CHRNG
54
positions in CHRNG where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 8.4 kb of CHRNG, introns included, not only the 4 kb of exons.
Traits linked to CHRNG
The Human Phenotype Ontology lists these as features of the rare conditions CHRNG can cause. Each trait's page lists the other genes linked to it.
Abnormality of head or neck
- Downturned corners of mouth
- Downward slanting of the opening between the eyelids
- High palate
- Webbed neck
- Abnormality of the eyelid
- Abnormally small head
- Bad bite
- Cleft of the mouth
Show 18 more traits
- Corners of eye widely separated
- Eye folds
- Facial asymmetry
- Little lower jaw
- Long face
- Narrow mouth
- Pointed chin
- Short neck
- Triangular mouth
- Weakness of facial musculature
- Abnormality of the tongue
- Cleft palate
- Long philtrum
- Long, narrow head
- Low hairline at back of neck
- Abnormal facial shape
- Cystic hygroma
- Flat nose
Abnormality of the musculoskeletal system
- Arthrogryposis multiplex congenita
- Permanent flexion of the finger or toe
- Abnormality of the sternum
- Funnel chest
- Limitation of joint mobility
- Scoliosis
- Abnormally shaped skeletal
- Flexed joint that cannot be straightened
Show 18 more traits
- Hunched back
- Multiple joint contractures
- Rounded shoulders
- Thoracolumbar scoliosis
- Vertebral segmentation defect
- Muscle degeneration
- Rib fusion
- Abnormal neck curve
- Absent muscles since birth
- Anterior clefting of vertebral bodies
- Congenital diaphragmatic hernia
- Diaphragmatic eventration
- Fused neck
- Increased susceptibility to fractures
- Joint dislocation
- Long collarbone
- Thin ribs
- Vertebral fusion
Abnormality of the integument
- Pterygium
- Antecubital pterygium
- Axillary pterygium
- Multiple pterygia
- Popliteal pterygium
- Absent/small skin
- Mole
- Intercrural pterygium
Show 1 more trait
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). CHRNG gene: cholinergic receptor nicotinic gamma subunit. Retrieved 16 October 2026, from https://dantelabs.com/genes/chrng
Dante Labs. CHRNG gene: cholinergic receptor nicotinic gamma subunit [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/chrng
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks