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Gene

TRIP4

thyroid hormone receptor interactor 4

Summary

Cytogenetic location
15q22.31
Coordinates
Chromosome 15: 64,387,836–64,455,303 (GRCh38)
Exons
13 exons across 67.5 kb
Protein
581 amino acids
Also known as
HsT17391, ZC2HC5, ASC-1
MANE Select transcript
ENST00000261884.8NM_016213.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Congenital Muscular Dystrophies

    • Congenital muscular dystrophy

      A group of muscular dystrophies with onset at birth or in infancy, including dystroglycanopathies (such as FKRP, FKTN and POMT1/2-related forms).

      • 1 GenCC submitter rates it definitive or strong

How TRIP4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 15, with a bracket where TRIP4 sits. TRIP4 and 15 genes near it on chromosome 15, from 63,921,570 to 64,921,569.Chromosome 1515q22.31p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.364 Mb64.2 Mb64.4 Mb64.6 Mb64.8 MbDAPK2: 63,907,033–64,072,033, reverse strandDAPK2CIAO2A: 64,072,113–64,094,262, reverse strandCIAO2ASNX1: 64,094,123–64,146,571, forward strandSNX1SNX22: 64,151,601–64,157,481, forward strandSNX22PPIB: 64,155,740–64,163,159, reverse strandPPIBCSNK1G1: 64,165,525–64,356,554, reverse strandCSNK1G1: 64,181,180–64,381,440, reverse strandPCLAF: 64,364,129–64,387,687, reverse strandPCLAFTRIP4: 64,387,836–64,455,303, forward strandTRIP4ZNF609: 64,460,549–64,686,068, forward strandZNF609OAZ2: 64,686,833–64,703,281, reverse strandOAZ2RBPMS2: 64,739,886–64,775,860, reverse strandRBPMS2PIF1: 64,815,629–64,825,677, reverse strandPIF1PLEKHO2: 64,839,231–64,868,002, forward strandPLEKHO2: 64,841,883–64,930,920, forward strandANKDD1A: 64,911,853–64,979,845, forward strandANKDD1ADiagram of TRIP4: 13 exons on the forward strand of chromosome 15Exon 2: 3 known disease-causing sitesExon 3: 1 known disease-causing siteExon 7: 3 known disease-causing sitesExon 1: 64,387,836–64,387,964, 129 basesExon 2: 64,393,946–64,394,115, 170 basesExon 3: 64,395,398–64,395,531, 134 basesExon 4: 64,397,606–64,397,818, 213 basesExon 5: 64,400,743–64,400,821, 79 basesExon 6: 64,406,330–64,406,459, 130 basesExon 7: 64,409,613–64,409,828, 216 basesExon 8: 64,414,085–64,414,211, 127 basesExon 9: 64,418,541–64,418,728, 188 basesExon 10: 64,424,031–64,424,155, 125 basesExon 11: 64,425,540–64,425,631, 92 basesExon 12: 64,445,006–64,445,108, 103 basesExon 13: 64,454,997–64,455,303, 307 bases124681012135′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2 kb of the gene's 67.5 kb; 1,746 of those bases code for the protein.

How a genome test reads TRIP4

9

positions in TRIP4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 67.5 kb of TRIP4, introns included, not only the 2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TRIP4 gene: thyroid hormone receptor interactor 4. Retrieved 17 October 2026, from https://dantelabs.com/genes/trip4

Vancouver

Dante Labs. TRIP4 gene: thyroid hormone receptor interactor 4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/trip4

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