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Gene

RIPK4

receptor interacting serine/threonine kinase 4

Summary

Cytogenetic location
21q22.3
Coordinates
Chromosome 21: 41,739,373–41,767,052 (GRCh38)
Exons
8 exons across 27.7 kb
Protein
784 amino acids
Also known as
DIK, ANKK2, RIP4, PKK
Previous symbols
ANKRD3
MANE Select transcript
ENST00000332512.8NM_020639.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads RIPK4 yet. The test sequences your whole genome, so your data includes it all the same.

How RIPK4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 21, with a bracket where RIPK4 sits. RIPK4 and 10 genes near it on chromosome 21, from 41,253,213 to 42,253,212.Chromosome 2121q22.3p13p12p11.2p11.1q11.1q11.2q21.1q21.2q21.3q22.11q22.12q22.13q22.2q22.341.4 Mb41.6 Mb41.8 Mb42 Mb42.2 MbBACE2: 41,167,775–41,282,530, forward strandBACE2FAM3B: 41,304,212–41,358,091, forward strandFAM3BMX2: 41,361,957–41,409,420, forward strandMX2MX1: 41,420,020–41,470,071, forward strandMX1TMPRSS2: 41,464,296–41,531,116, reverse strandTMPRSS2RIPK4: 41,739,373–41,767,052, reverse strandRIPK4PRDM15: 41,798,225–41,879,482, reverse strandPRDM15C2CD2: 41,885,111–41,954,022, reverse strandC2CD2ZBTB21: 41,986,293–42,010,387, reverse strandZBTB21UMODL1: 42,062,959–42,143,453, forward strandUMODL1ABCG1: 42,199,689–42,304,389, forward strandABCG1Diagram of RIPK4: 8 exons on the reverse strand of chromosome 21Exon 5: 1 known disease-causing siteExon 8: 41,739,373–41,741,997, 2,625 basesExon 7: 41,743,882–41,744,140, 259 basesExon 6: 41,745,759–41,745,862, 104 basesExon 5: 41,746,613–41,746,771, 159 basesExon 4: 41,749,154–41,749,203, 50 basesExon 3: 41,751,097–41,751,245, 149 basesExon 2: 41,756,525–41,756,816, 292 basesExon 1: 41,766,860–41,767,052, 193 bases876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.8 kb of the gene's 27.7 kb; 2,355 of those bases code for the protein.

How a genome test reads RIPK4

1

position in RIPK4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 27.7 kb of RIPK4, introns included, not only the 3.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RIPK4 gene: receptor interacting serine/threonine kinase 4. Retrieved 17 October 2026, from https://dantelabs.com/genes/ripk4

Vancouver

Dante Labs. RIPK4 gene: receptor interacting serine/threonine kinase 4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ripk4

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