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Gene

NEDD4L

NEDD4 like E3 ubiquitin protein ligase

Summary

Cytogenetic location
18q21.31
Coordinates
Chromosome 18: 58,044,226–58,401,539 (GRCh38)
Exons
31 exons across 357.3 kb
Protein
975 amino acids
Also known as
KIAA0439, RSP5, NEDD4-2
MANE Select transcript
ENST00000400345.8NM_001144967.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads NEDD4L yet. The test sequences your whole genome, so your data includes it all the same.

How NEDD4L is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 18, with a bracket where NEDD4L sits. NEDD4L and 3 genes near it on chromosome 18, from 57,686,912 to 58,758,853.Chromosome 1818q21.31p11.32p11.31p11.23p11.22p11.21p11.1q11.1q11.2q12.1q12.2q12.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q2357.8 Mb58 Mb58.2 Mb58.4 Mb58.6 MbATP8B1: 57,646,426–57,803,560, reverse strandATP8B1NEDD4L: 58,044,226–58,401,539, forward strandNEDD4LALPK2: 58,481,241–58,629,247, reverse strandALPK2MALT1: 58,671,426–58,754,477, forward strandMALT1Diagram of NEDD4L: 31 exons on the forward strand of chromosome 18Exon 9: 1 known disease-causing siteExon 21: 1 known disease-causing siteExon 23: 1 known disease-causing siteExon 29: 1 known disease-causing siteExon 1: 58,044,226–58,044,708, 483 basesExon 2: 58,165,788–58,165,861, 74 basesExon 3: 58,245,427–58,245,508, 82 basesExon 4: 58,248,899–58,248,937, 39 basesExon 5: 58,252,001–58,252,054, 54 basesExon 6: 58,315,982–58,316,032, 51 basesExon 7: 58,322,425–58,322,486, 62 basesExon 8: 58,323,232–58,323,334, 103 basesExon 9: 58,324,996–58,325,162, 167 basesExon 10: 58,328,995–58,329,127, 133 basesExon 11: 58,330,738–58,330,914, 177 basesExon 12: 58,333,818–58,333,892, 75 basesExon 13: 58,335,478–58,335,537, 60 basesExon 14: 58,341,038–58,341,169, 132 basesExon 15: 58,341,678–58,341,797, 120 basesExon 16: 58,342,906–58,343,103, 198 basesExon 17: 58,349,537–58,349,614, 78 basesExon 18: 58,350,991–58,351,045, 55 basesExon 19: 58,357,194–58,357,252, 59 basesExon 20: 58,364,268–58,364,333, 66 basesExon 21: 58,365,999–58,366,228, 230 basesExon 22: 58,367,746–58,367,867, 122 basesExon 23: 58,370,397–58,370,467, 71 basesExon 24: 58,373,174–58,373,269, 96 basesExon 25: 58,383,246–58,383,319, 74 basesExon 26: 58,385,526–58,385,586, 61 basesExon 27: 58,387,439–58,387,498, 60 basesExon 28: 58,389,085–58,389,192, 108 basesExon 29: 58,390,646–58,390,742, 97 basesExon 30: 58,391,487–58,391,559, 73 basesExon 31: 58,396,167–58,401,539, 5,373 bases120315′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 8.6 kb of the gene's 357.3 kb; 2,928 of those bases code for the protein.

How a genome test reads NEDD4L

6

positions in NEDD4L where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 357.3 kb of NEDD4L, introns included, not only the 8.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NEDD4L gene: NEDD4 like E3 ubiquitin protein ligase. Retrieved 17 October 2026, from https://dantelabs.com/genes/nedd4l

Vancouver

Dante Labs. NEDD4L gene: NEDD4 like E3 ubiquitin protein ligase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/nedd4l

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