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Gene

ORC4

origin recognition complex subunit 4

Summary

Cytogenetic location
2q23.1
Coordinates
Chromosome 2: 147,930,396–148,020,737 (GRCh38)
Exons
14 exons across 90.3 kb
Protein
436 amino acids
Also known as
HsORC4, Orc4p
Previous symbols
ORC4L
MANE Select transcript
ENST00000392857.10NM_181741.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads ORC4 yet. The test sequences your whole genome, so your data includes it all the same.

How ORC4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where ORC4 sits. ORC4 and 2 genes near it on chromosome 2, from 147,475,567 to 148,475,566.Chromosome 22q23.1p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3147.6 Mb147.8 Mb148 Mb148.2 Mb148.4 MbACVR2A: 147,844,378–147,930,838, forward strandACVR2AORC4: 147,930,396–148,020,737, reverse strandORC4MBD5: 148,021,011–148,516,971, forward strandMBD5Diagram of ORC4: 14 exons on the reverse strand of chromosome 2Exon 14: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 14: 147,930,396–147,935,698, 5,303 basesExon 13: 147,938,146–147,938,213, 68 basesExon 12: 147,938,298–147,938,393, 96 basesExon 11: 147,939,140–147,939,248, 109 basesExon 10: 147,943,436–147,943,522, 87 basesExon 9: 147,948,051–147,948,224, 174 basesExon 8: 147,952,373–147,952,524, 152 basesExon 7: 147,955,347–147,955,395, 49 basesExon 6: 147,958,298–147,958,383, 86 basesExon 5: 147,958,791–147,958,866, 76 basesExon 4: 147,972,739–147,972,829, 91 basesExon 3: 147,973,448–147,973,524, 77 basesExon 2: 147,975,902–147,975,975, 74 basesExon 1: 148,020,633–148,020,737, 105 bases141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.5 kb of the gene's 90.3 kb; 1,311 of those bases code for the protein.

How a genome test reads ORC4

6

positions in ORC4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 90.3 kb of ORC4, introns included, not only the 6.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ORC4 gene: origin recognition complex subunit 4. Retrieved 16 October 2026, from https://dantelabs.com/genes/orc4

Vancouver

Dante Labs. ORC4 gene: origin recognition complex subunit 4 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/orc4

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