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Gene

MDM2

MDM2 proto-oncogene

Summary

Cytogenetic location
12q15
Coordinates
Chromosome 12: 68,808,177–68,845,544 (GRCh38)
Exons
11 exons across 37.4 kb
Protein
497 amino acids
Also known as
HDM2, MGC5370
MANE Select transcript
ENST00000258149.11NM_002392.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads MDM2 yet. The test sequences your whole genome, so your data includes it all the same.

How MDM2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 12, with a bracket where MDM2 sits. MDM2 and 6 genes near it on chromosome 12, from 68,326,861 to 69,326,860.Chromosome 1212q15p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3368.4 Mb68.6 Mb68.8 Mb69 Mb69.2 MbSAXO6: 68,272,443–68,332,396, reverse strandSAXO6RAP1B: 68,610,410–68,671,901, forward strandRAP1BNUP107: 68,686,951–68,745,809, forward strandNUP107SLC35E3: 68,746,080–68,793,974, forward strandSLC35E3MDM2: 68,808,177–68,845,544, forward strandMDM2CPM: 68,842,192–68,971,570, reverse strandCPMCPSF6: 69,239,543–69,279,829, forward strandCPSF6Diagram of MDM2: 11 exons on the forward strand of chromosome 12Exon 1: 68,808,177–68,808,491, 315 basesExon 2: 68,809,208–68,809,292, 85 basesExon 3: 68,813,554–68,813,628, 75 basesExon 4: 68,816,812–68,816,945, 134 basesExon 5: 68,820,325–68,820,374, 50 basesExon 6: 68,824,363–68,824,430, 68 basesExon 7: 68,824,555–68,824,651, 97 basesExon 8: 68,828,771–68,828,931, 161 basesExon 9: 68,835,829–68,835,984, 156 basesExon 10: 68,836,672–68,836,749, 78 basesExon 11: 68,839,274–68,845,544, 6,271 bases1246810115′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.5 kb of the gene's 37.4 kb; 1,494 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.

Cite this page

APA

Dante Labs. (n.d.). MDM2 gene: MDM2 proto-oncogene. Retrieved 17 October 2026, from https://dantelabs.com/genes/mdm2

Vancouver

Dante Labs. MDM2 gene: MDM2 proto-oncogene [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/mdm2

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