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Gene

CDC45

cell division cycle 45

Summary

Cytogenetic location
22q11.21
Coordinates
Chromosome 22: 19,479,920–19,520,608 (GRCh38)
Exons
19 exons across 40.7 kb
Protein
566 amino acids
Previous symbols
CDC45L2, CDC45L
MANE Select transcript
ENST00000263201.7NM_003504.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads CDC45 yet. The test sequences your whole genome, so your data includes it all the same.

How CDC45 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 22, with a bracket where CDC45 sits. CDC45 and 21 genes near it on chromosome 22, from 19,000,264 to 20,000,263.Chromosome 2222q11.21p13p12p11.2p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.31q13.32q13.3319.2 Mb19.4 Mb19.6 Mb19.8 Mb20 MbFAM246C: 19,029,524–19,031,242, forward strandFAM246CDGCR2: 19,036,280–19,122,461, reverse strandDGCR2ESS2: 19,130,279–19,144,684, reverse strandESS2TSSK2: 19,131,308–19,132,622, forward strandTSSK2GSC2: 19,146,993–19,150,292, reverse strandGSC2SLC25A1: 19,175,573–19,178,863, reverse strandSLC25A1CLTCL1: 19,179,319–19,291,774, reverse strandCLTCL1HIRA: 19,330,185–19,447,450, reverse strandHIRAC22orf39: 19,351,368–19,447,714, reverse strandC22orf39MRPL40: 19,431,837–19,436,078, forward strandMRPL40UFD1: 19,449,899–19,479,695, reverse strandUFD1CDC45: 19,479,920–19,520,608, forward strandCDC45CLDN5: 19,517,452–19,527,545, reverse strandCLDN5SEPTIN5: 19,714,117–19,724,781, forward strandSEPTIN5: 19,717,220–19,724,772, forward strandGP1BB: 19,723,539–19,724,776, forward strandGP1BBTBX1: 19,756,703–19,783,593, forward strandTBX1GNB1L: 19,781,243–19,854,947, reverse strandGNB1LRTL10: 19,846,138–19,854,939, reverse strandRTL10TXNRD2: 19,875,517–19,941,934, reverse strandTXNRD2COMT: 19,941,371–19,969,975, forward strandCOMTARVCF: 19,969,866–20,016,862, reverse strandARVCFDiagram of CDC45: 19 exons on the forward strand of chromosome 22Exon 1: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 7: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 15: 1 known disease-causing siteExon 16: 1 known disease-causing siteExon 18: 1 known disease-causing siteExon 1: 19,479,920–19,480,019, 100 basesExon 2: 19,480,158–19,480,217, 60 basesExon 3: 19,480,953–19,481,045, 93 basesExon 4: 19,482,690–19,482,827, 138 basesExon 5: 19,483,862–19,484,005, 144 basesExon 6: 19,494,327–19,494,382, 56 basesExon 7: 19,495,981–19,496,029, 49 basesExon 8: 19,497,386–19,497,447, 62 basesExon 9: 19,499,101–19,499,151, 51 basesExon 10: 19,505,362–19,505,481, 120 basesExon 11: 19,507,386–19,507,517, 132 basesExon 12: 19,507,766–19,507,864, 99 basesExon 13: 19,508,530–19,508,691, 162 basesExon 14: 19,514,749–19,514,887, 139 basesExon 15: 19,514,965–19,515,048, 84 basesExon 16: 19,516,527–19,516,645, 119 basesExon 17: 19,516,817–19,516,893, 77 basesExon 18: 19,518,844–19,518,909, 66 basesExon 19: 19,520,481–19,520,608, 128 bases151015195′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.9 kb of the gene's 40.7 kb; 1,701 of those bases code for the protein.

How a genome test reads CDC45

12

positions in CDC45 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 40.7 kb of CDC45, introns included, not only the 1.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CDC45 gene: cell division cycle 45. Retrieved 16 October 2026, from https://dantelabs.com/genes/cdc45

Vancouver

Dante Labs. CDC45 gene: cell division cycle 45 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cdc45

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