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Gene

LMX1B

LIM homeobox transcription factor 1 beta

Summary

Cytogenetic location
9q33.3
Coordinates
Chromosome 9: 126,613,928–126,701,032 (GRCh38)
Exons
8 exons across 87.1 kb
Protein
402 amino acids
Previous symbols
NPS1
MANE Select transcript
ENST00000373474.9NM_001174147.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads LMX1B yet. The test sequences your whole genome, so your data includes it all the same.

How LMX1B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 9, with a bracket where LMX1B sits. LMX1B and 5 genes near it on chromosome 9, from 126,157,480 to 127,157,479.Chromosome 99q33.3p24.3p24.2p24.1p23p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q13q21.11q21.12q21.13q21.2q21.31q21.32q21.33q22.1q22.2q22.31q22.32q22.33q31.1q31.2q31.3q32q33.1q33.2q33.3q34.11q34.12q34.13q34.2q34.3126.2 Mb126.4 Mb126.6 Mb126.8 Mb127 MbMVB12B: 126,326,494–126,507,047, forward strandMVB12BLMX1B: 126,613,928–126,701,032, forward strandLMX1BZBTB43: 126,804,988–126,838,210, forward strandZBTB43ZBTB34: 126,860,626–126,885,878, forward strandZBTB34RALGPS1: 126,914,761–127,223,166, forward strandRALGPS1ANGPTL2: 127,087,333–127,122,786, reverse strandANGPTL2Diagram of LMX1B: 8 exons on the forward strand of chromosome 9Exon 1: 2 known disease-causing sitesExon 2: 7 known disease-causing sitesExon 3: 5 known disease-causing sitesExon 4: 8 known disease-causing sitesExon 5: 11 known disease-causing sitesExon 7: 4 known disease-causing sitesExon 1: 126,613,928–126,614,588, 661 basesExon 2: 126,615,383–126,615,569, 187 basesExon 3: 126,690,836–126,691,068, 233 basesExon 4: 126,693,142–126,693,323, 182 basesExon 5: 126,693,524–126,693,601, 78 basesExon 6: 126,693,746–126,693,812, 67 basesExon 7: 126,695,839–126,696,003, 165 basesExon 8: 126,696,294–126,701,032, 4,739 bases1585′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.3 kb of the gene's 87.1 kb; 1,209 of those bases code for the protein.

How a genome test reads LMX1B

39

positions in LMX1B where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 87.1 kb of LMX1B, introns included, not only the 6.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LMX1B gene: LIM homeobox transcription factor 1 beta. Retrieved 17 October 2026, from https://dantelabs.com/genes/lmx1b

Vancouver

Dante Labs. LMX1B gene: LIM homeobox transcription factor 1 beta [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/lmx1b

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