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Gene

UBE3B

ubiquitin protein ligase E3B

Summary

Cytogenetic location
12q24.11
Coordinates
Chromosome 12: 109,477,634–109,536,702 (GRCh38)
Exons
28 exons across 59.1 kb
Protein
1,068 amino acids
MANE Select transcript
ENST00000342494.8NM_130466.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads UBE3B yet. The test sequences your whole genome, so your data includes it all the same.

How UBE3B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where UBE3B sits. UBE3B and 16 genes near it on chromosome 12, from 109,007,168 to 110,007,167.Chromosome 1212q24.11p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.33109.2 Mb109.4 Mb109.6 Mb109.8 Mb110 MbSVOP: 108,907,741–109,021,068, reverse strandSVOPUSP30: 109,023,089–109,088,023, forward strandUSP30ALKBH2: 109,085,154–109,098,462, reverse strandALKBH2UNG: 109,097,569–109,126,725, forward strandUNGACACB: 109,116,320–109,268,226, forward strandACACBFOXN4: 109,277,978–109,309,289, reverse strandFOXN4MYO1H: 109,347,900–109,455,523, forward strandMYO1HKCTD10: 109,448,655–109,477,359, reverse strandKCTD10UBE3B: 109,477,634–109,536,702, forward strandUBE3BMMAB: 109,553,715–109,573,580, reverse strandMMABMVK: 109,573,255–109,600,609, forward strandMVKFAM222A: 109,713,819–109,770,495, forward strandFAM222ATRPV4: 109,783,087–109,833,542, reverse strandTRPV4GLTP: 109,850,943–109,880,549, reverse strandGLTPTCHP: 109,900,264–109,983,841, forward strandTCHPGIT2: 109,929,792–109,996,389, reverse strandGIT2ANKRD13A: 109,999,186–110,039,763, forward strandANKRD13ADiagram of UBE3B: 28 exons on the forward strand of chromosome 12Exon 3: 2 known disease-causing sitesExon 6: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 10: 3 known disease-causing sitesExon 13: 3 known disease-causing sitesExon 15: 2 known disease-causing sitesExon 18: 1 known disease-causing siteExon 19: 2 known disease-causing sitesExon 20: 3 known disease-causing sitesExon 21: 1 known disease-causing siteExon 23: 1 known disease-causing siteExon 24: 1 known disease-causing siteExon 25: 1 known disease-causing siteExon 27: 1 known disease-causing siteExon 28: 1 known disease-causing siteExon 1: 109,477,634–109,478,109, 476 basesExon 2: 109,481,637–109,481,742, 106 basesExon 3: 109,483,531–109,483,712, 182 basesExon 4: 109,483,861–109,483,981, 121 basesExon 5: 109,486,012–109,486,071, 60 basesExon 6: 109,486,471–109,486,575, 105 basesExon 7: 109,488,572–109,488,668, 97 basesExon 8: 109,489,919–109,490,004, 86 basesExon 9: 109,491,045–109,491,127, 83 basesExon 10: 109,497,818–109,497,923, 106 basesExon 11: 109,498,233–109,498,353, 121 basesExon 12: 109,499,633–109,499,810, 178 basesExon 13: 109,501,371–109,501,534, 164 basesExon 14: 109,503,023–109,503,190, 168 basesExon 15: 109,507,564–109,507,735, 172 basesExon 16: 109,509,596–109,509,714, 119 basesExon 17: 109,510,344–109,510,458, 115 basesExon 18: 109,511,204–109,511,303, 100 basesExon 19: 109,516,765–109,516,884, 120 basesExon 20: 109,521,148–109,521,324, 177 basesExon 21: 109,521,441–109,521,551, 111 basesExon 22: 109,523,978–109,524,115, 138 basesExon 23: 109,524,438–109,524,503, 66 basesExon 24: 109,526,358–109,526,416, 59 basesExon 25: 109,529,890–109,530,072, 183 basesExon 26: 109,530,547–109,530,658, 112 basesExon 27: 109,533,466–109,533,558, 93 basesExon 28: 109,534,591–109,536,702, 2,112 bases12468101214161820222426285′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.7 kb of the gene's 59.1 kb; 3,207 of those bases code for the protein.

How a genome test reads UBE3B

35

positions in UBE3B where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 59.1 kb of UBE3B, introns included, not only the 5.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). UBE3B gene: ubiquitin protein ligase E3B. Retrieved 16 October 2026, from https://dantelabs.com/genes/ube3b

Vancouver

Dante Labs. UBE3B gene: ubiquitin protein ligase E3B [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/ube3b

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