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Gene

POU4F1

POU class 4 homeobox 1

Summary

Cytogenetic location
13q31.1
Coordinates
Chromosome 13: 78,598,362–78,603,552 (GRCh38)
Exons
2 exons across 5.2 kb
Protein
419 amino acids
Also known as
RDC-1
Previous symbols
BRN3A
MANE Select transcript
ENST00000377208.7NM_006237.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads POU4F1 yet. The test sequences your whole genome, so your data includes it all the same.

How POU4F1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 13, with a bracket where POU4F1 sits. POU4F1 and 1 gene near it on chromosome 13, from 78,100,957 to 79,100,956.Chromosome 1313q31.1p13p12p11.2p11.1q11q12.11q12.12q12.13q12.2q12.3q13.1q13.2q13.3q14.11q14.12q14.13q14.2q14.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q3478.2 Mb78.4 Mb78.6 Mb78.8 Mb79 MbPOU4F1: 78,598,362–78,603,552, reverse strandPOU4F1OBI1: 78,612,773–78,659,191, reverse strandOBI1Diagram of POU4F1: 2 exons on the reverse strand of chromosome 13Exon 2: 1 known disease-causing siteExon 1: 2 known disease-causing sitesExon 2: 78,598,362–78,602,551, 4,190 basesExon 1: 78,603,204–78,603,552, 349 bases215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.5 kb of the gene's 5.2 kb; 1,260 of those bases code for the protein.

How a genome test reads POU4F1

3

positions in POU4F1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 5.2 kb of POU4F1, introns included, not only the 4.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). POU4F1 gene: POU class 4 homeobox 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/pou4f1

Vancouver

Dante Labs. POU4F1 gene: POU class 4 homeobox 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/pou4f1

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