Skip to content
Use your HSA or FSA funds

Gene

TOP2B

DNA topoisomerase II beta

Summary

Cytogenetic location
3p24.2
Coordinates
Chromosome 3: 25,597,984–25,664,907 (GRCh38)
Exons
36 exons across 66.9 kb
Protein
1,626 amino acids
Also known as
top2beta, TOPIIB
MANE Select transcript
ENST00000264331.9NM_001330700.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TOP2B yet. The test sequences your whole genome, so your data includes it all the same.

How TOP2B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where TOP2B sits. TOP2B and 3 genes near it on chromosome 3, from 25,131,446 to 26,131,445.Chromosome 33p24.2p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q2925.2 Mb25.4 Mb25.6 Mb25.8 Mb26 MbRARB: 24,687,887–25,597,932, forward strandRARBTOP2B: 25,597,984–25,664,907, reverse strandTOP2BNGLY1: 25,718,698–25,790,039, reverse strandNGLY1OXSM: 25,782,917–25,797,141, forward strandOXSMDiagram of TOP2B: 36 exons on the reverse strand of chromosome 3Exon 26: 1 known disease-causing siteExon 36: 25,597,984–25,598,477, 494 basesExon 35: 25,599,435–25,599,529, 95 basesExon 34: 25,601,100–25,601,225, 126 basesExon 33: 25,604,760–25,604,870, 111 basesExon 32: 25,606,043–25,606,122, 80 basesExon 31: 25,607,171–25,607,375, 205 basesExon 30: 25,609,183–25,609,344, 162 basesExon 29: 25,609,568–25,609,712, 145 basesExon 28: 25,612,515–25,612,709, 195 basesExon 27: 25,615,205–25,615,288, 84 basesExon 26: 25,615,431–25,615,586, 156 basesExon 25: 25,618,418–25,618,509, 92 basesExon 24: 25,618,654–25,618,849, 196 basesExon 23: 25,619,862–25,620,062, 201 basesExon 22: 25,620,682–25,620,816, 135 basesExon 21: 25,623,515–25,623,746, 232 basesExon 20: 25,624,297–25,624,445, 149 basesExon 19: 25,624,682–25,624,803, 122 basesExon 18: 25,626,560–25,626,674, 115 basesExon 17: 25,626,772–25,626,864, 93 basesExon 16: 25,627,187–25,627,296, 110 basesExon 15: 25,628,847–25,628,952, 106 basesExon 14: 25,629,035–25,629,145, 111 basesExon 13: 25,630,029–25,630,154, 126 basesExon 12: 25,630,312–25,630,469, 158 basesExon 11: 25,630,801–25,630,939, 139 basesExon 10: 25,632,446–25,632,583, 138 basesExon 9: 25,632,693–25,632,794, 102 basesExon 8: 25,633,841–25,634,014, 174 basesExon 7: 25,635,936–25,636,148, 213 basesExon 6: 25,637,215–25,637,312, 98 basesExon 5: 25,638,165–25,638,310, 146 basesExon 4: 25,642,322–25,642,385, 64 basesExon 3: 25,643,694–25,643,784, 91 basesExon 2: 25,645,300–25,645,470, 171 basesExon 1: 25,664,229–25,664,907, 679 bases3630201015′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.8 kb of the gene's 66.9 kb; 4,881 of those bases code for the protein.

How a genome test reads TOP2B

2

positions in TOP2B where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 66.9 kb of TOP2B, introns included, not only the 5.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TOP2B gene: DNA topoisomerase II beta. Retrieved 17 October 2026, from https://dantelabs.com/genes/top2b

Vancouver

Dante Labs. TOP2B gene: DNA topoisomerase II beta [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/top2b

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test