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Gene

FAS

Fas cell surface death receptor

Summary

Cytogenetic location
10q23.31
Coordinates
Chromosome 10: 88,990,798–89,017,059 (GRCh38)
Exons
9 exons across 26.3 kb
Protein
335 amino acids
Also known as
CD95, APO-1
Previous symbols
FAS1, APT1, TNFRSF6
MANE Select transcript
ENST00000652046.1NM_000043.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Autoimmune Disease

    • A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to their own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis).

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong

  • Autoimmune Lymphoproliferative Syndrome (ALPS)

    • Autoimmune lymphoproliferative syndrome

      Chronic lymph node and spleen enlargement, autoimmune cytopenias and raised double-negative T cells caused by changes in FAS, FASLG, CASP10 and related apoptosis genes.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Diagnosis allows sirolimus or other immunosuppression for cytopenias, avoidance of unnecessary splenectomy, lymphoma vigilance and family testing.

Broader groupings

  • Other Inborn Errors of Immunity

    • Inborn error of immunity

      One of 114 genes linked to it

      Inherited disorders of the immune system caused by changes in single genes, affecting how the body fights infection or regulates inflammation.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong

How FAS is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 10, with a bracket where FAS sits. FAS and 17 genes near it on chromosome 10, from 88,503,929 to 89,503,928.Chromosome 1010q23.31p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.388.6 Mb88.8 Mb89 Mb89.2 Mb89.4 MbRNLS: 88,273,551–88,584,530, reverse strandRNLSLIPJ: 88,586,753–88,607,880, forward strandLIPJLIPF: 88,664,441–88,678,814, forward strandLIPFLIPK: 88,706,249–88,752,776, forward strandLIPKLIPN: 88,759,982–88,779,626, forward strandLIPNLIPM: 88,802,730–88,820,546, forward strandLIPMANKRD22: 88,819,896–88,851,940, reverse strandANKRD22STAMBPL1: 88,879,363–88,975,153, forward strandSTAMBPL1ACTA2: 88,934,815–88,991,339, reverse strandACTA2FAS: 88,990,798–89,017,059, forward strandFASCH25H: 89,205,629–89,207,317, reverse strandCH25HLIPA: 89,212,830–89,415,367, reverse strandLIPAIFIT2: 89,283,694–89,309,271, forward strandIFIT2IFIT3: 89,327,307–89,377,473, forward strandIFIT3IFIT1B: 89,378,050–89,385,205, forward strandIFIT1BIFIT1: 89,392,546–89,406,487, forward strandIFIT1IFIT5: 89,414,568–89,421,605, forward strandIFIT5SLC16A12: 89,430,174–89,556,701, reverse strandSLC16A12Diagram of FAS: 9 exons on the forward strand of chromosome 10Exon 1: 1 known disease-causing siteExon 2: 8 known disease-causing sitesExon 3: 4 known disease-causing sitesExon 4: 8 known disease-causing sitesExon 5: 2 known disease-causing sitesExon 6: 4 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 8: 1 known disease-causing siteExon 9: 25 known disease-causing sitesExon 1: 88,990,798–88,990,906, 109 basesExon 2: 89,003,029–89,003,194, 166 basesExon 3: 89,007,700–89,007,837, 138 basesExon 4: 89,008,889–89,008,997, 109 basesExon 5: 89,010,539–89,010,600, 62 basesExon 6: 89,010,753–89,010,815, 63 basesExon 7: 89,011,999–89,012,081, 83 basesExon 8: 89,013,343–89,013,367, 25 basesExon 9: 89,014,119–89,017,059, 2,941 bases1246895′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.7 kb of the gene's 26.3 kb; 1,008 of those bases code for the protein.

How a genome test reads FAS

76

positions in FAS where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 26.3 kb of FAS, introns included, not only the 3.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FAS gene: Fas cell surface death receptor. Retrieved 16 October 2026, from https://dantelabs.com/genes/fas

Vancouver

Dante Labs. FAS gene: Fas cell surface death receptor [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/fas

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