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Trait
Abnormal pyramidal sign
Functional neurological abnormalities related to dysfunction of the pyramidal tract.
Summary
- Also called
- Corticospinal signs, Pyramidal signs, Pyramidal tract signs
- Body system
- Abnormality of the nervous system
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Add .json to the page's address, or ask for application/json, to read it as JSON.
library(jsonlite)
url <- "https://dantelabs.com/traits/abnormal-pyramidal-sign.json"
page <- fromJSON(url)
page$trait$nameAbnormal pyramidal signHP:0007256
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Get my Genome Test213 genes linked to Abnormal pyramidal sign
Changes in these genes cause rare conditions in which Abnormal pyramidal sign is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ABCB1ATP binding cassette subfamily B member 1 | Always | In 1 condition |
| AIMP1aminoacyl tRNA synthetase complex interacting multifunctional protein 1 | Always | In 1 condition |
| ALG13ALG13 UDP-N-acetylglucosaminyltransferase subunit | Always | In 1 condition |
| ASPAaspartoacylase | Always | In 1 condition |
| BCAP31B cell receptor associated protein 31 | Always | In 2 conditions |
| CCT3chaperonin containing TCP1 subunit 3 | Always | In 1 condition |
| CHP1calcineurin like EF-hand protein 1 | Always | In 1 condition |
| FBXO7F-box protein 7 | Always | In 1 condition |
| HTRA1HtrA serine peptidase 1 | Always | In 2 conditions |
| HTThuntingtin | Always | In 1 condition |
| KARS1lysyl-tRNA synthetase 1 | Always | In 1 condition |
| MAGmyelin associated glycoprotein | Always | In 2 conditions |
| NDUFA13NADH:ubiquinone oxidoreductase subunit A13 | Always | In 1 condition |
| NKX6-2NK6 homeobox 2 | Always | In 2 conditions |
| NOTCH3notch receptor 3 | Always | In 1 condition |
| PLAAphospholipase A2 activating protein | Always | In 1 condition |
| POLR3BRNA polymerase III subunit B | Always | In 1 condition |
| RTTNrotatin | Always | In 2 conditions |
| SLC19A3solute carrier family 19 member 3 | Always | In 1 condition |
| SLC25A15solute carrier family 25 member 15 | Always | In 2 conditions |
| SNCAsynuclein alpha | Always | In 1 condition |
| SOD1superoxide dismutase 1 | Always | In 1 condition |
| SPG11SPG11 vesicle trafficking associated, spatacsin | Always | In 1 condition |
| ALS2alsin Rho guanine nucleotide exchange factor ALS2 | Very often (80–99%) | In 2 conditions |
| ATP13A2ATPase cation transporting 13A2 | Very often (80–99%) | In 3 conditions |
| ATXN3ataxin 3 | Very often (80–99%) | In 3 conditions |
| ERLIN2ER lipid raft associated 2 | Very often (80–99%) | In 1 condition |
| GBE11,4-alpha-glucan branching enzyme 1 | Very often (80–99%) | In 1 condition |
| GM2Aganglioside GM2 activator | Very often (80–99%) | In 2 conditions |
| HYCC1hyccin PI4KA lipid kinase complex subunit 1 | Very often (80–99%) | In 2 conditions |
| MAPTmicrotubule associated protein tau | Very often (80–99%) | In 3 conditions |
| NAGAalpha-N-acetylgalactosaminidase | Very often (80–99%) | In 1 condition |
| PANK2pantothenate kinase 2 | Very often (80–99%) | In 2 conditions |
| PEX7peroxisomal biogenesis factor 7 | Very often (80–99%) | In 1 condition |
| PHYHphytanoyl-CoA 2-hydroxylase | Very often (80–99%) | In 1 condition |
| PLP1proteolipid protein 1 | Very often (80–99%) | In 2 conditions |
| SOX10SRY-box transcription factor 10 | Very often (80–99%) | In 1 condition |
| SPG21SPG21 abhydrolase domain containing, maspardin | Very often (80–99%) | In 1 condition |
| SPTAN1spectrin alpha, non-erythrocytic 1 | Very often (80–99%) | In 1 condition |
| TBC1D24TBC1 domain family member 24 | Very often (80–99%) | In 1 condition |
Show 173 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| THG1LtRNA-histidine guanylyltransferase 1 like | Very often (80–99%) | In 1 condition |
| TTPAalpha tocopherol transfer protein | Very often (80–99%) | In 1 condition |
| UBTFupstream binding transcription factor | Very often (80–99%) | In 2 conditions |
| VPS13Dvacuolar protein sorting 13 homolog D | Very often (80–99%) | In 2 conditions |
| VPS41VPS41 subunit of HOPS complex | Very often (80–99%) | In 1 condition |
| ACADSacyl-CoA dehydrogenase short chain | Often (30–79%) | In 1 condition |
| ADD3adducin 3 | Often (30–79%) | In 1 condition |
| ADGRG1adhesion G protein-coupled receptor G1 | Often (30–79%) | In 1 condition |
| ALDH18A1aldehyde dehydrogenase 18 family member A1 | Often (30–79%) | In 1 condition |
| ARXaristaless related homeobox | Often (30–79%) | In 1 condition |
| BSCL2BSCL2 lipid droplet biogenesis associated, seipin | Often (30–79%) | In 2 conditions |
| C19orf12chromosome 19 open reading frame 12 | Often (30–79%) | In 1 condition |
| CLPBClpB family mitochondrial disaggregase | Often (30–79%) | In 1 condition |
| COA8cytochrome c oxidase assembly factor 8 | Often (30–79%) | In 1 condition |
| COQ2coenzyme Q2, polyprenyltransferase | Often (30–79%) | In 2 conditions |
| CYP27A1cytochrome P450 family 27 subfamily A member 1 | Often (30–79%) | In 2 conditions |
| DMXL2Dmx like 2 | Often (30–79%) | In 1 condition |
| DNAJC6DnaJ heat shock protein family (Hsp40) member C6 | Often (30–79%) | In 2 conditions |
| ETHE1ETHE1 persulfide dioxygenase | Often (30–79%) | In 1 condition |
| FKRPfukutin related protein | Often (30–79%) | In 1 condition |
| GBA2glucosylceramidase beta 2 | Often (30–79%) | In 2 conditions |
| GFAPglial fibrillary acidic protein | Often (30–79%) | In 1 condition |
| GMPPBGDP-mannose pyrophosphorylase B | Often (30–79%) | In 1 condition |
| HEXBhexosaminidase subunit beta | Often (30–79%) | In 1 condition |
| HSPD1heat shock protein family D (Hsp60) member 1 | Often (30–79%) | In 1 condition |
| IDUAalpha-L-iduronidase | Often (30–79%) | In 2 conditions |
| LIG3DNA ligase 3 | Often (30–79%) | In 1 condition |
| LMNB1lamin B1 | Often (30–79%) | In 1 condition |
| MDH2malate dehydrogenase 2 | Often (30–79%) | In 1 condition |
| MTFMTmitochondrial methionyl-tRNA formyltransferase | Often (30–79%) | In 1 condition |
| MTRFRmitochondrial translation release factor in rescue | Often (30–79%) | In 1 condition |
| NAA60N-alpha-acetyltransferase 60, NatF catalytic subunit | Often (30–79%) | In 3 conditions |
| PEX10peroxisomal biogenesis factor 10 | Often (30–79%) | In 1 condition |
| PLA2G6phospholipase A2 group VI | Often (30–79%) | In 2 conditions |
| PODXLpodocalyxin like | Often (30–79%) | In 1 condition |
| POMGNT1protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) | Often (30–79%) | In 1 condition |
| POMKprotein O-mannose kinase | Often (30–79%) | In 1 condition |
| POMT1protein O-mannosyltransferase 1 | Often (30–79%) | In 1 condition |
| POMT2protein O-mannosyltransferase 2 | Often (30–79%) | In 1 condition |
| PRKRAprotein activator of interferon induced protein kinase EIF2AK2 | Often (30–79%) | In 2 conditions |
| PRNPprion protein (Kanno blood group) | Often (30–79%) | In 2 conditions |
| SACSsacsin molecular chaperone | Often (30–79%) | In 1 condition |
| SETXsenataxin | Often (30–79%) | In 3 conditions |
| SLC16A2solute carrier family 16 member 2 | Often (30–79%) | In 1 condition |
| SLC2A1solute carrier family 2 member 1 | Often (30–79%) | In 4 conditions |
| SLC6A3solute carrier family 6 member 3 | Often (30–79%) | In 2 conditions |
| SNORD118small nucleolar RNA, C/D box 118 | Often (30–79%) | In 2 conditions |
| SPG7SPG7 matrix AAA peptidase subunit, paraplegin | Often (30–79%) | In 1 condition |
| SYNJ1synaptojanin 1 | Often (30–79%) | In 1 condition |
| TACO1translational activator of cytochrome c oxidase I | Often (30–79%) | In 1 condition |
| TAF2TATA-box binding protein associated factor 2 | Often (30–79%) | In 2 conditions |
| TBPTATA-box binding protein | Often (30–79%) | In 1 condition |
| TIMM8Atranslocase of inner mitochondrial membrane 8A | Often (30–79%) | In 1 condition |
| TTRtransthyretin | Often (30–79%) | In 1 condition |
| VAPBVAMP associated protein B and C | Often (30–79%) | In 1 condition |
| VPS13Cvacuolar protein sorting 13 homolog C | Often (30–79%) | In 1 condition |
| WARS2tryptophanyl tRNA synthetase 2, mitochondrial | Often (30–79%) | In 1 condition |
| AARS1alanyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| ADARadenosine deaminase RNA specific | Sometimes (5–29%) | In 1 condition |
| ATMATM serine/threonine kinase | Sometimes (5–29%) | In 1 condition |
| ATP1A2ATPase Na+/K+ transporting subunit alpha 2 | Sometimes (5–29%) | In 1 condition |
| ATP1A3ATPase Na+/K+ transporting subunit alpha 3 | Sometimes (5–29%) | In 1 condition |
| BMPR1Abone morphogenetic protein receptor type 1A | Sometimes (5–29%) | In 1 condition |
| BRCA2BRCA2 DNA repair associated | Sometimes (5–29%) | In 1 condition |
| C4Acomplement C4A (Chido/Rodgers blood group) | Sometimes (5–29%) | In 1 condition |
| CACNA1Acalcium voltage-gated channel subunit alpha1 A | Sometimes (5–29%) | In 1 condition |
| CARS1cysteinyl-tRNA synthetase 1 | Sometimes (5–29%) | In 2 conditions |
| CCR1C-C motif chemokine receptor 1 | Sometimes (5–29%) | In 1 condition |
| CD4CD4 molecule | Sometimes (5–29%) | In 1 condition |
| CHEK2checkpoint kinase 2 | Sometimes (5–29%) | In 1 condition |
| CMPK2cytidine/uridine monophosphate kinase 2 | Sometimes (5–29%) | In 1 condition |
| COQ8Acoenzyme Q8A | Sometimes (5–29%) | In 2 conditions |
| CTDP1CTD phosphatase 1 | Sometimes (5–29%) | In 1 condition |
| DBR1debranching RNA lariats 1 | Sometimes (5–29%) | In 1 condition |
| DPYSdihydropyrimidinase | Sometimes (5–29%) | In 1 condition |
| EPCAMepithelial cell adhesion molecule | Sometimes (5–29%) | In 1 condition |
| EPRS1glutamyl-prolyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| ERAP1endoplasmic reticulum aminopeptidase 1 | Sometimes (5–29%) | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Sometimes (5–29%) | In 1 condition |
| ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit | Sometimes (5–29%) | In 1 condition |
| FASFas cell surface death receptor | Sometimes (5–29%) | In 1 condition |
| FUCA1alpha-L-fucosidase 1 | Sometimes (5–29%) | In 1 condition |
| GTF2E2general transcription factor IIE subunit 2 | Sometimes (5–29%) | In 1 condition |
| GTF2H5general transcription factor IIH subunit 5 | Sometimes (5–29%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Sometimes (5–29%) | In 1 condition |
| IFIH1interferon induced with helicase C domain 1 | Sometimes (5–29%) | In 1 condition |
| IFNGR1interferon gamma receptor 1 | Sometimes (5–29%) | In 1 condition |
| IL10interleukin 10 | Sometimes (5–29%) | In 1 condition |
| IL12Ainterleukin 12A | Sometimes (5–29%) | In 1 condition |
| IL12A-AS1IL12A antisense RNA 1 | Sometimes (5–29%) | In 1 condition |
| IL23Rinterleukin 23 receptor | Sometimes (5–29%) | In 1 condition |
| IRF4interferon regulatory factor 4 | Sometimes (5–29%) | In 1 condition |
| ITPR1inositol 1,4,5-trisphosphate receptor type 1 | Sometimes (5–29%) | In 1 condition |
| JAM2junctional adhesion molecule 2 | Sometimes (5–29%) | In 2 conditions |
| KIF1Ckinesin family member 1C | Sometimes (5–29%) | In 1 condition |
| KLRC4killer cell lectin like receptor C4 | Sometimes (5–29%) | In 1 condition |
| KMT2Blysine methyltransferase 2B | Sometimes (5–29%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Sometimes (5–29%) | In 1 condition |
| LSM11LSM11, U7 small nuclear RNA associated | Sometimes (5–29%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Sometimes (5–29%) | In 1 condition |
| MLH1mutL homolog 1 | Sometimes (5–29%) | In 1 condition |
| MORC2MORC family CW-type zinc finger 2 | Sometimes (5–29%) | In 1 condition |
| MPLKIPM-phase specific PLK1 interacting protein | Sometimes (5–29%) | In 1 condition |
| MSH2mutS homolog 2 | Sometimes (5–29%) | In 1 condition |
| MSH6mutS homolog 6 | Sometimes (5–29%) | In 1 condition |
| MT-ATP6mitochondrially encoded ATP synthase membrane subunit 6 | Sometimes (5–29%) | In 1 condition |
| MT-TL2mitochondrially encoded tRNA-Leu (CUN) 2 | Sometimes (5–29%) | In 1 condition |
| MUTYHmutY DNA glycosylase | Sometimes (5–29%) | In 1 condition |
| MYORGmyogenesis regulating glycosidase | Sometimes (5–29%) | In 3 conditions |
| NDUFS2NADH:ubiquinone oxidoreductase core subunit S2 | Sometimes (5–29%) | In 1 condition |
| NPATnuclear protein, coactivator of histone transcription | Sometimes (5–29%) | In 1 condition |
| PDGFBplatelet derived growth factor subunit B | Sometimes (5–29%) | In 2 conditions |
| PDGFRBplatelet derived growth factor receptor beta | Sometimes (5–29%) | In 2 conditions |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Sometimes (5–29%) | In 1 condition |
| PIK3R5phosphoinositide-3-kinase regulatory subunit 5 | Sometimes (5–29%) | In 1 condition |
| PMS1PMS1 homolog 1, mismatch repair system component | Sometimes (5–29%) | In 1 condition |
| PMS2PMS1 homolog 2, mismatch repair system component | Sometimes (5–29%) | In 1 condition |
| PNKPpolynucleotide kinase 3'-phosphatase | Sometimes (5–29%) | In 1 condition |
| POLD1DNA polymerase delta 1, catalytic subunit | Sometimes (5–29%) | In 1 condition |
| POLEDNA polymerase epsilon, catalytic subunit | Sometimes (5–29%) | In 1 condition |
| PPP2R2Bprotein phosphatase 2 regulatory subunit Bbeta | Sometimes (5–29%) | In 1 condition |
| RHOBTB2Rho related BTB domain containing 2 | Sometimes (5–29%) | In 1 condition |
| RNASEH1ribonuclease H1 | Sometimes (5–29%) | In 2 conditions |
| RNASEH2Aribonuclease H2 subunit A | Sometimes (5–29%) | In 1 condition |
| RNASEH2Bribonuclease H2 subunit B | Sometimes (5–29%) | In 1 condition |
| RNASEH2Cribonuclease H2 subunit C | Sometimes (5–29%) | In 1 condition |
| RNF113Aring finger protein 113A | Sometimes (5–29%) | In 1 condition |
| RNU7-1RNA, U7 small nuclear 1 | Sometimes (5–29%) | In 1 condition |
| RORARAR related orphan receptor A | Sometimes (5–29%) | In 1 condition |
| RPS20ribosomal protein S20 | Sometimes (5–29%) | In 1 condition |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Sometimes (5–29%) | In 1 condition |
| RRP12ribosomal RNA processing 12 homolog | Sometimes (5–29%) | In 1 condition |
| SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Sometimes (5–29%) | In 1 condition |
| SCN2Asodium voltage-gated channel alpha subunit 2 | Sometimes (5–29%) | In 1 condition |
| SEMA4Asemaphorin 4A | Sometimes (5–29%) | In 1 condition |
| SLC1A3solute carrier family 1 member 3 | Sometimes (5–29%) | In 1 condition |
| SLC20A2solute carrier family 20 member 2 | Sometimes (5–29%) | In 2 conditions |
| SQSTM1sequestosome 1 | Sometimes (5–29%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Sometimes (5–29%) | In 1 condition |
| TARS1threonyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| TGFBR2transforming growth factor beta receptor 2 | Sometimes (5–29%) | In 1 condition |
| THAP11THAP domain containing 11 | Sometimes (5–29%) | In 1 condition |
| TLR4toll like receptor 4 | Sometimes (5–29%) | In 1 condition |
| TMEM106Btransmembrane protein 106B | Sometimes (5–29%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Sometimes (5–29%) | In 1 condition |
| UBAC2UBA domain containing 2 | Sometimes (5–29%) | In 1 condition |
| XPR1xenotropic and polytropic retrovirus receptor 1 | Sometimes (5–29%) | In 2 conditions |
| AP2M1adaptor related protein complex 2 subunit mu 1 | Rarely (1–4%) | In 1 condition |
| CAMTA1calmodulin binding transcription activator 1 | Rarely (1–4%) | In 1 condition |
| CHD2chromodomain helicase DNA binding protein 2 | Rarely (1–4%) | In 1 condition |
| NEXMIFneurite extension and migration factor | Rarely (1–4%) | In 1 condition |
| POU4F1POU class 4 homeobox 1 | Rarely (1–4%) | In 1 condition |
| SCN1Asodium voltage-gated channel alpha subunit 1 | Rarely (1–4%) | In 2 conditions |
| SLC6A1solute carrier family 6 member 1 | Rarely (1–4%) | In 1 condition |
| SYNGAP1synaptic Ras GTPase activating protein 1 | Rarely (1–4%) | In 1 condition |
| TTBK2tau tubulin kinase 2 | Rarely (1–4%) | In 1 condition |
| ATXN10ataxin 10 | Not recorded | In 1 condition |
| ATXN8ataxin 8 | Not recorded | In 1 condition |
| ATXN8OSATXN8 opposite strand lncRNA | Not recorded | In 1 condition |
| CACNA1Gcalcium voltage-gated channel subunit alpha1 G | Not recorded | In 1 condition |
| CTC1CST telomere replication complex component 1 | Not recorded | In 1 condition |
| ELOVL4ELOVL fatty acid elongase 4 | Not recorded | In 1 condition |
| GANgigaxonin | Not recorded | In 1 condition |
| GLRX5glutaredoxin 5 | Not recorded | In 1 condition |
| GRM1glutamate metabotropic receptor 1 | Not recorded | In 1 condition |
| KCNC3potassium voltage-gated channel subfamily C member 3 | Not recorded | In 1 condition |
| L2HGDHL-2-hydroxyglutarate dehydrogenase | Not recorded | In 1 condition |
| MAN2B1mannosidase alpha class 2B member 1 | Not recorded | In 1 condition |
| NALCNsodium leak channel, non-selective | Not recorded | In 1 condition |
| NDUFS7NADH:ubiquinone oxidoreductase core subunit S7 | Not recorded | In 1 condition |
| SCN1Bsodium voltage-gated channel beta subunit 1 | Not recorded | In 1 condition |
| SLC12A5solute carrier family 12 member 5 | Not recorded | In 1 condition |
| VWA3Bvon Willebrand factor A domain containing 3B | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.17-8666dff2.
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