Trait
Fluid around lungs
Clinical name: Pleural effusion
The presence of an excessive amount of fluid in the pleural cavity.
Summary
Reference genomeGRCh38hg38
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Changes in these genes cause rare conditions in which Fluid around lungs is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ACTN4actinin alpha 4 | Always | In 1 condition |
| BLTP1bridge-like lipid transfer protein family member 1 | Always | In 1 condition |
| CYBBcytochrome b-245 beta chain | Always | In 1 condition |
| CYBC1cytochrome b-245 chaperone 1 | Always | In 1 condition |
| GAAalpha glucosidase | Always | In 1 condition |
| ITKIL2 inducible T cell kinase | Always | In 1 condition |
| PLVAPplasmalemma vesicle associated protein | Always | In 1 condition |
| VPS51VPS51 subunit of GARP complex | Always | In 1 condition |
| BAP1BRCA1 associated deubiquitinase 1 | Very often (80–99%) | In 1 condition |
| BTNL2butyrophilin like 2 | Often (30–79%) | In 2 conditions |
| CAV1caveolin 1 | Often (30–79%) | In 1 condition |
| DEF6DEF6 guanine nucleotide exchange factor | Often (30–79%) | In 1 condition |
| DSTdystonin | Often (30–79%) | In 1 condition |
| EPHB4EPH receptor B4 | Often (30–79%) | In 2 conditions |
| FSHRfollicle stimulating hormone receptor | Often (30–79%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Often (30–79%) | In 4 conditions |
| IRAK1interleukin 1 receptor associated kinase 1 | Often (30–79%) | In 1 condition |
| MTO1mitochondrial tRNA translation optimization 1 | Often (30–79%) | In 1 condition |
| NEXNnexilin F-actin binding protein | Often (30–79%) | In 1 condition |
| PLD4phospholipase D family member 4 | Often (30–79%) | In 1 condition |
| PRKAG2protein kinase AMP-activated non-catalytic subunit gamma 2 | Often (30–79%) | In 1 condition |
| SAT1spermidine/spermine N1-acetyltransferase 1 | Often (30–79%) | In 1 condition |
| SCARB2scavenger receptor class B member 2 | Often (30–79%) | In 1 condition |
| SPP1secreted phosphoprotein 1 | Often (30–79%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Often (30–79%) | In 2 conditions |
| TNFtumor necrosis factor | Often (30–79%) | In 1 condition |
| AGR2anterior gradient 2, protein disulphide isomerase family member | Sometimes (5–29%) | In 1 condition |
| BCL2BCL2 apoptosis regulator | Sometimes (5–29%) | In 1 condition |
| BCL6BCL6 transcription repressor | Sometimes (5–29%) | In 1 condition |
| C4Acomplement C4A (Chido/Rodgers blood group) | Sometimes (5–29%) | In 1 condition |
| CCR1C-C motif chemokine receptor 1 | Sometimes (5–29%) | In 1 condition |
| CD46CD46 molecule | Sometimes (5–29%) | In 1 condition |
| CFHcomplement factor H | Sometimes (5–29%) | In 1 condition |
| CFIcomplement factor I | Sometimes (5–29%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Sometimes (5–29%) | In 1 condition |
| DNASE1L3deoxyribonuclease 1L3 | Sometimes (5–29%) | In 1 condition |
| EIF2AK4eukaryotic translation initiation factor 2 alpha kinase 4 | Sometimes (5–29%) | In 1 condition |
| ERAP1endoplasmic reticulum aminopeptidase 1 | Sometimes (5–29%) | In 1 condition |
| FASFas cell surface death receptor | Sometimes (5–29%) | In 1 condition |
| GPR35G protein-coupled receptor 35 | Sometimes (5–29%) | In 1 condition |
Show 46 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| HELLPARHELLP associated long non-coding RNA | Sometimes (5–29%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Sometimes (5–29%) | In 1 condition |
| HLA-DPA1major histocompatibility complex, class II, DP alpha 1 | Sometimes (5–29%) | In 1 condition |
| HLA-DPB1major histocompatibility complex, class II, DP beta 1 | Sometimes (5–29%) | In 1 condition |
| IFIH1interferon induced with helicase C domain 1 | Sometimes (5–29%) | In 1 condition |
| IFNGR1interferon gamma receptor 1 | Sometimes (5–29%) | In 1 condition |
| IGHimmunoglobulin heavy locus | Sometimes (5–29%) | In 1 condition |
| IL10interleukin 10 | Sometimes (5–29%) | In 1 condition |
| IL12Ainterleukin 12A | Sometimes (5–29%) | In 1 condition |
| IL12A-AS1IL12A antisense RNA 1 | Sometimes (5–29%) | In 1 condition |
| IL23Rinterleukin 23 receptor | Sometimes (5–29%) | In 1 condition |
| IL6interleukin 6 | Sometimes (5–29%) | In 1 condition |
| KIF11kinesin family member 11 | Sometimes (5–29%) | In 1 condition |
| KLRC4killer cell lectin like receptor C4 | Sometimes (5–29%) | In 1 condition |
| LACC1laccase domain multifunctional purine nucleosidase 1 | Sometimes (5–29%) | In 1 condition |
| LYSTlysosomal trafficking regulator | Sometimes (5–29%) | In 1 condition |
| LZTR1leucine zipper like post translational regulator 1 | Sometimes (5–29%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Sometimes (5–29%) | In 2 conditions |
| MIFmacrophage migration inhibitory factor | Sometimes (5–29%) | In 1 condition |
| MST1macrophage stimulating 1 | Sometimes (5–29%) | In 1 condition |
| MYD88MYD88 innate immune signal transduction adaptor | Sometimes (5–29%) | In 1 condition |
| NR1H4nuclear receptor subfamily 1 group H member 4 | Sometimes (5–29%) | In 1 condition |
| PIEZO1piezo type mechanosensitive ion channel component 1 (Er blood group) | Sometimes (5–29%) | In 1 condition |
| PRTN3proteinase 3 | Sometimes (5–29%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Sometimes (5–29%) | In 1 condition |
| RIT1Ras like without CAAX 1 | Sometimes (5–29%) | In 1 condition |
| SCN4Asodium voltage-gated channel alpha subunit 4 | Sometimes (5–29%) | In 1 condition |
| SEMA4Dsemaphorin 4D | Sometimes (5–29%) | In 1 condition |
| SOX18SRY-box transcription factor 18 | Sometimes (5–29%) | In 1 condition |
| TCF4transcription factor 4 | Sometimes (5–29%) | In 1 condition |
| TLR4toll like receptor 4 | Sometimes (5–29%) | In 1 condition |
| UBAC2UBA domain containing 2 | Sometimes (5–29%) | In 1 condition |
| USP18ubiquitin specific peptidase 18 | Sometimes (5–29%) | In 1 condition |
| ZNFX1zinc finger NFX1-type containing 1 | Sometimes (5–29%) | In 1 condition |
| CCND1cyclin D1 | Rarely (1–4%) | In 1 condition |
| FOXF1forkhead box F1 | Rarely (1–4%) | In 1 condition |
| BMP2bone morphogenetic protein 2 | Not recorded | In 1 condition |
| CALCRLcalcitonin receptor like receptor | Not recorded | In 1 condition |
| CCBE1collagen and calcium binding EGF domains 1 | Not recorded | In 1 condition |
| CFTRCF transmembrane conductance regulator | Not recorded | In 1 condition |
| CTRCchymotrypsin C | Not recorded | In 1 condition |
| HFEhomeostatic iron regulator | Not recorded | In 1 condition |
| PRSS1serine protease 1 | Not recorded | In 1 condition |
| PRSS2serine protease 2 | Not recorded | In 1 condition |
| SPINK1serine peptidase inhibitor Kazal type 1 | Not recorded | In 1 condition |
| TAPT1transmembrane anterior posterior transformation 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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