Trait

High eye pressure

Clinical name: Ocular hypertension

Intraocular pressure that is 2 standard deviations above the population mean.

HPO HP:0007906

Also called: Elevated intraocular pressure, Elevated IOP, Increased intraocular pressure, Increased IOP, Raised intraocular pressure, Raised IOP
Body system: Abnormality of the eye

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35 genes linked to High eye pressure

Changes in these genes cause rare conditions in which High eye pressure is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
EFEMP1EGF-like fibulin extracellular matrix protein 1	Always	In 2 conditions
NOS3nitric oxide synthase 3	Always	In 1 condition
RDH8retinol dehydrogenase 8	Always	In 1 condition
HLA-Amajor histocompatibility complex, class I, A	Very often (80–99%)	In 1 condition
ADAMTS17ADAM metallopeptidase with thrombospondin type 1 motif 17	Often (30–79%)	In 1 condition
ASPHaspartate beta-hydroxylase	Often (30–79%)	In 1 condition
CHST14carbohydrate sulfotransferase 14	Often (30–79%)	In 1 condition
COL18A1collagen type XVIII alpha 1 chain	Often (30–79%)	In 1 condition
CYP1B1cytochrome P450 family 1 subfamily B member 1	Often (30–79%)	In 3 conditions
DSEdermatan sulfate epimerase	Often (30–79%)	In 1 condition
FASFas cell surface death receptor	Often (30–79%)	In 1 condition
GLIS3GLIS family zinc finger 3	Often (30–79%)	In 1 condition
HLA-DRB1major histocompatibility complex, class II, DR beta 1	Often (30–79%)	In 1 condition
LTBP2latent transforming growth factor beta binding protein 2	Often (30–79%)	In 2 conditions
MYOCmyocilin	Often (30–79%)	In 2 conditions
PRSS56serine protease 56	Often (30–79%)	In 1 condition
PTPN22protein tyrosine phosphatase non-receptor type 22	Often (30–79%)	In 1 condition
PXDNperoxidasin	Often (30–79%)	In 1 condition
TEKTEK receptor tyrosine kinase	Often (30–79%)	In 2 conditions
VSX1visual system homeobox 1	Often (30–79%)	In 2 conditions
HGDhomogentisate 1,2-dioxygenase	Sometimes (5–29%)	In 1 condition
LMX1BLIM homeobox transcription factor 1 beta	Sometimes (5–29%)	In 1 condition
NFIAnuclear factor I A	Sometimes (5–29%)	In 1 condition
SLC39A14solute carrier family 39 member 14	Sometimes (5–29%)	In 1 condition
C1QTNF5C1q and TNF related 5	Rarely (1–4%)	In 1 condition
COL2A1collagen type II alpha 1 chain	Rarely (1–4%)	In 1 condition
COL8A2collagen type VIII alpha 2 chain	Rarely (1–4%)	In 1 condition
FN1fibronectin 1	Rarely (1–4%)	In 1 condition
GRHL2grainyhead like transcription factor 2	Rarely (1–4%)	In 1 condition
OVOL2ovo like zinc finger 2	Rarely (1–4%)	In 1 condition
ZEB1zinc finger E-box binding homeobox 1	Rarely (1–4%)	In 1 condition
ASB10ankyrin repeat and SOCS box containing 10	Not recorded	In 1 condition
FOXE3forkhead box E3	Not recorded	In 1 condition
HMX1H6 family homeobox 1	Not recorded	In 1 condition
PITX3paired like homeodomain 3	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Asymmetry of intraocular pressure

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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