Trait
Muscle inflammation
Clinical name: Myositis
A general term for inflammation of the muscles without respect to the underlying cause.
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test46 genes linked to Muscle inflammation
Changes in these genes cause rare conditions in which Muscle inflammation is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| PSMB9proteasome 20S subunit beta 9 | Always | In 1 condition |
| PSMG2proteasome assembly chaperone 2 | Always | In 1 condition |
| LAMA2laminin subunit alpha 2 | Very often (80–99%) | In 1 condition |
| ARPC5actin related protein 2/3 complex subunit 5 | Often (30–79%) | In 1 condition |
| LPIN1lipin 1 | Often (30–79%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Often (30–79%) | In 2 conditions |
| MT-CO1mitochondrially encoded cytochrome c oxidase I | Often (30–79%) | In 1 condition |
| MT-CO3mitochondrially encoded cytochrome c oxidase III | Often (30–79%) | In 1 condition |
| OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | Often (30–79%) | In 1 condition |
| PTPN6protein tyrosine phosphatase non-receptor type 6 | Often (30–79%) | In 1 condition |
| STING1stimulator of interferon response cGAMP interactor 1 | Often (30–79%) | In 1 condition |
| C4Acomplement C4A (Chido/Rodgers blood group) | Sometimes (5–29%) | In 1 condition |
| CCR1C-C motif chemokine receptor 1 | Sometimes (5–29%) | In 1 condition |
| CD4CD4 molecule | Sometimes (5–29%) | In 1 condition |
| DTNAdystrobrevin alpha | Sometimes (5–29%) | In 1 condition |
| ERAP1endoplasmic reticulum aminopeptidase 1 | Sometimes (5–29%) | In 1 condition |
| FASFas cell surface death receptor | Sometimes (5–29%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Sometimes (5–29%) | In 1 condition |
| IFNGR1interferon gamma receptor 1 | Sometimes (5–29%) | In 1 condition |
| IL10interleukin 10 | Sometimes (5–29%) | In 1 condition |
| IL12Ainterleukin 12A | Sometimes (5–29%) | In 1 condition |
| IL12A-AS1IL12A antisense RNA 1 | Sometimes (5–29%) | In 1 condition |
| IL23Rinterleukin 23 receptor | Sometimes (5–29%) | In 1 condition |
| IRF4interferon regulatory factor 4 | Sometimes (5–29%) | In 1 condition |
| KLRC4killer cell lectin like receptor C4 | Sometimes (5–29%) | In 1 condition |
| PSTPIP1proline-serine-threonine phosphatase interacting protein 1 | Sometimes (5–29%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Sometimes (5–29%) | In 2 conditions |
| TLR4toll like receptor 4 | Sometimes (5–29%) | In 1 condition |
| TNFRSF1ATNF receptor superfamily member 1A | Sometimes (5–29%) | In 2 conditions |
| UBAC2UBA domain containing 2 | Sometimes (5–29%) | In 1 condition |
| ADARadenosine deaminase RNA specific | Rarely (1–4%) | In 1 condition |
| FOXP3forkhead box P3 | Rarely (1–4%) | In 1 condition |
| IFIH1interferon induced with helicase C domain 1 | Rarely (1–4%) | In 1 condition |
| IRAK1interleukin 1 receptor associated kinase 1 | Rarely (1–4%) | In 1 condition |
| LSM11LSM11, U7 small nuclear RNA associated | Rarely (1–4%) | In 1 condition |
| RNASEH2Aribonuclease H2 subunit A | Rarely (1–4%) | In 1 condition |
| RNASEH2Bribonuclease H2 subunit B | Rarely (1–4%) | In 1 condition |
| RNASEH2Cribonuclease H2 subunit C | Rarely (1–4%) | In 1 condition |
| RNU7-1RNA, U7 small nuclear 1 | Rarely (1–4%) | In 1 condition |
| SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Rarely (1–4%) | In 1 condition |
Show 6 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SAT1spermidine/spermine N1-acetyltransferase 1 | Rarely (1–4%) | In 1 condition |
| SPP1secreted phosphoprotein 1 | Rarely (1–4%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Rarely (1–4%) | In 1 condition |
| CAPN3calpain 3 | Not recorded | In 1 condition |
| HNRNPA2B1heterogeneous nuclear ribonucleoprotein A2/B1 | Not recorded | In 1 condition |
| PSMB4proteasome 20S subunit beta 4 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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