Trait
Hives
Clinical name: Urticaria
Raised, well-circumscribed areas of erythema and edema involving the dermis and epidermis. Urticaria is intensely pruritic, and blanches completely with pressure.
Summary
Reference genomeGRCh38hg38
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Get my Genome Test41 genes linked to Hives
Changes in these genes cause rare conditions in which Hives is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ADGRE2adhesion G protein-coupled receptor E2 | Always | In 1 condition |
| LYNLYN proto-oncogene, Src family tyrosine kinase | Always | In 1 condition |
| NLRC4NLR family CARD domain containing 4 | Always | In 2 conditions |
| NLRP3NLR family pyrin domain containing 3 | Always | In 6 conditions |
| PLD4phospholipase D family member 4 | Always | In 1 condition |
| ANTXR2ANTXR cell adhesion molecule 2 | Very often (80–99%) | In 1 condition |
| ELOVL4ELOVL fatty acid elongase 4 | Very often (80–99%) | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Very often (80–99%) | In 1 condition |
| ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit | Very often (80–99%) | In 1 condition |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Very often (80–99%) | In 1 condition |
| ERCC5ERCC excision repair 5, endonuclease | Very often (80–99%) | In 1 condition |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Very often (80–99%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Very often (80–99%) | In 1 condition |
| KITKIT proto-oncogene, receptor tyrosine kinase | Very often (80–99%) | In 4 conditions |
| NLRP12NLR family pyrin domain containing 12 | Very often (80–99%) | In 1 condition |
| SERPING1serpin family G member 1 | Very often (80–99%) | In 1 condition |
| CBLBCbl proto-oncogene B | Often (30–79%) | In 1 condition |
| MVKmevalonate kinase | Often (30–79%) | In 1 condition |
| RAC2Rac family small GTPase 2 | Often (30–79%) | In 1 condition |
| ALPK1alpha kinase 1 | Sometimes (5–29%) | In 1 condition |
| ASXL1ASXL transcriptional regulator 1 | Sometimes (5–29%) | In 2 conditions |
| CASP10caspase 10 | Sometimes (5–29%) | In 2 conditions |
| CBLCbl proto-oncogene | Sometimes (5–29%) | In 1 condition |
| CBScystathionine beta-synthase | Sometimes (5–29%) | In 1 condition |
| FASFas cell surface death receptor | Sometimes (5–29%) | In 2 conditions |
| FASLGFas ligand | Sometimes (5–29%) | In 2 conditions |
| FOXP3forkhead box P3 | Sometimes (5–29%) | In 1 condition |
| GNB2G protein subunit beta 2 | Sometimes (5–29%) | In 1 condition |
| IFIH1interferon induced with helicase C domain 1 | Sometimes (5–29%) | In 1 condition |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Sometimes (5–29%) | In 1 condition |
| MYD88MYD88 innate immune signal transduction adaptor | Sometimes (5–29%) | In 1 condition |
| RUNX1RUNX family transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| SPINK5serine peptidase inhibitor Kazal type 5 | Sometimes (5–29%) | In 2 conditions |
| SRSF2serine and arginine rich splicing factor 2 | Sometimes (5–29%) | In 2 conditions |
| TET2tet methylcytosine dioxygenase 2 | Sometimes (5–29%) | In 2 conditions |
| WASWASP actin nucleation promoting factor | Sometimes (5–29%) | In 1 condition |
| CPN1carboxypeptidase N subunit 1 | Not recorded | In 1 condition |
| SDHBsuccinate dehydrogenase complex iron sulfur subunit B | Not recorded | In 1 condition |
| SDHCsuccinate dehydrogenase complex subunit C | Not recorded | In 1 condition |
| SF3B4splicing factor 3b subunit 4 | Not recorded | In 1 condition |
Show 1 more gene
| Gene | How often it is seen | Conditions |
|---|---|---|
| XPNPEP2X-prolyl aminopeptidase 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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