Trait
Autoimmunity
The occurrence of an immune reaction against the organism's own cells or tissues.
Summary
- Also called
- Autoimmune disease, Autoimmune disorder, Autoimmune condition
- Body system
- Abnormality of the immune system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test128 genes linked to Autoimmunity
Changes in these genes cause rare conditions in which Autoimmunity is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| LCKLCK proto-oncogene, Src family tyrosine kinase | Always | In 1 condition |
| TBK1TANK binding kinase 1 | Always | In 1 condition |
| TRACT cell receptor alpha constant | Always | In 1 condition |
| AIREautoimmune regulator | Very often (80–99%) | In 1 condition |
| CASP10caspase 10 | Very often (80–99%) | In 1 condition |
| CAV1caveolin 1 | Very often (80–99%) | In 2 conditions |
| CCN2cellular communication network factor 2 | Very often (80–99%) | In 2 conditions |
| CCR6C-C motif chemokine receptor 6 | Very often (80–99%) | In 2 conditions |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Very often (80–99%) | In 1 condition |
| FASFas cell surface death receptor | Very often (80–99%) | In 1 condition |
| FASLGFas ligand | Very often (80–99%) | In 1 condition |
| FOXP3forkhead box P3 | Very often (80–99%) | In 1 condition |
| GPR35G protein-coupled receptor 35 | Very often (80–99%) | In 1 condition |
| HLA-DPA1major histocompatibility complex, class II, DP alpha 1 | Very often (80–99%) | In 1 condition |
| HLA-DPB1major histocompatibility complex, class II, DP beta 1 | Very often (80–99%) | In 1 condition |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Very often (80–99%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Very often (80–99%) | In 4 conditions |
| IL6interleukin 6 | Very often (80–99%) | In 2 conditions |
| IRF5interferon regulatory factor 5 | Very often (80–99%) | In 3 conditions |
| KIAA0319LKIAA0319 like | Very often (80–99%) | In 1 condition |
| LACC1laccase domain multifunctional purine nucleosidase 1 | Very often (80–99%) | In 1 condition |
| MIFmacrophage migration inhibitory factor | Very often (80–99%) | In 1 condition |
| MST1macrophage stimulating 1 | Very often (80–99%) | In 1 condition |
| PGM3phosphoglucomutase 3 | Very often (80–99%) | In 1 condition |
| PRTN3proteinase 3 | Very often (80–99%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Very often (80–99%) | In 2 conditions |
| SEMA4Dsemaphorin 4D | Very often (80–99%) | In 1 condition |
| TCF4transcription factor 4 | Very often (80–99%) | In 1 condition |
| ACP5acid phosphatase 5, tartrate resistant | Often (30–79%) | In 2 conditions |
| ADAadenosine deaminase | Often (30–79%) | In 2 conditions |
| ADARadenosine deaminase RNA specific | Often (30–79%) | In 1 condition |
| ANKRD55ankyrin repeat domain 55 | Often (30–79%) | In 1 condition |
| CD247CD247 molecule | Often (30–79%) | In 1 condition |
| DNASE1L3deoxyribonuclease 1L3 | Often (30–79%) | In 1 condition |
| FOXN1forkhead box N1 | Often (30–79%) | In 1 condition |
| IFIH1interferon induced with helicase C domain 1 | Often (30–79%) | In 1 condition |
| IGHG2immunoglobulin heavy constant gamma 2 (G2m marker) | Often (30–79%) | In 1 condition |
| IGKCimmunoglobulin kappa constant | Often (30–79%) | In 1 condition |
| IL12Ainterleukin 12A | Often (30–79%) | In 1 condition |
| IL12RB1interleukin 12 receptor subunit beta 1 | Often (30–79%) | In 1 condition |
Show 88 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| IL2RAinterleukin 2 receptor subunit alpha | Often (30–79%) | In 1 condition |
| IL2RBinterleukin 2 receptor subunit beta | Often (30–79%) | In 2 conditions |
| ITCHitchy E3 ubiquitin protein ligase | Often (30–79%) | In 2 conditions |
| LMNB2lamin B2 | Often (30–79%) | In 1 condition |
| LSM11LSM11, U7 small nuclear RNA associated | Often (30–79%) | In 1 condition |
| MMEL1membrane metalloendopeptidase like 1 | Often (30–79%) | In 1 condition |
| PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | Often (30–79%) | In 1 condition |
| PNPpurine nucleoside phosphorylase | Often (30–79%) | In 1 condition |
| POU2AF1POU class 2 homeobox associating factor 1 | Often (30–79%) | In 1 condition |
| PTPN2protein tyrosine phosphatase non-receptor type 2 | Often (30–79%) | In 1 condition |
| RNASEH2Aribonuclease H2 subunit A | Often (30–79%) | In 1 condition |
| RNASEH2Bribonuclease H2 subunit B | Often (30–79%) | In 1 condition |
| RNASEH2Cribonuclease H2 subunit C | Often (30–79%) | In 1 condition |
| RNU7-1RNA, U7 small nuclear 1 | Often (30–79%) | In 1 condition |
| SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Often (30–79%) | In 1 condition |
| SPIBSpi-B transcription factor | Often (30–79%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Often (30–79%) | In 1 condition |
| TNFSF15TNF superfamily member 15 | Often (30–79%) | In 1 condition |
| TNPO3transportin 3 | Often (30–79%) | In 1 condition |
| TPP2tripeptidyl peptidase 2 | Often (30–79%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Often (30–79%) | In 1 condition |
| WASWASP actin nucleation promoting factor | Often (30–79%) | In 1 condition |
| ARVCFARVCF delta catenin family member | Sometimes (5–29%) | In 1 condition |
| BTKBruton tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| CHD7chromodomain helicase DNA binding protein 7 | Sometimes (5–29%) | In 1 condition |
| CIITAclass II major histocompatibility complex transactivator | Sometimes (5–29%) | In 1 condition |
| COMTcatechol-O-methyltransferase | Sometimes (5–29%) | In 1 condition |
| DCLRE1CDNA cross-link repair 1C | Sometimes (5–29%) | In 2 conditions |
| DOCK8dedicator of cytokinesis 8 | Sometimes (5–29%) | In 1 condition |
| GP1BBglycoprotein Ib platelet subunit beta | Sometimes (5–29%) | In 1 condition |
| HIRAhistone cell cycle regulator | Sometimes (5–29%) | In 1 condition |
| HRHR lysine demethylase and nuclear receptor corepressor | Sometimes (5–29%) | In 1 condition |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Sometimes (5–29%) | In 1 condition |
| IL2RGinterleukin 2 receptor subunit gamma | Sometimes (5–29%) | In 1 condition |
| IL7Rinterleukin 7 receptor | Sometimes (5–29%) | In 1 condition |
| JMJD1Cjumonji domain containing 1C | Sometimes (5–29%) | In 1 condition |
| NFKBIANFKB inhibitor alpha | Sometimes (5–29%) | In 1 condition |
| NHEJ1non-homologous end joining factor 1 | Sometimes (5–29%) | In 1 condition |
| NUDCD3NudC domain containing 3 | Sometimes (5–29%) | In 1 condition |
| PIK3R1phosphoinositide-3-kinase regulatory subunit 1 | Sometimes (5–29%) | In 2 conditions |
| PSMB10proteasome 20S subunit beta 10 | Sometimes (5–29%) | In 1 condition |
| RAG1recombination activating 1 | Sometimes (5–29%) | In 3 conditions |
| RAG2recombination activating 2 | Sometimes (5–29%) | In 2 conditions |
| RFX5regulatory factor X5 | Sometimes (5–29%) | In 1 condition |
| RFXANKregulatory factor X associated ankyrin containing protein | Sometimes (5–29%) | In 1 condition |
| RFXAPregulatory factor X associated protein | Sometimes (5–29%) | In 1 condition |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Sometimes (5–29%) | In 1 condition |
| RREB1ras responsive element binding protein 1 | Sometimes (5–29%) | In 1 condition |
| SEC24CSEC24 homolog C, COPII component | Sometimes (5–29%) | In 1 condition |
| TBX1T-box transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| TTC7Atetratricopeptide repeat domain 7A | Sometimes (5–29%) | In 2 conditions |
| UFD1ubiquitin recognition factor in ER associated degradation 1 | Sometimes (5–29%) | In 1 condition |
| CORINcorin, serine peptidase | Rarely (1–4%) | In 1 condition |
| FLT1fms related receptor tyrosine kinase 1 | Rarely (1–4%) | In 1 condition |
| HAVCR2hepatitis A virus cellular receptor 2 | Rarely (1–4%) | In 1 condition |
| LEMD3LEM domain containing 3 | Rarely (1–4%) | In 1 condition |
| MTHFD1methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 | Rarely (1–4%) | In 1 condition |
| PI4KAphosphatidylinositol 4-kinase alpha | Rarely (1–4%) | In 1 condition |
| SMARCAL1SNF2 related chromatin remodeling annealing helicase 1 | Rarely (1–4%) | In 1 condition |
| STOX1storkhead box 1 | Rarely (1–4%) | In 1 condition |
| ABCB11ATP binding cassette subfamily B member 11 | Not recorded | In 1 condition |
| ABCB4ATP binding cassette subfamily B member 4 | Not recorded | In 1 condition |
| AKT2AKT serine/threonine kinase 2 | Not recorded | In 1 condition |
| ATP8B1ATPase phospholipid transporting 8B1 | Not recorded | In 1 condition |
| C1GALT1C1C1GALT1 specific chaperone 1 | Not recorded | In 1 condition |
| C1QAcomplement C1q A chain | Not recorded | In 1 condition |
| C1Rcomplement C1r | Not recorded | In 1 condition |
| CD19CD19 molecule | Not recorded | In 1 condition |
| CR2complement C3d receptor 2 | Not recorded | In 1 condition |
| HNF1AHNF1 homeobox A | Not recorded | In 1 condition |
| ICOSinducible T cell costimulator | Not recorded | In 1 condition |
| ITKIL2 inducible T cell kinase | Not recorded | In 1 condition |
| MC2Rmelanocortin 2 receptor | Not recorded | In 1 condition |
| MRAPmelanocortin 2 receptor accessory protein | Not recorded | In 1 condition |
| NNTnicotinamide nucleotide transhydrogenase | Not recorded | In 1 condition |
| NR1H4nuclear receptor subfamily 1 group H member 4 | Not recorded | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Not recorded | In 1 condition |
| PAX4paired box 4 | Not recorded | In 1 condition |
| PRG4proteoglycan 4 | Not recorded | In 1 condition |
| PRKCDprotein kinase C delta | Not recorded | In 1 condition |
| SERPING1serpin family G member 1 | Not recorded | In 1 condition |
| STARsteroidogenic acute regulatory protein | Not recorded | In 1 condition |
| STAT3signal transducer and activator of transcription 3 | Not recorded | In 1 condition |
| TNFRSF13BTNF receptor superfamily member 13B | Not recorded | In 2 conditions |
| TNFRSF13CTNF receptor superfamily member 13C | Not recorded | In 1 condition |
| TRAPPC2trafficking protein particle complex subunit 2 | Not recorded | In 1 condition |
| TXNRD2thioredoxin reductase 2 | Not recorded | In 1 condition |
| ZAP70zeta chain of T cell receptor associated protein kinase 70 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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