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Trait

Increased double-negative T cell number

Abnormal increase of double negative (DN) CD3+CD4-CD8- T cells, measured as percentage of total CD3+ T cells in the blood, compared to a reference range for a given sex and age-group. These are usually measured within the TCR alpha/beta positive population.

HPO HP:0002851

Summary

Also called
Elevated double-negative T cell proportion, Elevated proportion of CD4-negative, CD8-negative T cells, Increased number of CD4-/CD8- T cells expressing alpha/beta T-cell receptors
Body system
Abnormality of blood and blood-forming tissuesAbnormality of the immune system

5 genes linked to Increased double-negative T cell number

Changes in these genes cause rare conditions in which Increased double-negative T cell number is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
CASP10caspase 10AlwaysIn 2 conditions
PIK3CGphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaAlwaysIn 1 condition
WASWASP actin nucleation promoting factorAlwaysIn 1 condition
FASFas cell surface death receptorOften (30–79%)In 2 conditions
FASLGFas ligandOften (30–79%)In 2 conditions

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal double-negative T cell proportion

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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