Trait
Increased tears
Clinical name: Epiphora
Abnormally increased lacrimation, that is, excessive tearing (watering eye).
Summary
- Also called
- Tearing, Watery eyes, Increased lacrimation
- Body system
- Abnormality of the eye
Reference genomeGRCh38hg38
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Get my Genome Test33 genes linked to Increased tears
Changes in these genes cause rare conditions in which Increased tears is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| IGSF3immunoglobulin superfamily member 3 | Always | In 1 condition |
| CYP1B1cytochrome P450 family 1 subfamily B member 1 | Often (30–79%) | In 1 condition |
| FGF10fibroblast growth factor 10 | Often (30–79%) | In 1 condition |
| FGFR2fibroblast growth factor receptor 2 | Often (30–79%) | In 1 condition |
| FGFR3fibroblast growth factor receptor 3 | Often (30–79%) | In 1 condition |
| LTBP2latent transforming growth factor beta binding protein 2 | Often (30–79%) | In 1 condition |
| MYOCmyocilin | Often (30–79%) | In 1 condition |
| PRNPprion protein (Kanno blood group) | Often (30–79%) | In 1 condition |
| TACSTD2tumor associated calcium signal transducer 2 | Often (30–79%) | In 1 condition |
| TEKTEK receptor tyrosine kinase | Often (30–79%) | In 1 condition |
| TINF2TERF1 interacting nuclear factor 2 | Often (30–79%) | In 1 condition |
| ATOH7atonal bHLH transcription factor 7 | Sometimes (5–29%) | In 1 condition |
| COL17A1collagen type XVII alpha 1 chain | Sometimes (5–29%) | In 2 conditions |
| FASFas cell surface death receptor | Sometimes (5–29%) | In 1 condition |
| FZD4frizzled class receptor 4 | Sometimes (5–29%) | In 1 condition |
| GNAQG protein subunit alpha q | Sometimes (5–29%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Sometimes (5–29%) | In 2 conditions |
| NDPnorrin cystine knot growth factor NDP | Sometimes (5–29%) | In 1 condition |
| PARNpoly(A)-specific ribonuclease | Sometimes (5–29%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Sometimes (5–29%) | In 1 condition |
| SDHDsuccinate dehydrogenase complex subunit D | Sometimes (5–29%) | In 1 condition |
| TYMSthymidylate synthetase | Sometimes (5–29%) | In 1 condition |
| SLC39A14solute carrier family 39 member 14 | Rarely (1–4%) | In 1 condition |
| DKC1dyskerin pseudouridine synthase 1 | Not recorded | In 1 condition |
| KRT12keratin 12 | Not recorded | In 1 condition |
| KRT3keratin 3 | Not recorded | In 1 condition |
| LRP1LDL receptor related protein 1 | Not recorded | In 1 condition |
| NHP2NHP2 ribonucleoprotein | Not recorded | In 1 condition |
| NLRP3NLR family pyrin domain containing 3 | Not recorded | In 1 condition |
| NOP10NOP10 ribonucleoprotein | Not recorded | In 1 condition |
| OVOL2ovo like zinc finger 2 | Not recorded | In 1 condition |
| SEMA4Asemaphorin 4A | Not recorded | In 1 condition |
| SREBF1sterol regulatory element binding transcription factor 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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