Trait
Increased circulating IgA concentration
An abnormally increased level of immunoglobulin A in blood.
Summary
- Also called
- Elevated IgA, Elevated serum IgA, IgA hypergammaglobulinemia, Increased circulating IgA level, Increased levels of IgA, Increased serum IgA
Reference genomeGRCh38hg38
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Get my Genome Test37 genes linked to Increased circulating IgA concentration
Changes in these genes cause rare conditions in which Increased circulating IgA concentration is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ARPC5actin related protein 2/3 complex subunit 5 | Always | In 1 condition |
| CD247CD247 molecule | Always | In 1 condition |
| DMRT2doublesex and mab-3 related transcription factor 2 | Always | In 1 condition |
| FLT3LGfms related receptor tyrosine kinase 3 ligand | Always | In 1 condition |
| GTF2H5general transcription factor IIH subunit 5 | Always | In 1 condition |
| ITPR3inositol 1,4,5-trisphosphate receptor type 3 | Always | In 1 condition |
| OTULINOTU deubiquitinase with linear linkage specificity | Always | In 1 condition |
| PDCD1programmed cell death 1 | Always | In 1 condition |
| POMPproteasome maturation protein | Always | In 1 condition |
| PSMB8proteasome 20S subunit beta 8 | Always | In 1 condition |
| RASGRP1RAS guanyl releasing protein 1 | Always | In 1 condition |
| SEC61A1SEC61 translocon subunit alpha 1 | Always | In 1 condition |
| STING1stimulator of interferon response cGAMP interactor 1 | Always | In 1 condition |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Very often (80–99%) | In 2 conditions |
| MVKmevalonate kinase | Very often (80–99%) | In 2 conditions |
| CARD10caspase recruitment domain family member 10 | Often (30–79%) | In 1 condition |
| COPZ1coat protein complex I subunit zeta 1 | Often (30–79%) | In 1 condition |
| IRF1interferon regulatory factor 1 | Often (30–79%) | In 1 condition |
| NLRP1NLR family pyrin domain containing 1 | Often (30–79%) | In 1 condition |
| STIM1stromal interaction molecule 1 | Often (30–79%) | In 1 condition |
| CASP10caspase 10 | Sometimes (5–29%) | In 2 conditions |
| CCND1cyclin D1 | Sometimes (5–29%) | In 1 condition |
| CD40LGCD40 ligand | Sometimes (5–29%) | In 1 condition |
| FASFas cell surface death receptor | Sometimes (5–29%) | In 2 conditions |
| FASLGFas ligand | Sometimes (5–29%) | In 2 conditions |
| IL12Ainterleukin 12A | Sometimes (5–29%) | In 1 condition |
| IL12RB1interleukin 12 receptor subunit beta 1 | Sometimes (5–29%) | In 1 condition |
| IL7Rinterleukin 7 receptor | Sometimes (5–29%) | In 1 condition |
| IRF5interferon regulatory factor 5 | Sometimes (5–29%) | In 1 condition |
| MMEL1membrane metalloendopeptidase like 1 | Sometimes (5–29%) | In 1 condition |
| PGM3phosphoglucomutase 3 | Sometimes (5–29%) | In 1 condition |
| POU2AF1POU class 2 homeobox associating factor 1 | Sometimes (5–29%) | In 1 condition |
| SPIBSpi-B transcription factor | Sometimes (5–29%) | In 1 condition |
| TNFSF15TNF superfamily member 15 | Sometimes (5–29%) | In 1 condition |
| TNPO3transportin 3 | Sometimes (5–29%) | In 1 condition |
| TRAF3TNF receptor associated factor 3 | Sometimes (5–29%) | In 1 condition |
| WASWASP actin nucleation promoting factor | Not recorded | In 2 conditions |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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