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Trait

High lymphocyte count

Clinical name: Increased total lymphocyte count

Increase in the number or proportion of lymphocytes in the blood.

HPO HP:0100827

Summary

Also called
Lymphocytosis
Body system
Abnormality of blood and blood-forming tissuesAbnormality of the immune system

19 genes linked to High lymphocyte count

Changes in these genes cause rare conditions in which High lymphocyte count is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
PTCRApre T cell antigen receptor alphaAlwaysIn 1 condition
RELREL proto-oncogene, NF-kB subunitAlwaysIn 1 condition
DCLRE1CDNA cross-link repair 1COften (30–79%)In 1 condition
ELF4E74 like ETS transcription factor 4Often (30–79%)In 1 condition
LMNB2lamin B2Often (30–79%)In 1 condition
RAG1recombination activating 1Often (30–79%)In 1 condition
RAG2recombination activating 2Often (30–79%)In 1 condition
CASP10caspase 10Sometimes (5–29%)In 1 condition
EIF2AK3eukaryotic translation initiation factor 2 alpha kinase 3Sometimes (5–29%)In 1 condition
FASFas cell surface death receptorSometimes (5–29%)In 1 condition
FASLGFas ligandSometimes (5–29%)In 1 condition
FOCADfocadhesinSometimes (5–29%)In 1 condition
IL7Rinterleukin 7 receptorSometimes (5–29%)In 1 condition
ZAP70zeta chain of T cell receptor associated protein kinase 70Sometimes (5–29%)In 1 condition
ARPC1Bactin related protein 2/3 complex subunit 1BNot recordedIn 1 condition
NRASNRAS proto-oncogene, GTPaseNot recordedIn 1 condition
RNASEH2Bribonuclease H2 subunit BNot recordedIn 1 condition
SH2D1ASH2 domain containing 1ANot recordedIn 1 condition
XIAPX-linked inhibitor of apoptosisNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal lymphocyte count

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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